;PMID: 1902567 ;source_file_2862.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..51] = [t:0..51] ;1)sentence:[e:57..124] = [t:57..124] ;2)section:[e:128..180] = [t:128..180] ;3)section:[e:184..255] = [t:184..255] ;4)sentence:[e:259..426] = [t:259..426] ;5)sentence:[e:427..562] = [t:427..562] ;6)sentence:[e:563..702] = [t:563..702] ;7)sentence:[e:703..764] = [t:703..764] ;8)sentence:[e:765..932] = [t:765..932] ;9)sentence:[e:933..1096] = [t:933..1096] ;10)sentence:[e:1097..1324] = [t:1097..1324] ;11)section:[e:1328..1372] = [t:1328..1372] ;section 0 Span:0..51 ;Proc Natl Acad Sci U S A. 1991 May 1;88(9):3554-8. (SEC (FRAG (NNP:[0..4] Proc) (NNP:[5..9] Natl) (NNP:[10..14] Acad) (NNP:[15..18] Sci) (NNP:[19..20] U) (NNP:[21..22] S) (NNP:[23..24] A) (IN:[24..25] .) (CD:[27..31] 1991) (NNP:[32..35] May) (CD:[36..40] 1;88) (-LRB-:[40..41] -LRB-) (CD:[41..42] 9) (-RRB-:[42..43] -RRB-) (::[43..44] :) (CD:[44..48] 3554) (::[48..49] -) (CD:[49..51] 8.))) ;sentence 1 Span:57..124 ;Neurotrophic protein S100 beta stimulates glial cell proliferation. ;[78..87]:gene-protein:"S100 beta" (SENT (S (NP-SBJ (NML (JJ:[57..69] Neurotrophic) (NN:[70..77] protein)) (NN:[78..82] S100) (SYM:[83..87] beta)) (VP (VBZ:[88..98] stimulates) (NP (NML (JJ:[99..104] glial) (NN:[105..109] cell)) (NN:[110..123] proliferation))) (.:[123..124] .))) ;section 2 Span:128..180 ;Selinfreund RH, Barger SW, Pledger WJ, Van Eldik LJ. (SEC (FRAG (NNP:[128..139] Selinfreund) (NNP:[140..142] RH) (,:[142..143] ,) (NNP:[144..150] Barger) (NNP:[151..153] SW) (,:[153..154] ,) (NNP:[155..162] Pledger) (NNP:[163..165] WJ) (,:[165..166] ,) (NNP:[167..170] Van) (NNP:[171..176] Eldik) (NNP:[177..180] LJ.))) ;section 3 Span:184..255 ;Department of Pharmacology, Vanderbilt University, Nashville, TN 37232. (SEC (FRAG (NNP:[184..194] Department) (IN:[195..197] of) (NNP:[198..210] Pharmacology) (,:[210..211] ,) (NNP:[212..222] Vanderbilt) (NNP:[223..233] University) (,:[233..234] ,) (NNP:[235..244] Nashville) (,:[244..245] ,) (NN:[246..248] TN) (CD:[249..254] 37232) (.:[254..255] .))) ;sentence 4 Span:259..426 ;Nervous system development involves a coordinated series of events, including ; regulation of cell proliferation and differentiation by specific ;extracellular factors. (SENT (S (NP-SBJ (NML (JJ:[259..266] Nervous) (NN:[267..273] system)) (NN:[274..285] development)) (VP (VBZ:[286..294] involves) (NP (NP (DT:[295..296] a) (VBN:[297..308] coordinated) (NN:[309..315] series)) (PP (IN:[316..318] of) (NP (NP (NNS:[319..325] events)) (,:[325..326] ,) (PP (VBG:[327..336] including) (NP (NP (NN:[338..348] regulation)) (PP (IN:[349..351] of) (NP (NP (NML-1 (NN:[352..356] cell)) (NN:[357..370] proliferation)) (CC:[371..374] and) (NP (NML-1 (-NONE-:[374..374] *P*)) (NN:[375..390] differentiation)))) (PP (IN:[391..393] by) (NP (JJ:[394..402] specific) (JJ:[403..416] extracellular) (NNS:[418..425] factors))))))))) (.:[425..426] .))) ;sentence 5 Span:427..562 ;S100 beta is a neurotrophic protein that has been implicated in regulation ;of cellular