;PMID: 6587382 ;source_file_1236.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..48] = [t:0..48] ;1)sentence:[e:53..137] = [t:53..137] ;2)section:[e:141..210] = [t:141..210] ;3)sentence:[e:214..332] = [t:214..332] ;4)sentence:[e:333..500] = [t:333..500] ;5)sentence:[e:501..604] = [t:501..604] ;6)sentence:[e:605..817] = [t:605..817] ;7)section:[e:821..865] = [t:821..865] ;section 0 Span:0..48 ;Proc Natl Acad Sci U S A 1984 Jun;81(12):3670-4 (SEC (FRAG (NNP:[0..4] Proc) (NNP:[5..9] Natl) (NNP:[10..14] Acad) (NNP:[15..18] Sci) (NNP:[19..20] U) (NNP:[21..22] S) (NNP:[23..24] A) (CD:[26..30] 1984) (::[31..38] Jun;81-LRB-) (CD:[38..40] 12) (-RRB-:[40..41] -RRB-) (CD:[41..46] :3670) (::[46..47] -) (CD:[47..48] 4))) ;sentence 1 Span:53..137 ;Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma ;cells. ;[83..88]:gene-rna:"N-ras" ;[101..136]:malignancy:"SW-1271 human lung carcinoma cells" (SENT (NP-HLN (NP (NN:[53..62] Mechanism)) (PP (IN:[63..65] of) (NP (NP (NN:[66..76] activation)) (PP (IN:[77..79] of) (NP (NP (DT:[80..82] an) (NN:[83..88] N-ras) (NN:[89..97] oncogene)) (PP (IN:[98..100] of) (NP (NN:[101..108] SW-1271) (JJ:[109..114] human) (NN:[115..119] lung) (NN:[120..129] carcinoma) (NNS:[131..136] cells))))))) (.:[136..137] .))) ;section 2 Span:141..210 ;Yuasa Y, Gol RA, Chang A, Chiu IM, Reddy EP, Tronick SR, Aaronson SA. (SEC (FRAG (NNP:[141..146] Yuasa) (NNP:[147..148] Y) (,:[148..149] ,) (NNP:[150..153] Gol) (NNP:[154..156] RA) (,:[156..157] ,) (NNP:[158..163] Chang) (NNP:[164..165] A) (,:[165..166] ,) (NNP:[167..171] Chiu) (NNP:[172..174] IM) (,:[174..175] ,) (NNP:[176..181] Reddy) (NNP:[182..184] EP) (,:[184..185] ,) (NNP:[186..193] Tronick) (NNP:[194..196] SR) (,:[196..197] ,) (NNP:[198..206] Aaronson) (NNP:[207..209] SA) (.:[209..210] .))) ;sentence 3 Span:214..332 ;An N-ras-related transforming gene was detected in the human lung carcinoma ;cell line SW-1271 and molecularly cloned. ;[217..222]:gene-rna:"N-ras" ;[275..308]:malignancy:"lung carcinoma cell line SW-1271" (SENT (S (NP-SBJ-1 (DT:[214..216] An) (ADJP (NN:[217..222] N-ras) (HYPH:[222..223] -) (VBN:[223..230] related)) (VBG:[231..243] transforming) (NN:[244..248] gene)) (VP (VBD:[249..252] was) (VP (VP (VBN:[253..261] detected) (NP-1 (-NONE-:[261..261] *)) (PP (IN:[262..264] in) (NP (NP (DT:[265..268] the) (JJ:[269..274] human) (NN:[275..279] lung) (NN:[280..289] carcinoma) (NN:[290..294] cell) (NN:[296..300] line)) (NP (NN:[301..308] SW-1271))))) (CC:[309..312] and) (VP (ADVP (RB:[313..324] molecularly)) (VBN:[325..331] cloned) (NP-1 (-NONE-:[331..331] *))))) (.:[331..332] .))) ;sentence 4 Span:333..500 ;The lesion responsible for its acquisition of transforming activity was ;localized to a single nucleotide transition from A to G in codon 61 of the ;predicted protein. ;[439..449]:variation-type:"transition" ;[455..456]:variation-state-original:"A" ;[461..462]:variation-state-altered:"G" ;[466..474]:variation-location:"codon 61" (SENT (S (NP-SBJ-1 (NP (DT:[333..336] The) (NN:[337..343] lesion)) (ADJP (JJ:[344..355] responsible) (PP (IN:[356..359] for) (NP (NP (PRP$:[360..363] its) (NN:[364..375] acquisition)) (PP (IN:[377..379] of) (NP (VBG:[380..392] transforming) (NN:[393..401] activity))))))) (VP (VBD:[402..405] was) (VP (VBN:[406..415] localized) (NP-1 (-NONE-:[415..415] *)) (PP (TO:[416..418] to) (NP (NP (DT:[419..420] a) (JJ:[421..427] single) (NN:[428..438] nucleotide) (NN:[439..449] transition)) (PP (IN:[450..454] from) (NP (NN:[455..456] A))) (PP (TO:[458..460] to) (NP (NN:[461..462] G))))) (PP-LOC (IN:[463..465] in) (NP (NP (NN:[466..471] codon) (CD:[472..474] 61)) (PP (IN:[475..477] of) (NP (DT:[478..481] the) (VBN:[482..491] predicted) (NN:[492..499] protein))))))) (.:[499..500] .))) ;sentence 5 Span:501..604 ;This lesion in the second exon results in the substitution of arginine for ;glutamine at this position. ;[520..531]:variation-location:"second exon" ;[548..560]:variation-type:"substitution" ;[564..572]:variation-state-altered:"arginine" ;[577..586]:variation-state-original:"glutamine" (SENT (S (NP-SBJ (NP (DT:[501..505] This) (NN:[506..512] lesion)) (PP (IN:[513..515] in) (NP (DT:[516..519] the) (JJ:[520..526] second) (NN:[527..531] exon)))) (VP (VBZ:[533..540] results) (PP (IN:[541..543] in) (NP (NP (DT:[544..547] the) (NN:[548..560] substitution)) (PP (IN:[561..563] of) (NP (NN:[564..572] arginine))) (PP (IN:[573..576] for) (NP (NN:[577..586] glutamine))))) (PP-LOC (IN:[587..589] at) (NP (DT:[590..594] this) (NN:[595..603] position)))) (.:[603..604] .))) ;sentence 6 Span:605..817 ;These findings, together with previous studies, indicate that the activation ;of ras oncogenes in human tumors is most commonly due to point mutations at ;one of two major "hot spots" in the ras coding sequence. ;[686..689]:gene-rna:"ras" ;[741..756]:variation-type:"point mutations" ;[797..800]:gene-rna:"ras" (SENT (S (NP-SBJ (DT:[605..610] These) (NNS:[612..620] findings)) (,:[620..621] ,) (ADVP (RB:[622..630] together) (PP (IN:[631..635] with) (NP (JJ:[636..644] previous) (NNS:[645..652] studies)))) (,:[652..653] ,) (VP (VBP:[654..662] indicate) (SBAR (IN:[663..667] that) (S (NP-SBJ (NP (DT:[668..671] the) (NN:[672..682] activation)) (PP (IN:[683..685] of) (NP (NN:[686..689] ras) (NNS:[691..700] oncogenes))) (PP-LOC (IN:[701..703] in) (NP (JJ:[704..709] human) (NNS:[710..716] tumors)))) (VP (VBZ:[717..719] is) (ADVP (RBS:[720..724] most) (RB:[725..733] commonly)) (PP-PRD (JJ:[734..737] due) (PP (TO:[738..740] to) (NP (NP (NN:[741..746] point) (NNS:[747..756] mutations)) (PP (IN:[757..759] at) (NP (NP (CD:[760..763] one)) (PP (IN:[764..766] of) (NP (NP (CD:[767..770] two) (JJ:[772..777] major) (``:[778..779] ") (JJ:[779..782] hot) (NNS:[783..788] spots) ('':[788..789] ")) (PP (IN:[790..792] in) (NP (DT:[793..796] the) (NN:[797..800] ras) (NN:[801..807] coding) (NN:[808..816] sequence)))))))))))))) (.:[816..817] .))) ;section 7 Span:821..865 ;PMID: 6587382 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[821..825] PMID) (::[825..826] :) (CD:[827..834] 6587382) (NN:[835..836] -LSB-) (NNP:[836..842] PubMed) (::[843..844] -) (NN:[845..852] indexed) (IN:[853..856] for) (NNP:[857..865] MEDLINE-RSB-)))