;PMID: 2849519 ;source_file_1888.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..41] = [t:0..41] ;1)sentence:[e:47..103] = [t:47..103] ;2)section:[e:107..140] = [t:107..140] ;3)section:[e:144..207] = [t:144..207] ;4)sentence:[e:211..529] = [t:211..529] ;5)sentence:[e:530..812] = [t:530..812] ;6)sentence:[e:813..907] = [t:813..907] ;7)sentence:[e:908..1040] = [t:908..1040] ;8)sentence:[e:1041..1212] = [t:1041..1212] ;9)section:[e:1216..1234] = [t:1216..1234] ;10)section:[e:1240..1246] = [t:1240..1246] ;11)section:[e:1252..1268] = [t:1252..1268] ;12)section:[e:1272..1316] = [t:1272..1316] ;section 0 Span:0..41 ;Clin Physiol Biochem. 1988;6(3-4):179-87. (SEC (FRAG (NNP:[0..4] Clin) (NNP:[5..12] Physiol) (NNP:[13..20] Biochem) (.:[20..21] .) (CD:[22..26] 1988) (::[26..27] ;) (CD:[27..28] 6) (-LRB-:[28..29] -LRB-) (JJ:[29..31] 3-) (HYPH:[31..33] 4-RRB-) (CD:[33..37] :179) (HYPH:[37..38] -) (CD:[38..40] 87) (.:[40..41] .))) ;sentence 1 Span:47..103 ;Arachidonic acid metabolites and blood pressure control. ;[47..75]:substance:"Arachidonic acid metabolites" (SENT (NP-HLN (NP (NML (JJ:[47..58] Arachidonic) (NN:[59..63] acid)) (NNS:[64..75] metabolites)) (CC:[76..79] and) (NP (NML (NN:[80..85] blood) (NN:[86..94] pressure)) (NN:[95..102] control)) (.:[102..103] .))) ;section 2 Span:107..140 ;McGiff JC, Laniado-Schwartzman M. (SEC (FRAG (NNP:[107..113] McGiff) (NNP:[114..116] JC) (,:[116..117] ,) (NNP:[118..137] Laniado-Schwartzman) (NNP:[138..140] M.))) ;section 3 Span:144..207 ;Department of Pharmacology, New York Medical College, Valhalla. (SEC (FRAG (NNP:[144..154] Department) (IN:[155..157] of) (NNP:[158..170] Pharmacology) (,:[170..171] ,) (NNP:[172..175] New) (NNP:[176..180] York) (NNP:[181..188] Medical) (NNP:[189..196] College) (,:[196..197] ,) (NNP:[198..206] Valhalla) (.:[206..207] .))) ;sentence 4 Span:211..529 ;The medullary portion of the thick ascending limb of the loop of Henle (TALH) ; has one of the highest concentrations of Na+-K+-ATPase found in mammalian ;tissues, reflecting the importance of this nephron segment in the regulation ;of extracellular fluid volume, as active sodium transport is driven by ;Na+-K+-ATPase. ;[331..344]:substance:"Na+-K+-ATPase" ;[484..490]:substance:"sodium" ;[515..528]:substance:"Na+-K+-ATPase" (SENT (S (NP-SBJ (NP (DT:[211..214] The) (JJ:[215..224] medullary) (NN:[225..232] portion)) (PP (IN:[233..235] of) (NP (NP (NP (DT:[236..239] the) (JJ:[240..245] thick) (VBG:[246..255] ascending) (NN:[256..260] limb)) (PP (IN:[261..263] of) (NP (NP (DT:[264..267] the) (NN:[268..272] loop)) (PP (IN:[273..275] of) (NP (NNP:[276..281] Henle)))))) (NP (-LRB-:[282..283] -LRB-) (NN:[283..287] TALH) (-RRB-:[287..288] -RRB-))))) (VP (VBZ:[290..293] has) (NP (NP (CD:[294..297] one)) (PP (IN:[298..300] of) (NP (NP (DT:[301..304] the) (JJS:[305..312] highest) (NNS:[313..327] concentrations)) (PP (IN:[328..330] of) (NP (NN:[331..344] Na+-K+-ATPase))) (VP (VBN:[345..350] found) (NP (-NONE-:[350..350] *)) (PP-LOC (IN:[351..353] in) (NP (JJ:[354..363] mammalian) (NNS:[365..372] tissues))))))) (,:[372..373] ,) (S-ADV (NP-SBJ (-NONE-:[373..373] *)) (VP (VBG:[374..384] reflecting) (NP (NP (DT:[385..388] the) (NN:[389..399] importance)) (PP (IN:[400..402] of) (NP (DT:[403..407] this) (NN:[408..415] nephron) (NN:[416..423] segment))) (PP (IN:[424..426] in) (NP (NP (DT:[427..430] the) (NN:[431..441] regulation)) (PP (IN:[442..444] of) (NP (JJ:[446..459] extracellular) (NN:[460..465] fluid) (NN:[466..472] volume)))))) (,:[472..473] ,) (SBAR-ADV (IN:[474..476] as) (S (NP-SBJ-1 (JJ:[477..483] active) (NN:[484..490] sodium) (NN:[491..500] transport)) (VP (VBZ:[501..503] is) (VP (VBN:[504..510] driven) (NP-1 (-NONE-:[510..510] *)) (PP (IN:[511..513] by) (NP-LGS (NN:[515..528] Na+-K+-ATPase)))))))))) (.:[528..529] .))) ;sentence 5 Span:530..812 ;We have isolated cells derived primarily from the TALH of the outer medulla ;of rabbit kidney and have identified a cytochrome P450-dependent ;monooxygenase system which metabolizes arachidonic acid to two biologically ;active oxygenated peaks, each containing two or more products. ;[646..661]:cyp450:"cytochrome P450" ;[673..686]:substance:"monooxygenase" ;[712..728]:substance:"arachidonic acid" ;[803..811]:substance:"products" (SENT (S (NP-SBJ (PRP:[530..532] We)) (VP (VP (VBP:[533..537] have) (VP (VBN:[538..546] isolated) (NP (NP (NNS:[547..552] cells)) (VP (VBN:[553..560] derived) (NP (-NONE-:[560..560] *)) (ADVP (RB:[561..570] primarily)) (PP-CLR (IN:[571..575] from) (NP (NP (DT:[576..579] the) (NN:[580..584] TALH)) (PP (IN:[585..587] of) (NP (NP (DT:[588..591] the) (JJ:[593..598] outer) (NN:[599..606] medulla)) (PP (IN:[607..609] of) (NP (NN:[610..616] rabbit) (NN:[617..623] kidney))))))))))) (CC:[624..627] and) (VP (VBP:[628..632] have) (VP (VBN:[633..643] identified) (NP (NP (DT:[644..645] a) (ADJP (NML (NN:[646..656] cytochrome) (NN:[657..661] P450)) (HYPH:[661..662] -) (JJ:[662..671] dependent)) (NN:[673..686] monooxygenase) (NN:[687..693] system)) (SBAR (WHNP-1 (WDT:[694..699] which)) (S (NP-SBJ-1 (-NONE-:[699..699] *T*)) (VP (VBZ:[700..711] metabolizes) (NP (JJ:[712..723] arachidonic) (NN:[724..728] acid)) (PP (TO:[729..731] to) (NP (NP (CD:[732..735] two) (ADJP (RB:[736..748] biologically) (JJ:[750..756] active)) (VBN:[757..767] oxygenated) (NNS:[768..773] peaks)) (,:[773..774] ,) (NP (DT:[775..779] each) (VP (VBG:[780..790] containing) (NP (QP (CD:[791..794] two) (CC:[795..797] or) (JJR:[798..802] more)) (NNS:[803..811] products))))))))))))) (.:[811..812] .))) ;sentence 6 Span:813..907 ;One of the peaks potently inhibits cardiac Na+-K+-ATPase and the other ;relaxes blood vessels. ;[857..870]:substance:"Na+-K+-ATPase" (SENT (S (S (NP-SBJ (NP (CD:[813..816] One)) (PP (IN:[817..819] of) (NP (DT:[820..823] the) (NNS:[824..829] peaks)))) (ADVP (RB:[831..839] potently)) (VP (VBZ:[840..848] inhibits) (NP (JJ:[849..856] cardiac) (NN:[857..870] Na+-K+-ATPase)))) (CC:[871..874] and) (S (NP-SBJ (DT:[875..878] the) (NN:[879..884] other)) (VP (VBZ:[885..892] relaxes) (NP (NN:[893..898] blood) (NNS:[899..906] vessels)))) (.:[906..907] .))) ;sentence 7 Span:908..1040 ;We report that formation of these oxygenated arachidonate metabolites is ;stimulated by arginine vasopressin and salmon calcitonin. ;[954..978]:substance:"arachidonate metabolites" ;[997..1017]:substance:"arginine vasopressin" ;[1029..1039]:substance:"calcitonin" (SENT (S (NP-SBJ (PRP:[908..910] We)) (VP (VBP:[912..918] report) (SBAR (IN:[919..923] that) (S (NP-SBJ-1 (NP (NN:[924..933] formation)) (PP (IN:[934..936] of) (NP (DT:[937..942] these) (VBN:[943..953] oxygenated) (NN:[954..966] arachidonate) (NNS:[967..978] metabolites)))) (VP (VBZ:[979..981] is) (VP (VBN:[982..992] stimulated) (NP-1 (-NONE-:[992..992] *)) (PP (IN:[994..996] by) (NP-LGS (NP (NN:[997..1005] arginine) (NN:[1006..1017] vasopressin)) (CC:[1018..1021] and) (NP (NN:[1022..1028] salmon) (NN:[1029..1039] calcitonin))))))))) (.:[1039..1040] .))) ;sentence 8 Span:1041..1212 ;In TALH cells obtained from rabbits made hypertensive by aortic constriction ;there was a selective increase in P1 and P2 formation compared to other ;renomedullary cells. (SENT (S (PP-LOC (IN:[1041..1043] In) (NP (NP (NN:[1044..1048] TALH) (NNS:[1049..1054] cells)) (VP (VBN:[1055..1063] obtained) (NP (-NONE-:[1063..1063] *)) (PP (IN:[1064..1068] from) (NP (NP (NNS:[1070..1077] rabbits)) (VP (VBN:[1078..1082] made) (NP (JJ:[1083..1095] hypertensive)) (PP-MNR (IN:[1096..1098] by) (NP (JJ:[1099..1105] aortic) (NN:[1106..1118] constriction))))))))) (NP-SBJ (EX:[1119..1124] there)) (VP (VBD:[1125..1128] was) (NP-PRD (NP (DT:[1129..1130] a) (JJ:[1131..1140] selective) (NN:[1141..1149] increase)) (PP (IN:[1151..1153] in) (NP (NP (NN:[1154..1156] P1) (NML-1 (-NONE-:[1156..1156] *P*))) (CC:[1157..1160] and) (NP (NN:[1161..1163] P2) (NML-1 (NN:[1164..1173] formation)))))) (S-ADV (NP-SBJ-2 (-NONE-:[1173..1173] *)) (VP (VBN:[1174..1182] compared) (NP-2 (-NONE-:[1182..1182] *)) (PP-CLR (TO:[1183..1185] to) (NP (JJ:[1186..1191] other) (JJ:[1192..1205] renomedullary) (NNS:[1206..1211] cells)))))) (.:[1211..1212] .))) ;section 9 Span:1216..1234 ;Publication Types: (SEC (NP (NNP:[1216..1227] Publication) (NNP:[1228..1233] Types) (::[1233..1234] :))) ;section 10 Span:1240..1246 ;Review (SEC (NP (NNP:[1240..1246] Review))) ;section 11 Span:1252..1268 ;Review, Tutorial (SEC (NP (NNP:[1252..1258] Review) (,:[1258..1259] ,) (NNP:[1260..1268] Tutorial))) ;section 12 Span:1272..1316 ;PMID: 2849519 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1272..1276] PMID) (::[1276..1277] :) (CD:[1278..1285] 2849519) (NN:[1286..1287] -LSB-) (NNP:[1287..1293] PubMed) (::[1294..1295] -) (NN:[1296..1303] indexed) (IN:[1304..1307] for) (NNP:[1308..1316] MEDLINE-RSB-)))