;PMID: 9009246 ;source_file_1226.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..38] = [t:0..38] ;1)sentence:[e:43..150] = [t:43..150] ;2)section:[e:154..191] = [t:154..191] ;3)section:[e:195..295] = [t:195..295] ;4)sentence:[e:299..563] = [t:299..563] ;5)sentence:[e:564..644] = [t:564..644] ;6)sentence:[e:645..724] = [t:645..724] ;7)sentence:[e:725..803] = [t:725..803] ;8)section:[e:807..851] = [t:807..851] ;section 0 Span:0..38 ;Leuk Res 1996 Nov-Dec;20(11-12):901-3 (SEC (FRAG (VBG:[0..4] Leuk) (RB:[5..8] Res) (CD:[10..14] 1996) (IN:[15..19] Nov-) (CD:[19..26] Dec;20-LRB-) (CD:[26..28] 11) (::[28..29] -) (CD:[29..31] 12) (-RRB-:[31..32] -RRB-) (CD:[32..36] :901) (::[36..37] -) (CD:[37..38] 3))) ;sentence 1 Span:43..150 ;RAS gene mutations in Chinese leukaemia patients and members of a family with ; high incidence of leukaemia. ;[43..46]:gene-rna:"RAS" ;[73..82]:malignancy:"leukaemia" ;[140..149]:malignancy:"leukaemia" (SENT (NP-HLN (NP (NN:[43..46] RAS) (NN:[47..51] gene) (NNS:[52..61] mutations)) (PP-LOC (IN:[62..64] in) (NP (NP (JJ:[65..72] Chinese) (NN:[73..82] leukaemia) (NNS:[83..91] patients)) (CC:[92..95] and) (NP (NP (NNS:[96..103] members)) (PP (IN:[104..106] of) (NP (NP (DT:[107..108] a) (NN:[109..115] family)) (PP (IN:[116..120] with) (NP (NP (JJ:[122..126] high) (NN:[127..136] incidence)) (PP (IN:[137..139] of) (NP (NN:[140..149] leukaemia)))))))))) (.:[149..150] .))) ;section 2 Span:154..191 ;He LZ, Stephenson J, He GY, Mufti GJ. (SEC (FRAG (NNP:[154..156] He) (NNP:[157..159] LZ) (,:[159..160] ,) (NNP:[161..171] Stephenson) (NNP:[172..174] J,) (NNP:[175..177] He) (NNP:[178..180] GY) (,:[180..181] ,) (NNP:[182..187] Mufti) (NNP:[188..191] GJ.))) ;section 3 Span:195..295 ;Department of Haematological Medicine, King's College School of Medicine and ;Dentistry, London, UK. (SEC (FRAG (NNP:[195..205] Department) (IN:[206..208] of) (NNP:[209..223] Haematological) (NNP:[224..232] Medicine) (,:[232..233] ,) (NNP:[234..238] King) (POS:[238..240] 's) (NNP:[241..248] College) (NNP:[249..255] School) (IN:[256..258] of) (NNP:[259..267] Medicine) (CC:[268..271] and) (NNP:[273..282] Dentistry) (,:[282..283] ,) (NNP:[284..290] London) (,:[290..291] ,) (NNP:[292..295] UK.))) ;sentence 4 Span:299..563 ;We investigated mutations of N-RAS and K-RAS by using polymerase chain ;reaction (PCR)-oligonucleotide hybridization techniques in 40 cases of ;Chinese leukaemia patients and 17 presently healthy members of a family with ;high incidence of acute myeloid leukaemia. ;[328..333]:gene-rna:"N-RAS" ;[338..343]:gene-rna:"K-RAS" ;[353..363]:gene-protein:"polymerase" ;[450..459]:malignancy:"leukaemia" ;[539..562]:malignancy:"acute myeloid leukaemia" (SENT (S (NP-SBJ (PRP:[299..301] We)) (VP (VBD:[302..314] investigated) (NP (NP (NNS:[315..324] mutations)) (PP (IN:[325..327] of) (NP (NP (NN:[328..333] N-RAS)) (CC:[334..337] and) (NP (NN:[338..343] K-RAS))))) (PP-MNR (IN:[344..346] by) (S (NP-SBJ (-NONE-:[346..346] *)) (VP (VBG:[347..352] using) (NP (NML (NML (NML (NN:[353..363] polymerase) (NN:[364..369] chain) (NN:[370..378] reaction)) (NML (-LRB-:[380..381] -LRB-) (NN:[381..384] PCR) (-RRB-:[384..385] -RRB-))) (HYPH:[385..386] -) (NML (NN:[386..401] oligonucleotide) (NN:[402..415] hybridization))) (NNS:[416..426] techniques)) (PP (IN:[427..429] in) (NP (NP (CD:[430..432] 40) (NNS:[433..438] cases)) (PP (IN:[439..441] of) (NP (NP (JJ:[442..449] Chinese) (NN:[450..459] leukaemia) (NNS:[461..469] patients)) (CC:[470..473] and) (NP (NP (CD:[474..476] 17) (ADJP (RB:[477..486] presently) (JJ:[487..494] healthy)) (NNS:[495..502] members)) (PP (IN:[503..505] of) (NP (NP (DT:[506..507] a) (NN:[508..514] family)) (PP (IN:[515..519] with) (NP (NP (JJ:[520..524] high) (NN:[525..534] incidence)) (PP (IN:[535..537] of) (NP (JJ:[539..544] acute) (JJ:[545..552] myeloid) (NN:[553..562] leukaemia)))))))))))))))) (.:[562..563] .))) ;sentence 5 Span:564..644 ;The results showed only two patients carried the mutation in codon 12 of ;N-RAS. ;[614..622]:variation-event:"mutation" ;[626..634]:variation-location:"codon 12" ;[638..643]:gene-rna:"N-RAS" (SENT (S (NP-SBJ (DT:[564..567] The) (NNS:[568..575] results)) (VP (VBD:[576..582] showed) (SBAR (-NONE-:[582..582] 0) (S (NP-SBJ (ADVP (RB:[583..587] only)) (CD:[588..591] two) (NNS:[592..600] patients)) (VP (VBD:[601..608] carried) (NP (NP (DT:[609..612] the) (NN:[614..622] mutation)) (PP-LOC (IN:[623..625] in) (NP (NP (NN:[626..631] codon) (CD:[632..634] 12)) (PP (IN:[635..637] of) (NP (NN:[638..643] N-RAS)))))))))) (.:[643..644] .))) ;sentence 6 Span:645..724 ;Strikingly, however, in both cases the malignancies involved lymphoid ;lineage. ;[685..697]:malignancy:"malignancies" (SENT (S (ADVP (RB:[645..655] Strikingly)) (,:[655..656] ,) (ADVP (RB:[657..664] however)) (,:[664..665] ,) (PP (IN:[666..668] in) (NP (DT:[669..673] both) (NNS:[674..679] cases))) (NP-SBJ (DT:[680..683] the) (NNS:[685..697] malignancies)) (VP (VBD:[698..706] involved) (NP (JJ:[707..715] lymphoid) (NN:[716..723] lineage))) (.:[723..724] .))) ;sentence 7 Span:725..803 ;There was no hereditary RAS mutation in the members of the remarkable ;family. ;[749..752]:gene-rna:"RAS" (SENT (S (NP-SBJ (EX:[725..730] There)) (VP (VBD:[731..734] was) (NP-PRD (DT:[735..737] no) (JJ:[738..748] hereditary) (NN:[749..752] RAS) (NN:[753..761] mutation)) (PP (IN:[762..764] in) (NP (NP (DT:[766..769] the) (NNS:[770..777] members)) (PP (IN:[778..780] of) (NP (DT:[781..784] the) (JJ:[785..795] remarkable) (NN:[796..802] family)))))) (.:[802..803] .))) ;section 8 Span:807..851 ;PMID: 9009246 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[807..811] PMID) (::[811..812] :) (CD:[813..820] 9009246) (NN:[821..822] -LSB-) (NNP:[822..828] PubMed) (::[829..830] -) (NN:[831..838] indexed) (IN:[839..842] for) (NNP:[843..851] MEDLINE-RSB-)))