;PMID: 11850193 ;source_file_2847.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..35] = [t:0..35] ;1)sentence:[e:41..173] = [t:41..173] ;2)section:[e:177..228] = [t:177..228] ;3)section:[e:232..338] = [t:232..338] ;4)sentence:[e:342..517] = [t:342..517] ;5)sentence:[e:518..616] = [t:518..616] ;6)sentence:[e:617..795] = [t:617..795] ;7)sentence:[e:796..1014] = [t:796..1014] ;8)sentence:[e:1015..1163] = [t:1015..1163] ;9)sentence:[e:1164..1284] = [t:1164..1284] ;10)section:[e:1288..1333] = [t:1288..1333] ;section 0 Span:0..35 ;Mech Dev. 2002 Mar;112(1-2):191-3. (SEC (FRAG (NNP:[0..4] Mech) (NNP:[5..8] Dev) (.:[8..9] .) ('':[11..15] 2002) (CC:[16..24] Mar;112-LRB-) (CD:[24..27] 1-2) (-RRB-:[27..28] -RRB-) (CD:[28..35] :191-3.))) ;sentence 1 Span:41..173 ;Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in ;differentiating cells in the developing rodent forebrain. ;[41..47]:gene-rna:"Etr-r3" ;[48..54]:gene-rna:"mNapor" ;[68..97]:gene-protein:"ELAV-type RNA binding protein" (SENT (S-HLN (NP-SBJ-1 (NP (NN:[41..47] Etr-r3) (SYM:[47..48] /) (NN:[48..54] mNapor)) (,:[54..55] ,) (VP (VBG:[56..64] encoding) (NP (DT:[65..67] an) (NML (NN:[68..72] ELAV) (HYPH:[72..73] -) (NN:[73..77] type)) (NN:[78..81] RNA) (NN:[82..89] binding) (NN:[90..97] protein)))) (,:[97..98] ,) (VP (VBZ:[99..101] is) (VP (VBN:[102..111] expressed) (NP-1 (-NONE-:[111..111] *)) (PP-LOC (IN:[112..114] in) (NP (VBG:[116..131] differentiating) (NNS:[132..137] cells))) (PP-LOC (IN:[138..140] in) (NP (DT:[141..144] the) (VBG:[145..155] developing) (NN:[156..162] rodent) (NN:[163..172] forebrain))))) (.:[172..173] .))) ;section 2 Span:177..228 ;Levers TE, Tait S, Birling MC, Brophy PJ, Price DJ. (SEC (FRAG (NNP:[177..183] Levers) (NNP:[184..186] TE) (,:[186..187] ,) (NNP:[188..192] Tait) (NNP:[193..194] S) (,:[194..195] ,) (NNP:[196..203] Birling) (NNP:[204..206] MC) (,:[206..207] ,) (NNP:[208..214] Brophy) (NNP:[215..217] PJ) (,:[217..218] ,) (NNP:[219..224] Price) (NNP:[225..228] DJ.))) ;section 3 Span:232..338 ;Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George ;Square, Edinburgh EH8 9XD, UK. (SEC (FRAG (NNP:[232..242] Biomedical) (NNP:[243..251] Sciences) (,:[251..252] ,) (NNP:[253..263] University) (IN:[264..266] of) (NNP:[267..276] Edinburgh) (,:[276..277] ,) (NNP:[278..282] Hugh) (NNP:[283..289] Robson) (NNP:[290..298] Building) (,:[298..299] ,) (NNP:[300..306] George) (NNP:[308..314] Square) (,:[314..315] ,) (NNP:[316..325] Edinburgh) (NNP:[326..329] EH8) (NNP:[330..333] 9XD) (,:[333..334] ,) (NNP:[335..338] UK.))) ;sentence 4 Span:342..517 ;The gene encoding human neuroblastoma apoptosis-related RNA binding protein ;(NAPOR) has rat and mouse homologues, Etr-r3 and mNapor, cloned recently by ;ourselves and others. ;[366..417]:gene-protein:"neuroblastoma apoptosis-related RNA binding ;protein" ;[366..379]:malignancy-type:"neuroblastoma" ;[420..425]:gene-protein:"NAPOR" ;[457..463]:gene-rna:"Etr-r3" ;[468..474]:gene-rna:"mNapor" (SENT (S (NP-SBJ (NP (DT:[342..345] The) (NN:[346..350] gene)) (VP (VBG:[351..359] encoding) (NP (JJ:[360..365] human) (NML (NML (NN:[366..379] neuroblastoma) (ADJP (NN:[380..389] apoptosis) (HYPH:[389..390] -) (VBN:[390..397] related)) (NN:[398..401] RNA) (NN:[402..409] binding) (NN:[410..417] protein)) (NML (-LRB-:[419..420] -LRB-) (NN:[420..425] NAPOR) (-RRB-:[425..426] -RRB-)))))) (VP (VBZ:[427..430] has) (NP (NP (NP (NP (NN:[431..434] rat) (NML-1 (-NONE-:[434..434] *P*))) (CC:[435..438] and) (NP (NN:[439..444] mouse) (NML-1 (NNS:[445..455] homologues)))) (,:[455..456] ,) (NP (NN:[457..463] Etr-r3) (CC:[464..467] and) (NN:[468..474] mNapor))) (,:[474..475] ,) (VP (VBN:[476..482] cloned) (NP (-NONE-:[482..482] *)) (ADVP-TMP (RB:[483..491] recently)) (PP (IN:[492..494] by) (NP-LGS (NP (PRP:[496..505] ourselves)) (CC:[506..509] and) (NP (NNS:[510..516] others))))))) (.:[516..517] .))) ;sentence 5 Span:518..616 ;Etr-r3/mNapor is transcribed in embryonic brain but its detailed expression ;patterns are unknown. ;[518..524]:gene-rna:"Etr-r3" ;[525..531]:gene-rna:"mNapor" (SENT (S (S (NP-SBJ-1 (NN:[518..524] Etr-r3) (SYM:[524..525] /) (NN:[525..531] mNapor)) (VP (VBZ:[532..534] is) (VP (VBN:[535..546] transcribed) (NP-1 (-NONE-:[546..546] *)) (PP-LOC (IN:[547..549] in) (NP (JJ:[550..559] embryonic) (NN:[560..565] brain)))))) (CC:[566..569] but) (S (NP-SBJ (PRP$:[570..573] its) (VBN:[575..583] detailed) (NN:[584..594] expression) (NNS:[595..603] patterns)) (VP (VBP:[604..607] are) (ADJP-PRD (JJ:[608..615] unknown)))) (.:[615..616] .))) ;sentence 6 Span:617..795 ;It has been hypothesised that its expression coincides with the occurrence ;of programmed cell death, but existing expression data are insufficient to ;evaluate this possibility. (SENT (S (S (NP-SBJ-1 (NP (PRP:[617..619] It)) (SBAR-2 (-NONE-:[619..619] *EXP*))) (VP (VBZ:[620..623] has) (VP (VBN:[624..628] been) (VP (VBN:[629..641] hypothesised) (NP-1 (-NONE-:[641..641] *)) (SBAR-2 (IN:[642..646] that) (S (NP-SBJ (PRP$:[647..650] its) (NN:[652..662] expression)) (VP (VBZ:[663..672] coincides) (PP (IN:[673..677] with) (NP (NP (DT:[678..681] the) (NN:[682..692] occurrence)) (PP (IN:[693..695] of) (NP (VBN:[696..706] programmed) (NN:[707..711] cell) (NN:[712..717] death)))))))))))) (,:[717..718] ,) (CC:[719..722] but) (S (NP-SBJ (VBG:[723..731] existing) (NN:[733..743] expression) (NNS:[744..748] data)) (VP (VBP:[749..752] are) (ADJP-PRD (JJ:[753..765] insufficient) (S (NP-SBJ (-NONE-:[765..765] *)) (VP (TO:[766..768] to) (VP (VB:[769..777] evaluate) (NP (DT:[778..782] this) (NN:[783..794] possibility)))))))) (.:[794..795] .))) ;sentence 7 Span:796..1014 ;We used northern blots and in situ hybridisation to show that Etr-r3/mNapor ;is expressed by most postmitotic differentiating cells throughout the ;forebrain during embryogenesis and the first weeks of postnatal life. ;[859..865]:gene-rna:"Etr-r3" ;[866..872]:gene-rna:"mNapor" (SENT (S (NP-SBJ (PRP:[796..798] We)) (VP (VBD:[799..803] used) (NP (NP (JJ:[804..812] northern) (NNS:[814..819] blots)) (CC:[820..823] and) (NP (ADVP (FW:[824..826] in) (FW:[827..831] situ)) (NN:[832..845] hybridisation))) (S-ADV (NP-SBJ (-NONE-:[845..845] *)) (VP (TO:[846..848] to) (VP (VB:[849..853] show) (SBAR (IN:[854..858] that) (S (NP-SBJ-1 (NN:[859..865] Etr-r3) (SYM:[865..866] /) (NN:[866..872] mNapor)) (VP (VBZ:[873..875] is) (VP (VBN:[876..885] expressed) (NP-1 (-NONE-:[885..885] *)) (PP (IN:[886..888] by) (NP-LGS (JJS:[889..893] most) (JJ:[895..906] postmitotic) (VBG:[907..922] differentiating) (NNS:[923..928] cells))) (PP-LOC (IN:[929..939] throughout) (NP (DT:[940..943] the) (NN:[944..953] forebrain))) (PP-TMP (IN:[954..960] during) (NP (NP (NN:[961..974] embryogenesis)) (CC:[976..979] and) (NP (NP (DT:[980..983] the) (JJ:[984..989] first) (NNS:[990..995] weeks)) (PP (IN:[996..998] of) (NP (JJ:[999..1008] postnatal) (NN:[1009..1013] life)))))))))))))) (.:[1013..1014] .))) ;sentence 8 Span:1015..1163 ;Expression is particularly high in the developing cerebral cortex, in nuclei ;of the ventral telencephalon, in dorsal thalamus and in hypothalamus. (SENT (S (NP-SBJ (NN:[1015..1025] Expression)) (VP (VBZ:[1026..1028] is) (ADJP-PRD (RB:[1029..1041] particularly) (JJ:[1042..1046] high)) (PP-LOC (PP (IN:[1047..1049] in) (NP (DT:[1050..1053] the) (VBG:[1055..1065] developing) (JJ:[1066..1074] cerebral) (NN:[1075..1081] cortex))) (,:[1081..1082] ,) (PP (IN:[1083..1085] in) (NP (NP (NNS:[1086..1092] nuclei)) (PP (IN:[1093..1095] of) (NP (DT:[1096..1099] the) (JJ:[1100..1107] ventral) (NN:[1108..1121] telencephalon))))) (,:[1121..1122] ,) (PP (IN:[1123..1125] in) (NP (JJ:[1126..1132] dorsal) (NN:[1134..1142] thalamus))) (CC:[1143..1146] and) (PP (IN:[1147..1149] in) (NP (NN:[1150..1162] hypothalamus))))) (.:[1162..1163] .))) ;sentence 9 Span:1164..1284 ;In contrast, Etr-r3/mNapor is expressed by very few cells in proliferative ;regions, where cell death rates are highest. ;[1177..1183]:gene-rna:"Etr-r3" ;[1184..1190]:gene-rna:"mNapor" (SENT (S (PP (IN:[1164..1166] In) (NP (NN:[1167..1175] contrast))) (,:[1175..1176] ,) (NP-SBJ-2 (NN:[1177..1183] Etr-r3) (SYM:[1183..1184] /) (NN:[1184..1190] mNapor)) (VP (VBZ:[1191..1193] is) (VP (VBN:[1194..1203] expressed) (NP-2 (-NONE-:[1203..1203] *)) (PP (IN:[1204..1206] by) (NP-LGS (RB:[1207..1211] very) (JJ:[1213..1216] few) (NNS:[1217..1222] cells))) (PP-LOC (IN:[1223..1225] in) (NP (NP (JJ:[1226..1239] proliferative) (NNS:[1240..1247] regions)) (,:[1247..1248] ,) (SBAR (WHADVP-1 (WRB:[1249..1254] where)) (S (NP-SBJ (NN:[1255..1259] cell) (NN:[1260..1265] death) (NNS:[1266..1271] rates)) (VP (VBP:[1272..1275] are) (ADJP-PRD (JJS:[1276..1283] highest)) (ADVP-1 (-NONE-:[1283..1283] *T*))))))))) (.:[1283..1284] .))) ;section 10 Span:1288..1333 ;PMID: 11850193 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1288..1292] PMID) (::[1292..1293] :) (CD:[1294..1302] 11850193) (NN:[1303..1304] -LSB-) (NNP:[1304..1310] PubMed) (::[1311..1312] -) (NN:[1313..1320] indexed) (IN:[1321..1324] for) (NNP:[1325..1333] MEDLINE-RSB-)))