;PMID: 11215737 ;source_file_1204.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..36] = [t:0..36] ;1)sentence:[e:41..153] = [t:41..153] ;2)section:[e:157..262] = [t:157..262] ;3)section:[e:266..352] = [t:266..352] ;4)sentence:[e:356..541] = [t:356..541] ;5)sentence:[e:542..796] = [t:542..796] ;6)sentence:[e:797..899] = [t:797..899] ;7)sentence:[e:900..992] = [t:900..992] ;8)sentence:[e:994..1103] = [t:994..1103] ;9)sentence:[e:1104..1198] = [t:1104..1198] ;10)sentence:[e:1199..1361] = [t:1199..1361] ;11)section:[e:1365..1410] = [t:1365..1410] ;section 0 Span:0..36 ;Dig Dis Sci 2000 Nov;45(11):2187-94 (SEC (FRAG (NNP:[0..3] Dig) (NNP:[4..7] Dis) (NNP:[8..11] Sci) (CD:[13..17] 2000) (.:[18..25] Nov;45-LRB-) (CD:[25..27] 11) (-RRB-:[27..28] -RRB-) (CD:[28..33] :2187) (::[33..34] -) (CD:[34..36] 94))) ;sentence 1 Span:41..153 ;No major difference in K-ras and p53 abnormalities in sporadic and hereditary ; nonpolyposis colorectal adenomas. ;[64..69]:gene-rna:"K-ras" ;[74..77]:gene-rna:"p53" ;[95..103]...[120..152]:malignancy:"sporadic"..."nonpolyposis colorectal ;adenomas" ;[108..152]:malignancy:"hereditary nonpolyposis colorectal adenomas" (SENT (NP-HLN (NP (DT:[41..43] No) (JJ:[44..49] major) (NN:[50..60] difference)) (PP (IN:[61..63] in) (NP (NP (NN:[64..69] K-ras) (NML-1 (-NONE-:[69..69] *P*))) (CC:[70..73] and) (NP (NN:[74..77] p53) (NML-1 (NNS:[78..91] abnormalities))))) (PP-LOC (IN:[92..94] in) (NP (ADJP (JJ:[95..103] sporadic) (CC:[104..107] and) (JJ:[108..118] hereditary)) (NN:[120..132] nonpolyposis) (JJ:[133..143] colorectal) (NNS:[144..152] adenomas))) (.:[152..153] .))) ;section 2 Span:157..262 ;Voskuil DW, Kampman E, van Geloof W, Grubben M, Kok F, van Muijen G, ;Nagengast F, Vasen H, van't Veer P. (SEC (FRAG (NNP:[157..164] Voskuil) (NNP:[165..167] DW) (,:[167..168] ,) (NNP:[169..176] Kampman) (NNP:[177..178] E) (,:[178..179] ,) (NNP:[180..183] van) (NNP:[184..190] Geloof) (NNP:[191..192] W) (,:[192..193] ,) (NNP:[194..201] Grubben) (NNP:[202..204] M,) (NNP:[205..208] Kok) (NNP:[209..210] F) (,:[210..211] ,) (NNP:[212..215] van) (NNP:[216..222] Muijen) (NNP:[223..224] G) (,:[224..225] ,) (NNP:[226..235] Nagengast) (NNP:[237..238] F) (,:[238..239] ,) (NNP:[240..245] Vasen) (NNP:[246..247] H) (,:[247..248] ,) (VBD:[249..254] van't) (NNP:[255..259] Veer) (NNP:[260..262] P.))) ;section 3 Span:266..352 ;Division of Human Nutrition and Epidemiology, Wageningen University, The ;Netherlands. (SEC (FRAG (NNP:[266..274] Division) (IN:[275..277] of) (NNP:[278..283] Human) (NNP:[284..293] Nutrition) (CC:[294..297] and) (NNP:[298..310] Epidemiology) (,:[310..311] ,) (NNP:[312..322] Wageningen) (NNP:[323..333] University) (,:[333..334] ,) (DT:[335..338] The) (NNP:[340..351] Netherlands) (.:[351..352] .))) ;sentence 4 Span:356..541 ;K-ras and p53 gene mutations are known to occur in high frequencies in ;sporadic colorectal cancers, but findings are inconsistent in hereditary ;nonpolyposis colorectal cancer (HNPCC). ;[356..361]:gene-rna:"K-ras" ;[366..369]:gene-rna:"p53" ;[427..455]:malignancy:"sporadic colorectal cancers" ;[490..532]:malignancy:"hereditary nonpolyposis colorectal cancer" ;[534..539]:malignancy:"HNPCC" (SENT (S (S (NP-SBJ-2 (NP (NN:[356..361] K-ras) (NML-1 (-NONE-:[361..361] *P*))) (CC:[362..365] and) (NP (NN:[366..369] p53) (NML-1 (NN:[370..374] gene) (NNS:[375..384] mutations)))) (VP (VBP:[385..388] are) (VP (VBN:[389..394] known) (S (NP-SBJ-2 (-NONE-:[394..394] *)) (VP (TO:[395..397] to) (VP (VB:[398..403] occur) (PP (IN:[404..406] in) (NP (JJ:[407..411] high) (NNS:[412..423] frequencies))) (PP-LOC (IN:[424..426] in) (NP (JJ:[427..435] sporadic) (JJ:[437..447] colorectal) (NNS:[448..455] cancers))))))))) (,:[455..456] ,) (CC:[457..460] but) (S (NP-SBJ (NNS:[461..469] findings)) (VP (VBP:[470..473] are) (ADJP-PRD (JJ:[474..486] inconsistent)) (PP (IN:[487..489] in) (NP (NP (JJ:[490..500] hereditary) (NN:[501..513] nonpolyposis) (JJ:[515..525] colorectal) (NN:[526..532] cancer)) (NP (-LRB-:[533..534] -LRB-) (NN:[534..539] HNPCC) (-RRB-:[539..540] -RRB-)))))) (.:[540..541] .))) ;sentence 5 Span:542..796 ;We compared K-ras codon 12 and 13 gene mutations and p53 protein ;overexpression in 48 HNPCC (positive for Amsterdam criteria) and 59 sporadic ;colorectal adenomas, to examine whether they may represent similar or ;different molecular pathways to cancer. ;[554..559]:gene-rna:"K-ras" ;[560..568]:variation-location:"codon 12" ;[560..565]...[573..575]:variation-location:"codon"..."13" ;[581..590]:variation-event:"mutations" ;[596..599]:gene-protein:"p53" ;[629..634]:malignancy:"HNPCC" ;[677..705]:malignancy:"sporadic colorectal adenomas" (SENT (S (NP-SBJ (PRP:[542..544] We)) (VP (VBD:[545..553] compared) (NP (NP (NP (NML-1 (NN:[554..559] K-ras)) (NML (NML-2 (NN:[560..565] codon)) (CD:[566..568] 12)) (NML-3 (-NONE-:[568..568] *P*))) (CC:[569..572] and) (NP (NML-1 (-NONE-:[572..572] *P*)) (NML (NML-2 (-NONE-:[572..572] *P*)) (CD:[573..575] 13)) (NML-3 (NN:[576..580] gene) (NNS:[581..590] mutations)))) (CC:[591..594] and) (NP (NN:[596..599] p53) (NML (NN:[600..607] protein) (NN:[608..622] overexpression)))) (PP (IN:[623..625] in) (NP (NP (CD:[626..628] 48) (NN:[629..634] HNPCC) (PRN (-LRB-:[635..636] -LRB-) (ADJP (JJ:[636..644] positive) (PP (IN:[645..648] for) (NP (NNP:[649..658] Amsterdam) (NNS:[659..667] criteria)))) (-RRB-:[667..668] -RRB-))) (CC:[669..672] and) (NP (CD:[673..675] 59) (JJ:[677..685] sporadic) (JJ:[686..696] colorectal) (NNS:[697..705] adenomas)))) (,:[705..706] ,) (S-PRP (NP-SBJ (-NONE-:[706..706] *)) (VP (TO:[707..709] to) (VP (VB:[710..717] examine) (SBAR (IN:[718..725] whether) (S (NP-SBJ (PRP:[726..730] they)) (VP (MD:[731..734] may) (VP (VB:[735..744] represent) (NP (NP (NP (JJ:[745..752] similar) (NML-4 (-NONE-:[752..752] *P*))) (CC:[753..755] or) (NP (JJ:[757..766] different) (NML-4 (JJ:[767..776] molecular) (NNS:[777..785] pathways)))) (PP (TO:[786..788] to) (NP (NN:[789..795] cancer)))))))))))) (.:[795..796] .))) ;sentence 6 Span:797..899 ;In sporadic adenomas K-ras mutations were detected in 32% and p53 ;overexpression in 31% of the cases. ;[800..817]:malignancy:"sporadic adenomas" ;[818..823]:gene-rna:"K-ras" ;[860..863]:gene-protein:"p53" (SENT (S (PP (IN:[797..799] In) (NP (JJ:[800..808] sporadic) (NNS:[809..817] adenomas))) (S (NP-SBJ-1=2 (NN:[818..823] K-ras) (NNS:[824..833] mutations)) (VP (VBD:[835..839] were) (VP (VBN:[840..848] detected) (NP-1 (-NONE-:[848..848] *)) (PP=3 (IN:[849..851] in) (NP (NP (CD:[852..854] 32) (NN:[854..855] %)) (PP-4 (-NONE-:[855..855] *RNR*))))))) (CC:[856..859] and) (S (NP-SBJ=2 (NN:[860..863] p53) (NN:[864..878] overexpression)) (PP=3 (IN:[879..881] in) (NP (NP (CD:[882..884] 31) (NN:[884..885] %)) (PP-4 (-NONE-:[885..885] *RNR*))))) (PP-4 (IN:[886..888] of) (NP (DT:[889..892] the) (NNS:[893..898] cases))) (.:[898..899] .))) ;sentence 7 