;PMID: 7592017 ;source_file_1924.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..42] = [t:0..42] ;1)sentence:[e:48..84] = [t:48..84] ;2)sentence:[e:85..87] = [t:85..87] ;3)sentence:[e:88..181] = [t:88..181] ;4)section:[e:185..270] = [t:185..270] ;5)section:[e:274..360] = [t:274..360] ;6)sentence:[e:364..449] = [t:364..449] ;7)sentence:[e:450..568] = [t:450..568] ;8)sentence:[e:569..751] = [t:569..751] ;9)sentence:[e:753..833] = [t:753..833] ;10)section:[e:837..881] = [t:837..881] ;section 0 Span:0..42 ;J Antibiot (Tokyo). 1995 Aug;48(8):757-62. (SEC (FRAG (NNP:[0..1] J) (NNP:[2..10] Antibiot) (-LRB-:[11..12] -LRB-) (NN:[12..17] Tokyo) (NN:[17..18] -RRB-) (.:[18..19] .) (CD:[20..24] 1995) (.:[25..31] Aug;48) (-LRB-:[31..32] -LRB-) (CD:[32..33] 8) (-RRB-:[33..34] -RRB-) (CD:[34..38] :757) (::[38..39] -) (CD:[39..41] 62) (.:[41..42] .))) ;sentence 1 Span:48..84 ;A new aromatase inhibitor, FR901537. ;[54..63]:substance:"aromatase" ;[64..73]:substance:"inhibitor" ;[75..83]:substance:"FR901537" (SENT (NP-HLN (NP (DT:[48..49] A) (JJ:[50..53] new) (NN:[54..63] aromatase) (NN:[64..73] inhibitor)) (,:[73..74] ,) (NP (NN:[75..83] FR901537)) (.:[83..84] .))) ;sentence 2 Span:85..87 ;I. (SENT (NP-HLN (CD:[85..86] I) (.:[86..87] .))) ;sentence 3 Span:88..181 ;Taxonomy, fermentation, isolation, physiochemical characteristics and ;biological activities. (SENT (NP-HLN (NP (NN:[88..96] Taxonomy)) (,:[96..97] ,) (NP (NN:[98..110] fermentation)) (,:[110..111] ,) (NP (NN:[112..121] isolation)) (,:[121..122] ,) (NP (JJ:[124..138] physiochemical) (NNS:[139..154] characteristics)) (CC:[155..158] and) (NP (JJ:[159..169] biological) (NNS:[170..180] activities)) (.:[180..181] .))) ;section 4 Span:185..270 ;Oohata N, Hori Y, Yamagishi Y, Fujita T, Takase S, Yamashita M, Terano H, ;Okuhara M. (SEC (FRAG (NNP:[185..191] Oohata) (NNP:[192..193] N) (,:[193..194] ,) (NNP:[195..199] Hori) (NNP:[200..201] Y) (,:[201..202] ,) (NNP:[203..212] Yamagishi) (NNP:[213..214] Y) (,:[214..215] ,) (NNP:[216..222] Fujita) (NNP:[223..224] T) (,:[224..225] ,) (NNP:[226..232] Takase) (NNP:[233..234] S) (,:[234..235] ,) (NNP:[236..245] Yamashita) (NNP:[246..248] M,) (NNP:[249..255] Terano) (NNP:[256..258] H,) (NNP:[260..267] Okuhara) (NNP:[268..270] M.))) ;section 5 Span:274..360 ;Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., ;Ibaraki, Japan. (SEC (FRAG (NNP:[274..285] Exploratory) (NNP:[286..294] Research) (NNP:[295..307] Laboratories) (,:[307..308] ,) (NNP:[309..317] Fujisawa) (NNP:[318..332] Pharmaceutical) (NNP:[333..336] Co.) (,:[336..337] ,) (NNP:[338..342] Ltd.) (,:[342..343] ,) (NNP:[344..351] Ibaraki) (,:[351..352] ,) (NNP:[354..359] Japan) (.:[359..360] .))) ;sentence 6 Span:364..449 ;FR901537 is a new aromatase inhibitor produced by a bacterium Bacillus sp. ;No. 3072. ;[364..372]:substance:"FR901537" ;[382..391]:substance:"aromatase" ;[392..401]:substance:"inhibitor" (SENT (S (NP-SBJ (NN:[364..372] FR901537)) (VP (VBZ:[373..375] is) (NP-PRD (NP (DT:[376..377] a) (JJ:[378..381] new) (NN:[382..391] aromatase) (NN:[392..401] inhibitor)) (VP (VBN:[402..410] produced) (NP (-NONE-:[410..410] *)) (PP (IN:[411..413] by) (NP-LGS (NP (DT:[414..415] a) (NN:[416..425] bacterium)) (NP (NNP:[426..434] Bacillus) (NNP:[435..438] sp.) (NN:[439..442] No.) (CD:[444..448] 3072))))))) (.:[448..449] .))) ;sentence 7 Span:450..568 ;Structural studies of FR901537 suggested that it was a novel naphthol ;derivative having pantetheine in its structure. ;[472..480]:substance:"FR901537" ;[511..531]:substance:"naphthol derivative" ;[539..550]:substance:"pantetheine" (SENT (S (NP-SBJ (NP (JJ:[450..460] Structural) (NNS:[461..468] studies)) (PP (IN:[469..471] of) (NP (NN:[472..480] FR901537)))) (VP (VBD:[481..490] suggested) (SBAR (IN:[491..495] that) (S (NP-SBJ (PRP:[496..498] it)) (VP (VBD:[499..502] was) (NP-PRD (NP (DT:[503..504] a) (JJ:[505..510] novel) (NN:[511..519] naphthol) (NN:[521..531] derivative)) (VP (VBG:[532..538] having) (NP (NN:[539..550] pantetheine)) (PP (IN:[551..553] in) (NP (PRP$:[554..557] its) (NN:[558..567] structure))))))))) (.:[567..568] .))) ;sentence 8 Span:569..751 ;FR901537 showed a potent inhibitory activity against aromatase from human ;placenta or rat ovary, but did not inhibit the activity of 11 ;beta-hydroxylase from bovine adrenal cortex. ;[569..577]:substance:"FR901537" ;[623..632]:substance:"aromatase" ;[704..723]:substance:"11 beta-hydroxylase" (SENT (S (NP-SBJ (NN:[569..577] FR901537)) (VP (VP (VBD:[578..584] showed) (NP (NP (DT:[585..586] a) (JJ:[587..593] potent) (JJ:[595..605] inhibitory) (NN:[606..614] activity)) (PP (IN:[615..622] against) (NP (NP (NN:[623..632] aromatase)) (PP (IN:[633..637] from) (NP (NP (JJ:[638..643] human) (NN:[644..652] placenta)) (CC:[653..655] or) (NP (NN:[656..659] rat) (NN:[660..665] ovary)))))))) (,:[665..666] ,) (CC:[667..670] but) (VP (VBD:[671..674] did) (RB:[676..679] not) (VP (VB:[680..687] inhibit) (NP (NP (DT:[688..691] the) (NN:[692..700] activity)) (PP (IN:[701..703] of) (NP (NP (CD:[704..706] 11) (NN:[707..723] beta-hydroxylase)) (PP (IN:[724..728] from) (NP (JJ:[729..735] bovine) (JJ:[736..743] adrenal) (NN:[744..750] cortex))))))))) (.:[750..751] .))) ;sentence 9 Span:753..833 ;Lineweaver-Burk plot analysis revealed that FR901537 is a competitive ;inhibitor. ;[797..805]:substance:"FR901537" ;[823..832]:substance:"inhibitor" (SENT (S (NP-SBJ (NML (NNP:[753..763] Lineweaver) (HYPH:[763..764] -) (NNP:[764..768] Burk)) (NN:[769..773] plot) (NN:[774..782] analysis)) (VP (VBD:[783..791] revealed) (SBAR (IN:[792..796] that) (S (NP-SBJ (NN:[797..805] FR901537)) (PP (VBZ:[806..808] is) (NP-PRD (DT:[809..810] a) (JJ:[811..822] competitive) (NN:[823..832] inhibitor)))))) (.:[832..833] .))) ;section 10 Span:837..881 ;PMID: 7592017 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[837..841] PMID) (::[841..842] :) (CD:[843..850] 7592017) (-LRB-:[851..852] -LSB-) (NNP:[852..858] PubMed) (HYPH:[859..860] -) (NN:[861..868] indexed) (IN:[869..872] for) (NNP:[873..880] MEDLINE) (-RRB-:[880..881] -RSB-)))