proliferation, but direct evidence was lacking. ;[427..436]:gene-protein:"S100 beta" (SENT (S (S (NP-SBJ (NN:[427..431] S100) (SYM:[432..436] beta)) (VP (VBZ:[437..439] is) (NP-PRD (NP (DT:[440..441] a) (JJ:[442..454] neurotrophic) (NN:[455..462] protein)) (SBAR (WHNP-1 (WDT:[463..467] that)) (S (NP-SBJ-1 (-NONE-:[467..467] *T*)) (VP (VBZ:[468..471] has) (VP (VBN:[472..476] been) (VP (VBN:[477..487] implicated) (NP-1 (-NONE-:[487..487] *)) (PP (IN:[488..490] in) (NP (NP (NN:[492..502] regulation)) (PP (IN:[503..505] of) (NP (JJ:[506..514] cellular) (NN:[515..528] proliferation))))))))))))) (,:[528..529] ,) (CC:[530..533] but) (S (NP-SBJ (JJ:[534..540] direct) (NN:[541..549] evidence)) (VP (VBD:[550..553] was) (ADJP-PRD (VBG:[554..561] lacking)))) (.:[561..562] .))) ;sentence 6 Span:563..702 ;In this report, nanomolar concentrations of S100 beta are shown to stimulate ; proliferation of rat C6 glioma cells and primary astrocytes. ;[608..617]:gene-protein:"S100 beta" ;[666..678]:malignancy-type:"glioma cells" (SENT (S (PP (IN:[563..565] In) (NP (DT:[566..570] this) (NN:[572..578] report))) (,:[578..579] ,) (NP-SBJ-1 (NP (JJ:[580..589] nanomolar) (NNS:[590..604] concentrations)) (PP (IN:[605..607] of) (NP (NN:[608..612] S100) (SYM:[613..617] beta)))) (VP (VBP:[618..621] are) (VP (VBN:[622..627] shown) (S (NP-SBJ-1 (-NONE-:[627..627] *)) (VP (TO:[628..630] to) (VP (VB:[631..640] stimulate) (NP (NP (NN:[642..655] proliferation)) (PP (IN:[656..658] of) (NP (NP (NML-2 (NN:[659..662] rat)) (NN:[663..665] C6) (NN:[666..672] glioma) (NNS:[673..678] cells)) (CC:[679..682] and) (NP (NML-2 (-NONE-:[682..682] *P*)) (JJ:[683..690] primary) (NNS:[691..701] astrocytes)))))))))) (.:[701..702] .))) ;sentence 7 Span:703..764 ;An S100 mutant with a single amino acid change was inactive. ;[706..710]:gene-protein:"S100" ;[726..750]:variation-type:"single amino acid change" (SENT (S (NP-SBJ (NP (DT:[703..705] An) (NN:[706..710] S100) (NN:[711..717] mutant)) (PP (IN:[718..722] with) (NP (DT:[724..725] a) (NP (JJ:[726..732] single) (NML (JJ:[733..738] amino) (NN:[739..743] acid)) (NN:[744..750] change))))) (VP (VBD:[751..754] was) (ADJP-PRD (JJ:[755..763] inactive))) (.:[763..764] .))) ;sentence 8 Span:765..932 ;S100 beta also stimulated increases in the steady-state levels of c-myc and ;c-fos protooncogene mRNAs and complemented the effects of platelet-derived ;growth factor. ;[765..774]:gene-protein:"S100 beta" ;[832..837]:gene-rna:"c-myc" ;[842..847]:gene-rna:"c-fos" ;[901..931]:gene-protein:"platelet-derived growth factor" (SENT (S (NP-SBJ (NN:[765..769] S100) (SYM:[770..774] beta)) (ADVP (RB:[775..779] also)) (VP (VP (VBD:[780..790] stimulated) (NP (NP (NNS:[791..800] increases)) (PP (IN:[801..803] in) (NP (NP (DT:[805..808] the) (NML (JJ:[809..815] steady) (HYPH:[815..816] -) (NN:[816..821] state)) (NNS:[822..828] levels)) (PP (IN:[829..831] of) (NP (NP (NN:[832..837] c-myc) (NML-1 (-NONE-:[837..837] *P*))) (CC:[838..841] and) (NP (NN:[842..847] c-fos) (NML-1 (NN:[848..861] protooncogene) (NNS:[862..867] mRNAs))))))))) (CC:[868..871] and) (VP (VBD:[872..884] complemented) (NP (NP (DT:[886..889] the) (NNS:[890..897] effects)) (PP (IN:[898..900] of) (NP (ADJP (NN:[901..909] platelet) (HYPH:[909..910] -) (VBN:[910..917] derived)) (NN:[918..924] growth) (NN:[925..931] factor)))))) (.:[931..932] .))) ;sentence 9 Span:933..1096 ;Two neuroblastoma cell lines did not proliferate in response to S100 beta, ;suggesting that the mitogenic activity of S100 beta is selective for ;astroglial cells. ;[937..950]:malignancy-type:"neuroblastoma" ;[998..1007]:gene-protein:"S100 beta" ;[1052..1061]:gene-protein:"S100 beta" (SENT (S (NP-SBJ (CD:[933..936] Two) (NN:[937..950] neuroblastoma) (NN:[951..955] cell) (NNS:[956..961] lines)) (VP (VBD:[962..965] did) (RB:[967..970] not) (VP (VB:[971..982] proliferate) (PP (IN:[983..985] in) (NP (NP (NN:[986..994] response)) (PP (TO:[995..997] to) (NP (NN:[998..1002] S100) (SYM:[1003..1007] beta))))) (,:[1007..1008] ,) (S-ADV (NP-SBJ (-NONE-:[1008..1008] *)) (VP (VBG:[1009..1019] suggesting) (SBAR (IN:[1020..1024] that) (S (NP-SBJ (NP (DT:[1025..1028] the) (JJ:[1029..1038] mitogenic) (NN:[1039..1047] activity)) (PP (IN:[1049..1051] of) (NP (NN:[1052..1056] S100) (SYM:[1057..1061] beta)))) (VP (VBZ:[1062..1064] is) (ADJP-PRD (JJ:[1065..1074] selective)) (PP (IN:[1075..1078] for) (NP (JJ:[1079..1089] astroglial) (NNS:[1090..1095] cells)))))))))) (.:[1095..1096] .))) ;sentence 10 Span:1097..1324 ;These results suggest that S100 beta may be involved in the coordinate ;development and maintenance of the central nervous system by synchronously ;stimulating the differentiation of neurons and the proliferation of ;astroglia. ;[1124..1134]:gene-protein:"S100 beta" (SENT (S (NP-SBJ (DT:[1097..1102] These) (NNS:[1103..1110] results)) (VP (VBP:[1111..1118] suggest) (SBAR (IN:[1119..1123] that) (S (NP-SBJ-1 (NN:[1124..1128] S100) (SYM:[1130..1134] beta)) (VP (MD:[1135..1138] may) (VP (VB:[1139..1141] be) (VP (VBN:[1142..1150] involved) (NP-1 (-NONE-:[1150..1150] *)) (PP-CLR (IN:[1151..1153] in) (NP (NP (DT:[1154..1157] the) (JJ:[1158..1168] coordinate) (NN:[1169..1180] development) (CC:[1181..1184] and) (NN:[1185..1196] maintenance)) (PP (IN:[1197..1199] of) (NP (DT:[1200..1203] the) (JJ:[1205..1212] central) (JJ:[1213..1220] nervous) (NN:[1221..1227] system))))) (PP (IN:[1228..1230] by) (S-NOM (NP-SBJ (-NONE-:[1230..1230] *)) (ADVP (RB:[1231..1244] synchronously)) (VP (VBG:[1245..1256] stimulating) (NP (NP (NP (DT:[1257..1260] the) (NN:[1261..1276] differentiation)) (PP (IN:[1277..1279] of) (NP (NNS:[1281..1288] neurons)))) (CC:[1289..1292] and) (NP (NP (DT:[1293..1296] the) (NN:[1297..1310] proliferation)) (PP (IN:[1311..1313] of) (NP (NN:[1314..1323] astroglia)))))))))))))) (.:[1323..1324] .))) ;section 11 Span:1328..1372 ;PMID: 1902567 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1328..1332] PMID) (::[1332..1333] :) (CD:[1334..1341] 1902567) (NN:[1342..1343] -LSB-) (NNP:[1343..1349] PubMed) (::[1350..1351] -) (NN:[1352..1359] indexed) (IN:[1360..1363] for) (NNP:[1364..1372] MEDLINE-RSB-)))