;PMID: 10199577 ;source_file_1914.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..35] = [t:0..35] ;1)sentence:[e:41..145] = [t:41..145] ;2)section:[e:149..178] = [t:149..178] ;3)section:[e:182..293] = [t:182..293] ;4)sentence:[e:297..472] = [t:297..472] ;5)sentence:[e:473..771] = [t:473..771] ;6)sentence:[e:772..926] = [t:772..926] ;7)sentence:[e:927..1076] = [t:927..1076] ;8)sentence:[e:1077..1335] = [t:1077..1335] ;9)sentence:[e:1336..1411] = [t:1336..1411] ;10)sentence:[e:1412..1476] = [t:1412..1476] ;11)sentence:[e:1477..1573] = [t:1477..1573] ;12)sentence:[e:1574..1677] = [t:1574..1677] ;13)section:[e:1681..1726] = [t:1681..1726] ;section 0 Span:0..35 ;Toxicology. 1999 Jan 1;132(1):9-18. (SEC (FRAG (NNP:[0..10] Toxicology) (.:[10..11] .) (CD:[12..16] 1999) (CC:[17..20] Jan) (CD:[21..26] 1;132) (-LRB-:[26..27] -LRB-) (CD:[27..28] 1) (-RRB-:[28..29] -RRB-) (::[29..30] :) (CD:[30..32] 9-) (CD:[32..34] 18) (.:[34..35] .))) ;sentence 1 Span:41..145 ;Trichloroethylene inhibits aldehyde dehydrogenase only for aliphatic ;aldehydes of short chains in rats. ;[41..58]:substance:"Trichloroethylene" ;[68..90]:substance:"aldehyde dehydrogenase" ;[100..119]:substance:"aliphatic aldehydes" (SENT (S-HLN (NP-SBJ (NN:[41..58] Trichloroethylene)) (VP (VBZ:[59..67] inhibits) (NP (NN:[68..76] aldehyde) (NN:[77..90] dehydrogenase)) (PP (RB:[91..95] only) (IN:[96..99] for) (NP (NP (JJ:[100..109] aliphatic) (NNS:[110..119] aldehydes)) (PP (IN:[121..123] of) (NP (JJ:[124..129] short) (NNS:[130..136] chains))))) (PP-LOC (IN:[137..139] in) (NP (NNS:[140..144] rats)))) (.:[144..145] .))) ;section 2 Span:149..178 ;Wang RS, Nakajima T, Honma T. (SEC (FRAG (NNP:[149..153] Wang) (NNP:[154..156] RS) (,:[156..157] ,) (NNP:[158..166] Nakajima) (NNP:[167..168] T) (,:[168..169] ,) (NNP:[170..175] Honma) (NNP:[176..178] T.))) ;section 3 Span:182..293 ;Division of Health Effects Research, National Institute of Industrial Health, ; Kawasaki, Japan. wang@niih.go.jp (SEC (FRAG (NNP:[182..190] Division) (IN:[191..193] of) (NNP:[194..200] Health) (NNS:[201..208] Effects) (NNP:[209..217] Research) (,:[217..218] ,) (NNP:[219..227] National) (NNP:[228..237] Institute) (IN:[238..240] of) (NNP:[241..251] Industrial) (NNP:[252..258] Health) (,:[258..259] ,) (NNP:[261..269] Kawasaki) (,:[269..270] ,) (NNP:[271..276] Japan) (.:[276..277] .) (``:[278..290] wang@niih.go) (NN:[290..293] .jp))) ;sentence 4 Span:297..472 ;The effects of trichloroethylene (TCE) administration on aldehyde ;dehydrogenase (ALDH) and cytochrome P450 isozymes were studied in rats and ;compared with those of methanol. ;[312..329]:substance:"trichloroethylene" ;[331..334]:substance:"TCE" ;[354..376]:substance:"aldehyde dehydrogenase" ;[379..383]:substance:"ALDH" ;[389..413]:cyp450:"cytochrome P450 isozymes" ;[463..471]:substance:"methanol" (SENT (S (NP-SBJ-1 (NP (DT:[297..300] The) (NNS:[301..308] effects)) (PP (IN:[309..311] of) (NP (NP (NML (NML (NN:[312..329] trichloroethylene)) (NML (-LRB-:[330..331] -LRB-) (NN:[331..334] TCE) (-RRB-:[334..335] -RRB-))) (NN:[336..350] administration)) (PP (IN:[351..353] on) (NP (NP (NP (NN:[354..362] aldehyde) (NN:[363..376] dehydrogenase)) (NP (-LRB-:[378..379] -LRB-) (NN:[379..383] ALDH) (-RRB-:[383..384] -RRB-))) (CC:[385..388] and) (NP (NML (NN:[389..399] cytochrome) (NN:[400..404] P450)) (NNS:[405..413] isozymes))))))) (VP (VBD:[414..418] were) (VP (VP (VBN:[419..426] studied) (NP-1 (-NONE-:[426..426] *)) (PP-LOC (IN:[427..429] in) (NP-SBJ (NNS:[430..434] rats)))) (CC:[435..438] and) (VP (VBN:[439..447] compared) (NP-1 (-NONE-:[447..447] *)) (-NONE-:[447..447] *P*) (PP-CLR (IN:[448..452] with) (NP (NP (DT:[453..458] those)) (PP (IN:[460..462] of) (NP (NN:[463..471] methanol)))))))) (.:[471..472] .))) ;sentence 5 Span:473..771 ;Intragastric administration of TCE to rats at 0.05 or 0.2 ml/kg for 1 week ;significantly inhibited ALDH activity for aliphatic aldehydes of short ;chains in the mitochondrial and cytosolic fractions of rat liver, ;respectively, but had no effect on the activity for long chain aliphatic ;aldehydes. ;[504..507]:substance:"TCE" ;[519..523]:quantitative-value:"0.05" ;[527..530]:quantitative-value:"0.2" ;[531..536]:quantitative-units:"ml/kg" ;[542..543]:quantitative-value:"1" ;[544..548]:quantitative-units:"week" ;[573..577]:substance:"ALDH" ;[591..610]:substance:"aliphatic aldehydes" ;[740..770]:substance:"long chain aliphatic aldehydes" (SENT (S (NP-SBJ (NP (JJ:[473..485] Intragastric) (NN:[486..500] administration)) (PP (IN:[501..503] of) (NP (NN:[504..507] TCE))) (PP (TO:[508..510] to) (NP (NNS:[511..515] rats))) (PP (IN:[516..518] at) (NP (NP (NP (CD:[519..523] 0.05) (NML-2 (-NONE-:[523..523] *P*))) (PP-3 (-NONE-:[523..523] *P*))) (CC:[524..526] or) (NP (NP (CD:[527..530] 0.2) (NML-2 (NN:[531..533] ml))) (PP-3 (SYM:[533..534] /) (NP (NN:[534..536] kg)))))) (PP-TMP (IN:[537..540] for) (NP (CD:[542..543] 1) (NN:[544..548] week)))) (VP (VP (ADVP (RB:[549..562] significantly)) (VBD:[563..572] inhibited) (NP (NN:[573..577] ALDH) (NN:[578..586] activity)) (PP (IN:[587..590] for) (NP (NP (JJ:[591..600] aliphatic) (NNS:[601..610] aldehydes)) (PP (IN:[611..613] of) (NP (JJ:[614..619] short) (NNS:[621..627] chains))))) (PP (IN:[628..630] in) (NP (NP (DT:[631..634] the) (NML (NML (JJ:[635..648] mitochondrial) (NML-1 (-NONE-:[648..648] *P*))) (CC:[649..652] and) (NML (JJ:[653..662] cytosolic) (NML-1 (NNS:[663..672] fractions))))) (PP (IN:[673..675] of) (NP (NN:[676..679] rat) (NN:[680..685] liver))) (,:[685..686] ,) (ADVP (RB:[687..699] respectively))))) (,:[699..700] ,) (CC:[702..705] but) (VP (VBD:[706..709] had) (NP (NP (DT:[710..712] no) (NN:[713..719] effect)) (PP (IN:[720..722] on) (NP (DT:[723..726] the) (NN:[727..735] activity))) (PP (IN:[736..739] for) (NP (NML (JJ:[740..744] long) (NN:[745..750] chain)) (JJ:[751..760] aliphatic) (NNS:[761..770] aldehydes)))))) (.:[770..771] .))) ;sentence 6 Span:772..926 ;ALDH activity catalyzing the metabolism of some aromatic aldehydes was even ;induced by TCE. Microsomal ALDH activity was not decreased by TCE ;treatment. ;[772..776]:substance:"ALDH" ;[821..839]:substance:"aromatic aldehydes" ;[861..864]:substance:"TCE" ;[877..881]:substance:"ALDH" ;[912..915]:substance:"TCE" (SENT (S (NP-SBJ-2 (NP (NN:[772..776] ALDH) (NN:[778..786] activity)) (VP (VBG:[787..797] catalyzing) (NP (NP (DT:[798..801] the) (NN:[802..812] metabolism)) (PP (IN:[813..815] of) (NP (DT:[816..820] some) (JJ:[821..829] aromatic) (NNS:[830..839] aldehydes)))))) (VP (VBD:[840..843] was) (ADVP (RB:[844..848] even)) (VP (VBN:[849..856] induced) (NP-2 (-NONE-:[856..856] *)) (PP (IN:[858..860] by) (NP-LGS (NN:[861..864] TCE))))) (.:[864..865] .)) (S (NP-SBJ-1 (JJ:[866..876] Microsomal) (NN:[877..881] ALDH) (NN:[882..890] activity)) (VP (VBD:[891..894] was) (RB:[895..898] not) (VP (VBN:[899..908] decreased) (NP-1 (-NONE-:[908..908] *)) (PP (IN:[909..911] by) (NP-LGS (NN:[912..915] TCE) (NN:[916..925] treatment))))) (.:[925..926] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[772..926]::S:S: ;sentence 7 Span:927..1076 ;A kinetic study showed that the low-Km isozyme of ALDH for propionaldehyde ;in mitochondrial and cytosolic fractions was inhibited by TCE treatment. ;[964..966]:quantitative-name:"Km" ;[967..974]:substance:"isozyme" ;[978..982]:substance:"ALDH" ;[987..1002]:substance:"propionaldehyde" ;[1062..1065]:substance:"TCE" (SENT (S (NP-SBJ (DT:[927..928] A) (JJ:[929..936] kinetic) (NN:[938..943] study)) (VP (VBD:[944..950] showed) (SBAR (IN:[951..955] that) (S (NP-SBJ-2 (NP (DT:[956..959] the) (NML (JJ:[960..963] low) (HYPH:[963..964] -) (NN:[964..966] Km)) (NN:[967..974] isozyme)) (PP (IN:[975..977] of) (NP (NN:[978..982] ALDH))) (PP (IN:[983..986] for) (NP (NN:[987..1002] propionaldehyde))) (PP-LOC (IN:[1003..1005] in) (NP (NP (JJ:[1007..1020] mitochondrial) (NML-1 (-NONE-:[1020..1020] *P*))) (CC:[1021..1024] and) (NP (JJ:[1025..1034] cytosolic) (NML-1 (NNS:[1035..1044] fractions)))))) (VP (VBD:[1045..1048] was) (VP (VBN:[1049..1058] inhibited) (NP-2 (-NONE-:[1058..1058] *)) (PP (IN:[1059..1061] by) (NP-LGS (NN:[1062..1065] TCE) (NN:[1066..1075] treatment)))))))) (.:[1075..1076] .))) ;sentence 8 Span:1077..1335 ;Addition of TCE, trichloroethanol or trichloroacetic acid to the in vitro ;assay system did not affect the activity for acetaldehyde, but chloral ;hydrate at 0.02 mM decreased the activity by 42 and 35% in cytosol and the ;700 x g supernatant, respectively. ;[1090..1094]:substance:"TCE," ;[1095..1111]:substance:"trichloroethanol" ;[1115..1135]:substance:"trichloroacetic acid" ;[1198..1210]:substance:"acetaldehyde" ;[1216..1231]:substance:"chloral hydrate" ;[1235..1239]:quantitative-value:"0.02" ;[1240..1242]:quantitative-units:"mM" ;[1270..1272]...[1279..1280]:quantitative-value:"42"..."%" ;[1277..1280]:quantitative-value:"35%" ;[1300..1305]:quantitative-value:"700 x" ;[1306..1307]:quantitative-units:"g" (SENT (S (S (NP-SBJ (NP (NN:[1077..1085] Addition)) (PP (IN:[1087..1089] of) (NP (NP (NN:[1090..1093] TCE)) (,:[1093..1094] ,) (NP (NN:[1095..1111] trichloroethanol)) (CC:[1112..1114] or) (NP (JJ:[1115..1130] trichloroacetic) (NN:[1131..1135] acid)))) (PP (TO:[1136..1138] to) (NP (DT:[1139..1142] the) (ADJP (FW:[1143..1145] in) (FW:[1146..1151] vitro)) (NN:[1152..1157] assay) (NN:[1158..1164] system)))) (VP (VBD:[1166..1169] did) (RB:[1170..1173] not) (VP (VB:[1174..1180] affect) (NP (DT:[1181..1184] the) (NN:[1185..1193] activity)) (PP (IN:[1194..1197] for) (NP (NN:[1198..1210] acetaldehyde)))))) (,:[1210..1211] ,) (CC:[1212..1215] but) (S (NP-SBJ (NP (JJ:[1216..1223] chloral) (NN:[1224..1231] hydrate)) (PP (IN:[1232..1234] at) (NP (CD:[1235..1239] 0.02) (NN:[1240..1242] mM)))) (VP (VBD:[1244..1253] decreased) (NP (DT:[1254..1257] the) (NN:[1258..1266] activity)) (PP (IN:[1267..1269] by) (NP-EXT (NP (CD:[1270..1272] 