Oncol Rep  2001 Jan-Feb;8(1):89-92 

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15
human pancreatic cancer cell lines.

Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A.

Department of Molecular Pathology, Tohoku University School of Medicine,
Aoba-ku, Sendai 980-8575, Japan.

Human pancreatic cancer is one of the most malignant diseases in the world. In
order to save patients with pancreatic cancer, it is necessary to develop novel
methods for treatment. For such a purpose, a series of well-characterized cancer
cell lines are of great help for in vitro studies that are generally the first
step in approaching the invention of novel methods for treatment. In the present
study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations
of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for
mutation in pancreatic cancer; these cell lines are useful resources in cancer
research.

PMID: 11115575 [PubMed - indexed for MEDLINE]