;PMID: 7157839 ;source_file_1860.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..35] = [t:0..35] ;1)sentence:[e:41..126] = [t:41..126] ;2)sentence:[e:127..171] = [t:127..171] ;3)section:[e:175..259] = [t:175..259] ;4)sentence:[e:263..503] = [t:263..503] ;5)sentence:[e:504..632] = [t:504..632] ;6)sentence:[e:633..763] = [t:633..763] ;7)sentence:[e:764..994] = [t:764..994] ;8)sentence:[e:995..1118] = [t:995..1118] ;9)sentence:[e:1119..1369] = [t:1119..1369] ;10)section:[e:1373..1417] = [t:1373..1417] ;section 0 Span:0..35 ;Xenobiotica. 1982 Sep;12(9):581-90. (SEC (FRAG (NNP:[0..11] Xenobiotica) (.:[11..12] .) (CD:[13..17] 1982) (CC:[18..25] Sep;12-LRB-) (CD:[25..26] 9) (-RRB-:[26..27] -RRB-) (::[27..28] :) (CD:[28..31] 581) (HYPH:[31..32] -) (CD:[32..34] 90) (.:[34..35] .))) ;sentence 1 Span:41..126 ;Studies on the metabolism of dimethylnitrosamine in vitro by rat-liver ;preparations. ;[70..89]:substance:"dimethylnitrosamine" (SENT (NP-HLN (NP (NNS:[41..48] Studies)) (PP (IN:[49..51] on) (NP (NP (DT:[52..55] the) (NN:[56..66] metabolism)) (PP (IN:[67..69] of) (NP (NN:[70..89] dimethylnitrosamine))) (ADJP (FW:[90..92] in) (FW:[93..98] vitro)) (PP (IN:[99..101] by) (NP (NML (NN:[102..105] rat) (HYPH:[105..106] -) (NN:[106..111] liver)) (NNS:[113..125] preparations))))) (.:[125..126] .))) ;sentence 2 Span:127..171 ;III. Effect of cobaltous chloride treatment. ;[142..160]:substance:"cobaltous chloride" (SENT (NP-HLN (LS:[127..131] III.)) (NP-HLN (NP (NN:[132..138] Effect)) (PP (IN:[139..141] of) (NP (NML (JJ:[142..151] cobaltous) (NN:[152..160] chloride)) (NN:[161..170] treatment))) (.:[170..171] .))) ;ERROR_Sentence has multiple children (TB Error):[127..171]::NP:NP: ;section 3 Span:175..259 ;Lake BG, Collins MA, Harris RA, Phillips JC, Cottrell RC, Longland RC, ;Gangolli SD. (SEC (FRAG (NNP:[175..179] Lake) (NNP:[180..182] BG) (,:[182..183] ,) (NNP:[184..191] Collins) (NNP:[192..194] MA) (,:[194..195] ,) (NNP:[196..202] Harris) (NNP:[203..205] RA) (,:[205..206] ,) (NNP:[207..215] Phillips) (NNP:[216..218] JC) (,:[218..219] ,) (NNP:[220..228] Cottrell) (NNP:[229..231] RC) (,:[231..232] ,) (NNP:[233..241] Longland) (NNP:[242..244] RC) (,:[244..245] ,) (NNP:[246..254] Gangolli) (NNP:[256..259] SD.))) ;sentence 4 Span:263..503 ;1. The effects of CoCl2 administration to rats on xenobiotic metabolism, ;dimethylnitrosamine (DMN) metabolism to formaldehyde and methanol, and ;monoamine oxidase (MAO) enzyme activities in hepatic subcellular fractions ;have been studied. ;[281..286]:substance:"CoCl2" ;[313..323]:substance:"xenobiotic" ;[337..356]:substance:"dimethylnitrosamine" ;[358..361]:substance:"DMN" ;[377..389]:substance:"formaldehyde" ;[394..402]:substance:"methanol" ;[408..439]:substance:"monoamine oxidase (MAO) enzyme" (SENT (NP (LS:[263..265] 1.)) (S (NP-SBJ-1 (NP (DT:[266..269] The) (NNS:[270..277] effects)) (PP (IN:[278..280] of) (NP (NP (NN:[281..286] CoCl2) (NN:[287..301] administration)) (NP (TO:[302..304] to) (NP (NNS:[305..309] rats))))) (PP (IN:[310..312] on) (NP (NP (JJ:[313..323] xenobiotic) (NN:[324..334] metabolism)) (,:[334..335] ,) (NP (NP (NML (NML (NN:[337..356] dimethylnitrosamine)) (NML (-LRB-:[357..358] -LRB-) (NN:[358..361] DMN) (-RRB-:[361..362] -RRB-))) (NN:[363..373] metabolism)) (PP (TO:[374..376] to) (NP (NN:[377..389] formaldehyde) (CC:[390..393] and) (NN:[394..402] methanol)))) (,:[402..403] ,) (CC:[404..407] and) (NP (NP (NML (NML (NN:[408..417] monoamine) (NN:[419..426] oxidase)) (NML (-LRB-:[427..428] -LRB-) (NN:[428..431] MAO) (-RRB-:[431..432] -RRB-))) (NN:[433..439] enzyme) (NNS:[440..450] activities)) (PP-LOC (IN:[451..453] in) (NP (JJ:[454..461] hepatic) (JJ:[462..473] subcellular) (NNS:[474..483] fractions))))))) (VP (VBP:[484..488] have) (VP (VBN:[489..493] been) (VP (VBN:[495..502] studied) (NP-1 (-NONE-:[502..502] *))))) (.:[502..503] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[263..503]::NP:S: ;sentence 5 Span:504..632 ;2. CoCl2 treatment markedly decreased hepatic mixed-function oxidase enzyme ;activities and microsomal cytochrome P-450 content. ;[507..512]:substance:"CoCl2" ;[550..580]:substance:"mixed-function oxidase enzyme" ;[607..623]:cyp450:"cytochrome P-450" (SENT (NP (LS:[504..506] 2.)) (S (NP-SBJ (NN:[507..512] CoCl2) (NN:[513..522] treatment)) (ADVP (RB:[523..531] markedly)) (VP (VBD:[532..541] decreased) (NP (NP (JJ:[542..549] hepatic) (NML (VBN:[550..555] mixed) (HYPH:[555..556] -) (NN:[556..564] function)) (NN:[565..572] oxidase) (NN:[574..580] enzyme) (NNS:[581..591] activities)) (CC:[592..595] and) (NP (JJ:[596..606] microsomal) (NML (NN:[607..617] cytochrome) (NN:[618..623] P-450)) (NN:[624..631] content)))) (.:[631..632] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[504..632]::NP:S: ;sentence 6 Span:633..763 ;In contrast, the N-oxidation of N, N-dimethylaniline and the activity of ;microsomal NADPH-cytochrome c reductase was unaffected. ;[666..686]:substance:"N, N-dimethylaniline" ;[719..747]:substance:"NADPH-cytochrome c reductase" (SENT (S (PP (IN:[633..635] In) (NP (NN:[636..644] contrast))) (,:[644..645] ,) (NP-SBJ (NP (NP (DT:[646..649] the) (NN:[651..662] N-oxidation)) (PP (IN:[663..665] of) (NP (NN:[666..667] N) (,:[667..668] ,) (NN:[669..686] N-dimethylaniline)))) (CC:[687..690] and) (NP (NP (DT:[691..694] the) (NN:[695..703] activity)) (PP (IN:[704..706] of) (NP (JJ:[707..717] microsomal) (NML (NN:[719..724] NADPH) (HYPH:[724..725] -) (NN:[725..735] cytochrome) (NN:[736..737] c)) (NN:[738..747] reductase))))) (VP (VBD:[748..751] was) (ADJP-PRD (JJ:[752..762] unaffected))) (.:[762..763] .))) ;sentence 7 Span:764..994 ;3. The metabolism of DMN to formaldehyde by postmitochondrial supernatant ;fractions was decreased at substrate concn. of 0 . 5, 5 and 50 mM by CoCl2 ;treatment but the metabolism of 5 and 50 mM DMN to methanol was affected ;less. ;[785..788]:substance:"DMN" ;[793..805]:substance:"formaldehyde" ;[827..838]:substance:"supernatant" ;[867..876]:substance:"substrate" ;[887..892]:quantitative-value:"0 . 5" ;[894..895]:quantitative-value:"5" ;[900..902]:quantitative-value:"50" ;[903..905]:quantitative-units:"mM" ;[909..914]:substance:"CoCl2" ;[948..949]:quantitative-value:"5" ;[954..956]:quantitative-value:"50" ;[957..959]:quantitative-units:"mM" ;[960..963]:substance:"DMN" ;[967..975]:substance:"methanol" (SENT (NP (LS:[764..766] 3.)) (S (S (NP-SBJ-4 (NP (DT:[767..770] The) (NN:[771..781] metabolism)) (PP (IN:[782..784] of) (NP (NN:[785..788] DMN))) (PP (TO:[789..791] to) (NP (NN:[793..805] formaldehyde))) (PP (IN:[806..808] by) (NP (JJ:[809..826] postmitochondrial) (JJ:[827..838] supernatant) (NNS:[839..848] fractions)))) (VP (VBD:[849..852] was) (VP (VBN:[853..862] decreased) (NP-4 (-NONE-:[862..862] *)) (PP (IN:[863..865] at) (NP (NP (NN:[867..876] substrate) (NN:[877..883] concn.)) (PP (IN:[884..886] of) (NP (NP (QP (CD:[887..888] 0) (.:[889..890] .) (CD:[891..892] 5)) (NML-3 (-NONE-:[892..892] *P*))) (,:[892..893] ,) (NP (CD:[894..895] 5) (NML-3 (-NONE-:[895..895] *P*))) (CC:[896..899] and) (NP (CD:[900..902] 50) (NML-3 (NN:[903..905] mM))))))) (PP (IN:[906..908] by) (NP (NN:[909..914] CoCl2) (NN:[915..924] treatment)))))) (CC:[925..928] but) (S (NP-SBJ-2 (NP (DT:[929..932] the) (NN:[933..943] metabolism)) (PP (IN:[944..946] of) (NP (NP (NML (CD:[948..949] 5) (NML-1 (-NONE-:[949..949] *P*))) (NML-5 (-NONE-:[949..949] *P*))) (CC:[950..953] and) (NP (NML (CD:[954..956] 50) (NML-1 (NN:[957..959] mM))) (NML-5 (NN:[960..963] DMN))))) (PP (TO:[964..966] to) (NP (NN:[967..975] methanol)))) (VP (VBD:[976..979] was) (VP (VBN:[980..988] affected) (NP-2 (-NONE-:[988..988] *)) (ADVP-EXT (RBR:[989..993] less))))) (.:[993..994] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[764..994]::NP:S: ;sentence 8 Span:995..1118 ;4. CoCl2 had little effect on MAO activities in whole homogenates, but ;microsomal MAO activities were markedly inhibited. ;[998..1003]:substance:"CoCl2" ;[1025..1028]:substance:"MAO" ;[1050..1061]:substance:"homogenates" ;[1078..1081]:substance:"MAO" (SENT (NP (LS:[995..997] 4.)) (S (S (NP-SBJ (NN:[998..1003] CoCl2)) (VP (VBD:[1004..1007] had) (NP (NP (JJ:[1008..1014] little) (NN:[1015..1021] effect)) (PP (IN:[1022..1024] on) (NP (NN:[1025..1028] MAO) (NNS:[1030..1040] activities)))) (PP-LOC (IN:[1041..1043] in) (NP (JJ:[1044..1049] whole) (NNS:[1050..1061] homogenates))))) (,:[1061..1062] ,) (CC:[1063..1066] but) (S (NP-SBJ-1 (JJ:[1067..1077] microsomal) (NN:[1078..1081] MAO) (NNS:[1082..1092] activities)) (VP (VBD:[1093..1097] were) (ADVP (RB:[1098..1106] markedly)) (VP (VBN:[1108..1117] inhibited) (NP-1 (-NONE-:[1117..1117] *))))) (.:[1117..1118] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[995..1118]::NP:S: ;sentence 9 Span:1119..1369 ;5. The inhibition of microsomal MAO indicates that CoCl2 is not a specific ;inhibitor of cytochrome P-450-dependent biotransformations and consequently ;the inhibition of DMN metabolism is not evidence of a wholly cytochrome ;P-450-dependent process. ;[1151..1154]:substance:"MAO" ;[1170..1175]:substance:"CoCl2" ;[1195..1204]:substance:"inhibitor" ;[1208..1224]:cyp450:"cytochrome P-450" ;[1290..1293]:substance:"DMN" ;[1334..1350]:cyp450:"cytochrome P-450" (SENT (NP (LS:[1119..1121] 5.)) (S (NP-SBJ (NP (DT:[1122..1125] The) (NN:[1126..1136] inhibition)) (PP (IN:[1137..1139] of) (NP (JJ:[1140..1150] microsomal) (NN:[1151..1154] MAO)))) (VP (VBZ:[1155..1164] indicates) (SBAR (IN:[1165..1169] that) (S (S (NP-SBJ (NN:[1170..1175] CoCl2)) (VP (VBZ:[1176..1178] is) (RB:[1179..1182] not) (NP-PRD (NP (DT:[1183..1184] a) (JJ:[1186..1194] specific) (NN:[1195..1204] inhibitor)) (PP (IN:[1205..1207] of) (NP (ADJP (NML (NN:[1208..1218] cytochrome) (NN:[1219..1224] P-450)) (HYPH:[1224..1225] -) (JJ:[1225..1234] dependent)) (NNS:[1235..1253] biotransformations)))))) (CC:[1254..1257] and) (S (ADVP (RB:[1259..1271] consequently)) (NP-SBJ (NP (DT:[1272..1275] the) (NN:[1276..1286] inhibition)) (PP (IN:[1287..1289] of) (NP (NN:[1290..1293] DMN) (NN:[1294..1304] metabolism)))) (VP (VBZ:[1305..1307] is) (RB:[1308..1311] not) (NP-PRD (NP (NN:[1312..1320] evidence)) (PP (IN:[1321..1323] of) (NP (DT:[1324..1325] a) (ADJP (RB:[1326..1332] wholly) (NML (NN:[1334..1344] cytochrome) (NN:[1345..1350] P-450)) (HYPH:[1350..1351] -) (JJ:[1351..1360] dependent)) (NN:[1361..1368] process))))))))) (.:[1368..1369] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[1119..1369]::NP:S: ;section 10 Span:1373..1417 ;PMID: 7157839 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1373..1377] PMID) (::[1377..1378] :) (CD:[1379..1386] 7157839) (NN:[1387..1388] -LSB-) (NNP:[1388..1394] PubMed) (::[1395..1396] -) (NN:[1397..1404] indexed) (IN:[1405..1408] for) (NNP:[1409..1417] MEDLINE-RSB-)))