42) (NML-1 (-NONE-:[1272..1272] *P*))) (CC:[1273..1276] and) (NP (CD:[1277..1279] 35) (NML-1 (NN:[1279..1280] %))))) (PP-LOC (IN:[1281..1283] in) (NP (NP (NN:[1284..1291] cytosol)) (CC:[1292..1295] and) (NP (DT:[1296..1299] the) (NML (CD:[1300..1303] 700) (SYM:[1304..1305] x) (NN:[1306..1307] g)) (NN:[1308..1319] supernatant)))) (,:[1319..1320] ,) (ADVP (RB:[1322..1334] respectively)))) (.:[1334..1335] .))) ;sentence 9 Span:1336..1411 ;Methanol treatment, on the other hand, had no effect on any ALDH activity. ;[1336..1344]:substance:"Methanol" ;[1396..1400]:substance:"ALDH" (SENT (S (NP-SBJ (NN:[1336..1344] Methanol) (NN:[1345..1354] treatment)) (,:[1354..1355] ,) (PP (IN:[1356..1358] on) (NP (DT:[1359..1362] the) (JJ:[1363..1368] other) (NN:[1369..1373] hand))) (VP (,:[1373..1374] ,) (VBD:[1375..1378] had) (NP (DT:[1379..1381] no) (NN:[1382..1388] effect)) (PP (IN:[1389..1391] on) (NP (DT:[1392..1395] any) (NN:[1396..1400] ALDH) (NN:[1402..1410] activity)))) (.:[1410..1411] .))) ;sentence 10 Span:1412..1476 ;Both TCE and methanol significantly induced CYP2E1 in rat liver. ;[1417..1420]:substance:"TCE" ;[1425..1433]:substance:"methanol" ;[1456..1462]:cyp450:"CYP2E1" (SENT (S (NP-SBJ (CC:[1412..1416] Both) (NML (NN:[1417..1420] TCE) (CC:[1421..1424] and) (NN:[1425..1433] methanol))) (ADVP (RB:[1434..1447] significantly)) (VP (VBD:[1448..1455] induced) (NP (NN:[1456..1462] CYP2E1)) (PP-LOC (IN:[1463..1465] in) (NP (NN:[1466..1469] rat) (NN:[1470..1475] liver)))) (.:[1475..1476] .))) ;sentence 11 Span:1477..1573 ;The combined effects of TCE on ALDH and cytochrome P450 may account for the ;degreasers' flush. ;[1502..1505]:substance:"TCE" ;[1509..1513]:substance:"ALDH" ;[1518..1533]:cyp450:"cytochrome P450" (SENT (S (NP-SBJ (NP (DT:[1477..1480] The) (VBN:[1482..1490] combined) (NNS:[1491..1498] effects)) (PP (IN:[1499..1501] of) (NP (NN:[1502..1505] TCE))) (PP (IN:[1506..1508] on) (NP (NP (NN:[1509..1513] ALDH)) (CC:[1514..1517] and) (NP (NN:[1518..1528] cytochrome) (NN:[1529..1533] P450))))) (VP (MD:[1534..1537] may) (VP (VB:[1538..1545] account) (PP-CLR (IN:[1546..1549] for) (NP (NP (DT:[1550..1553] the) (NNS:[1555..1565] degreasers) (POS:[1565..1566] ')) (NN:[1567..1572] flush))))) (.:[1572..1573] .))) ;sentence 12 Span:1574..1677 ;Exposure to TCE and methanol may result in a change in the metabolism and ;toxicity of other chemicals. ;[1586..1589]:substance:"TCE" ;[1594..1602]:substance:"methanol" (SENT (S (NP-SBJ (NP (NN:[1574..1582] Exposure)) (PP (TO:[1583..1585] to) (NP (NN:[1586..1589] TCE) (CC:[1590..1593] and) (NN:[1594..1602] methanol)))) (VP (MD:[1603..1606] may) (VP (VB:[1607..1613] result) (PP-CLR (IN:[1614..1616] in) (NP (DT:[1617..1618] a) (NN:[1619..1625] change))) (PP (IN:[1626..1628] in) (NP (NP (DT:[1629..1632] the) (NN:[1634..1644] metabolism) (CC:[1645..1648] and) (NN:[1649..1657] toxicity)) (PP (IN:[1658..1660] of) (NP (JJ:[1661..1666] other) (NNS:[1667..1676] chemicals))))))) (.:[1676..1677] .))) ;section 13 Span:1681..1726 ;PMID: 10199577 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1681..1685] PMID) (::[1685..1686] :) (CD:[1687..1695] 10199577) (NN:[1696..1697] -LSB-) (NNP:[1697..1703] PubMed) (::[1704..1705] -) (NN:[1706..1713] indexed) (IN:[1714..1717] for) (NNP:[1718..1726] MEDLINE-RSB-)))