Span:900..992 ;Similarly, K-ras mutations and p53 overexpression were both found in 25% of ;HNPCC adenomas. ;[912..917]:gene-rna:"K-ras" ;[932..935]:gene-protein:"p53" ;[977..991]:malignancy:"HNPCC adenomas" (SENT (S (ADVP (RB:[900..909] Similarly)) (,:[909..910] ,) (NP-SBJ-1 (NP (NN:[912..917] K-ras) (NNS:[918..927] mutations)) (CC:[928..931] and) (NP (NN:[932..935] p53) (NN:[936..950] overexpression))) (VP (VBD:[951..955] were) (DT:[956..960] both) (VP (VBN:[961..966] found) (NP-1 (-NONE-:[966..966] *)) (PP (IN:[967..969] in) (NP (NP (CD:[970..972] 25) (NN:[972..973] %)) (PP (IN:[974..976] of) (NP (NN:[977..982] HNPCC) (NNS:[983..991] adenomas))))))) (.:[991..992] .))) ;sentence 8 Span:994..1103 ;The frequencies of these abnormalities were not significantly different ;between HNPCC and sporadic adenomas. ;[1075..1080]:malignancy:"HNPCC" ;[1085..1102]:malignancy:"sporadic adenomas" (SENT (S (NP-SBJ (NP (DT:[994..997] The) (NNS:[998..1009] frequencies)) (PP (IN:[1010..1012] of) (NP (DT:[1013..1018] these) (NNS:[1019..1032] abnormalities)))) (VP (VBD:[1033..1037] were) (RB:[1038..1041] not) (ADJP-PRD (RB:[1042..1055] significantly) (JJ:[1056..1065] different) (PP (IN:[1066..1073] between) (NP (NP (NN:[1075..1080] HNPCC)) (CC:[1081..1084] and) (NP (JJ:[1085..1093] sporadic) (NNS:[1094..1102] adenomas)))))) (.:[1102..1103] .))) ;sentence 9 Span:1104..1198 ;When taking differences in adenoma size into account, the frequencies were ;even more similar. ;[1131..1138]:malignancy:"adenoma" (SENT (S (SBAR-ADV (WRB:[1104..1108] When) (S (NP-SBJ (-NONE-:[1108..1108] *)) (VP (VBG:[1109..1115] taking) (NP (NP (NNS:[1116..1127] differences)) (PP (IN:[1128..1130] in) (NP (NN:[1131..1138] adenoma) (NN:[1139..1143] size)))) (PP (IN:[1144..1148] into) (NP (NN:[1150..1157] account)))))) (,:[1157..1158] ,) (NP-SBJ (DT:[1159..1162] the) (NNS:[1163..1174] frequencies)) (VP (VBD:[1175..1179] were) (ADJP-PRD (ADVP (RB:[1180..1184] even) (RBR:[1185..1189] more)) (JJ:[1190..1197] similar))) (.:[1197..1198] .))) ;sentence 10 Span:1199..1361 ;In conclusion, these results suggest a similar molecular pathway to adenomas ;in HNPCC and sporadic carcinogenesis, with respect to involvement of K-ras ;and p53. ;[1268..1276]:malignancy:"adenomas" ;[1280..1285]:malignancy:"HNPCC" ;[1347..1352]:gene-rna:"K-ras" ;[1357..1360]:gene-rna:"p53" (SENT (S (PP (IN:[1199..1201] In) (NP (NN:[1202..1212] conclusion))) (,:[1212..1213] ,) (NP-SBJ (DT:[1214..1219] these) (NNS:[1220..1227] results)) (VP (VBP:[1229..1236] suggest) (NP (DT:[1237..1238] a) (JJ:[1239..1246] similar) (JJ:[1247..1256] molecular) (NN:[1257..1264] pathway)) (PP (TO:[1265..1267] to) (NP (NNS:[1268..1276] adenomas))) (PP (IN:[1277..1279] in) (NP (NP (NN:[1280..1285] HNPCC)) (CC:[1286..1289] and) (NP (JJ:[1290..1298] sporadic) (NN:[1300..1314] carcinogenesis)))) (,:[1314..1315] ,) (PP (IN:[1316..1320] with) (NP (NP (NN:[1321..1328] respect)) (PP (TO:[1329..1331] to) (NP (NP (NN:[1332..1343] involvement)) (PP (IN:[1344..1346] of) (NP (NP (NN:[1347..1352] K-ras)) (CC:[1353..1356] and) (NP (NN:[1357..1360] p53))))))))) (.:[1360..1361] .))) ;section 11 Span:1365..1410 ;PMID: 11215737 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1365..1369] PMID) (::[1369..1370] :) (CD:[1371..1379] 11215737) (NN:[1380..1381] -LSB-) (NNP:[1381..1387] PubMed) (::[1388..1389] -) (NN:[1390..1397] indexed) (IN:[1398..1401] for) (NNP:[1402..1410] MEDLINE-RSB-)))