Leukemia  1997 Jun;11(6):863-5 

No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic
syndromes.

Mitani K, Hangaishi A, Imamura N, Miyagawa K, Ogawa S, Kanda Y, Yazaki Y, Hirai
H.

Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo,
Bunkyo-ku, Japan.

Mutations of the N-ras oncogene and p53 tumor suppressor gene were
simultaneously investigated in bone marrow cells from 44 patients with
myelodysplastic syndrome (MDS) or MDS-derived leukemia by single-strand
conformation polymorphism (SSCP) analysis followed by direct sequencing. The
mutations of the N-ras gene were detected only in two cases with MDS-derived
leukemia. Three patients with MDS-derived leukemia and one with refractory
anemia with excess of blasts exhibited five mutations of the p53 gene. No
concomitant mutations of both genes were observed in our study, suggesting that
alterations of both genes could play an important role in the progression of MDS
in a non-cooperative manner.

PMID: 9177441 [PubMed - indexed for MEDLINE]