;PMID: 2861116 ;source_file_1803.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..37] = [t:0..37] ;1)sentence:[e:43..96] = [t:43..96] ;2)section:[e:100..155] = [t:100..155] ;3)sentence:[e:159..471] = [t:159..471] ;4)sentence:[e:473..748] = [t:473..748] ;5)sentence:[e:749..999] = [t:749..999] ;6)sentence:[e:1000..1161] = [t:1000..1161] ;7)sentence:[e:1162..1394] = [t:1162..1394] ;8)section:[e:1398..1442] = [t:1398..1442] ;section 0 Span:0..37 ;Fertil Steril. 1985 Jul;44(1):125-32. (SEC (FRAG (NNP:[0..6] Fertil) (NNP:[7..13] Steril) (.:[13..14] .) (CD:[15..19] 1985) (::[20..27] Jul;44-LRB-) (CD:[27..28] 1) (-RRB-:[28..29] -RRB-) (::[29..30] :) (CD:[30..36] 125-32) (.:[36..37] .))) ;sentence 1 Span:43..96 ;Impaired testosterone biosynthesis in cryptorchidism. ;[52..64]:substance:"testosterone" (SENT (NP-HLN (NP (VBN:[43..51] Impaired) (NN:[52..64] testosterone) (NN:[65..77] biosynthesis)) (PP-LOC (IN:[78..80] in) (NP (NN:[81..95] cryptorchidism))) (.:[95..96] .))) ;section 2 Span:100..155 ;Farrer JH, Sikka SC, Xie HW, Constantinide D, Rajfer J. (SEC (FRAG (NNP:[100..106] Farrer) (NNP:[107..109] JH) (,:[109..110] ,) (NNP:[111..116] Sikka) (NNP:[117..119] SC) (,:[119..120] ,) (NNP:[121..124] Xie) (NNP:[125..127] HW) (,:[127..128] ,) (NNP:[129..142] Constantinide) (NNP:[143..144] D) (,:[144..145] ,) (NNP:[146..152] Rajfer) (NNP:[153..155] J.))) ;sentence 3 Span:159..471 ;In an attempt to determine whether the production and synthesis of ;testosterone (T) by the testis is impaired by the cryptorchid state, the ;ability of the cryptorchid rat testis to form T was assessed at various time ;periods into adulthood after the surgical induction of cryptorchidism in the ;newborn period. ;[226..238]:substance:"testosterone" ;[241..242]:substance:"T" ;[347..348]:substance:"T" (SENT (S (PP (IN:[159..161] In) (NP (DT:[162..164] an) (NN:[165..172] attempt) (S (NP-SBJ (-NONE-:[172..172] *)) (VP (TO:[173..175] to) (VP (VB:[176..185] determine) (SBAR (IN:[186..193] whether) (S (NP-SBJ-2 (NP (DT:[194..197] the) (NN:[198..208] production) (CC:[209..212] and) (NN:[213..222] synthesis)) (PP (IN:[223..225] of) (NP (NP (NN:[226..238] testosterone)) (NP (-LRB-:[240..241] -LRB-) (NN:[241..242] T) (-RRB-:[242..243] -RRB-)))) (PP (IN:[244..246] by) (NP (DT:[247..250] the) (NN:[251..257] testis)))) (VP (VBZ:[258..260] is) (VP (VBN:[261..269] impaired) (NP-2 (-NONE-:[269..269] *)) (PP (IN:[270..272] by) (NP-LGS (DT:[273..276] the) (NN:[277..288] cryptorchid) (NN:[289..294] state)))))))))))) (,:[294..295] ,) (NP-SBJ-1 (NP (DT:[296..299] the) (NN:[300..307] ability) (S-4 (-NONE-:[307..307] *ICH*))) (PP (IN:[308..310] of) (NP (DT:[311..314] the) (NN:[316..327] cryptorchid) (NN:[328..331] rat) (NN:[332..338] testis))) (S-4 (NP-SBJ (-NONE-:[338..338] *)) (VP (TO:[339..341] to) (VP (VB:[342..346] form) (NP (NN:[347..348] T)))))) (VP (VBD:[349..352] was) (VP (VBN:[353..361] assessed) (NP-1 (-NONE-:[361..361] *)) (PP-TMP (IN:[362..364] at) (NP (NP (JJ:[365..372] various) (NN:[373..377] time) (NNS:[378..385] periods)) (PP (IN:[386..390] into) (NP (NN:[392..401] adulthood))))) (PP (IN:[402..407] after) (NP (NP (NP (DT:[408..411] the) (JJ:[412..420] surgical) (NN:[421..430] induction)) (PP (IN:[431..433] of) (NP (NN:[434..448] cryptorchidism)))) (PP-TMP (IN:[449..451] in) (NP (DT:[452..455] the) (JJ:[456..463] newborn) (NN:[464..470] period))))))) (.:[470..471] .))) ;sentence 4 Span:473..748 ;The intratesticular T content of the descended testis rose from 0.3 ng/testis ;at 14 days of age to 71.2 ng/testis at adulthood (day 56); whereas in the ;cryptorchid testis, the values were 0.4 ng/testis and 2.0 ng/testis, ;respectively, at the same ages (P less than 0.001). ;[493..494]:substance:"T" ;[537..540]:quantitative-value:"0.3" ;[541..550]:quantitative-units:"ng/testis" ;[555..557]:quantitative-value:"14" ;[558..562]:quantitative-units:"days" ;[573..577]:quantitative-value:"71.2" ;[578..587]:quantitative-units:"ng/testis" ;[602..605]:quantitative-units:"day" ;[606..608]:quantitative-value:"56" ;[663..666]:quantitative-value:"0.4" ;[667..676]:quantitative-units:"ng/testis" ;[681..684]:quantitative-value:"2.0" ;[685..694]:quantitative-units:"ng/testis" (SENT (S (NP-SBJ (NP (DT:[473..476] The) (JJ:[477..492] intratesticular) (NN:[493..494] T) (NN:[495..502] content)) (PP (IN:[503..505] of) (NP (DT:[506..509] the) (VBN:[510..519] descended) (NN:[520..526] testis)))) (VP (VBD:[527..531] rose) (PP (PP (IN:[532..536] from) (NP (NP (NP (CD:[537..540] 0.3) (NN:[541..543] ng)) (PP (SYM:[543..544] /) (NP (NN:[544..550] testis)))) (PP-TMP (IN:[551..553] at) (NP (NP (CD:[555..557] 14) (NNS:[558..562] days)) (PP (IN:[563..565] of) (NP (NN:[566..569] age))))))) (PP (TO:[570..572] to) (NP (NP (NP (CD:[573..577] 71.2) (NN:[578..580] ng)) (PP (SYM:[580..581] /) (NP (NN:[581..587] testis)))) (PP-TMP (IN:[588..590] at) (NP (NP (NN:[591..600] adulthood)) (PRN (-LRB-:[601..602] -LRB-) (NP (NN:[602..605] day) (CD:[606..608] 56)) (-RRB-:[608..609] -RRB-))))))) (::[609..610] ;) (SBAR-ADV (IN:[611..618] whereas) (S (PP-LOC (IN:[619..621] in) (NP (DT:[622..625] the) (NN:[627..638] cryptorchid) (NN:[639..645] testis))) (,:[645..646] ,) (NP-SBJ (DT:[647..650] the) (NNS:[651..657] values)) (VP (VBD:[658..662] were) (NP-PRD (NP (NP (CD:[663..666] 0.4) (NN:[667..669] ng)) (PP (SYM:[669..670] /) (NP (NN:[670..676] testis)))) (CC:[677..680] and) (NP (NP (CD:[681..684] 2.0) (NN:[685..687] ng)) (PP (SYM:[687..688] /) (NP (NN:[688..694] testis)))) (,:[694..695] ,) (ADVP (RB:[697..709] respectively))) (,:[709..710] ,) (PP (IN:[711..713] at) (NP (DT:[714..717] the) (JJ:[718..722] same) (NNS:[723..727] ages))) (PRN (-LRB-:[728..729] -LRB-) (S (NP-SBJ (NN:[729..730] P)) (ADJP-PRD (JJR:[731..735] less) (PP (IN:[736..740] than) (NP (CD:[741..746] 0.001))))) (-RRB-:[746..747] -RRB-)))))) (.:[747..748] .))) ;sentence 5 Span:749..999 ;For determination of the site of inhibition of T biosynthesis in the ;cryptorchid testis, the enzymatic activities (17 alpha-hydroxylase, ;17,20-desmolase, and 17 beta-hydroxysteroid dehydrogenase) in the delta 4T ;biosynthetic pathway were measured. ;[797..798]:substance:"T" ;[866..886]:cyp450:"17 alpha-hydroxylase" ;[888..903]:cyp450:"17,20-desmolase" ;[909..946]:substance:"17 beta-hydroxysteroid dehydrogenase" (SENT (S (PP-PRP (IN:[749..752] For) (NP (NP (NN:[753..766] determination)) (PP (IN:[767..769] of) (NP (NP (DT:[770..773] the) (NN:[775..779] site)) (PP (IN:[780..782] of) (NP (NP (NN:[783..793] inhibition)) (PP (IN:[794..796] of) (NP (NN:[797..798] T) (NN:[799..811] biosynthesis))))) (PP-LOC (IN:[812..814] in) (NP (DT:[815..818] the) (NN:[819..830] cryptorchid) (NN:[831..837] testis))))))) (,:[837..838] ,) (NP-SBJ-1 (NP (DT:[839..842] the) (JJ:[843..852] enzymatic) (NNS:[854..864] activities)) (PRN (-LRB-:[865..866] -LRB-) (NP (NP (CD:[866..868] 17) (NN:[869..886] alpha-hydroxylase)) (,:[886..887] ,) (NP (NN:[888..903] 17,20-desmolase)) (,:[903..904] ,) (CC:[905..908] and) (NP (CD:[909..911] 17) (NN:[912..931] beta-hydroxysteroid) (NN:[933..946] dehydrogenase))) (-RRB-:[946..947] -RRB-)) (PP (IN:[948..950] in) (NP (DT:[951..954] the) (NML (SYM:[955..960] delta) (NN:[961..963] 4T)) (JJ:[964..976] biosynthetic) (NN:[977..984] pathway)))) (VP (VBD:[985..989] were) (VP (VBN:[990..998] measured) (NP-1 (-NONE-:[998..998] *)))) (.:[998..999] .))) ;sentence 6 Span:1000..1161 ;All these enzyme activities in the cryptorchid testis were inhibited at 56 ;days of age by about 80% when compared with the descended testis (P less ;than 0.01). ;[1011..1017]:substance:"enzyme" ;[1073..1075]:quantitative-value:"56" ;[1076..1080]:quantitative-units:"days" ;[1098..1101]:quantitative-value:"80%" (SENT (S (NP-SBJ-2 (NP (PDT:[1000..1003] All) (DT:[1004..1009] these) (NN:[1011..1017] enzyme) (NNS:[1018..1028] activities)) (PP-LOC (IN:[1029..1031] in) (NP (DT:[1032..1035] the) (NN:[1036..1047] cryptorchid) (NN:[1048..1054] testis)))) (VP (VBD:[1055..1059] were) (VP (VBN:[1060..1069] inhibited) (NP-2 (-NONE-:[1069..1069] *)) (PP-TMP (IN:[1070..1072] at) (NP (NP (CD:[1073..1075] 56) (NNS:[1076..1080] days)) (PP (IN:[1081..1083] of) (NP (NN:[1084..1087] age))))) (PP-EXT (IN:[1088..1090] by) (NP (QP (RB:[1092..1097] about) (CD:[1098..1100] 80)) (NN:[1100..1101] %))) (SBAR-ADV (WHADVP-1 (WRB:[1102..1106] when)) (S (NP-SBJ-3 (-NONE-:[1106..1106] *)) (VP (VBN:[1107..1115] compared) (NP-3 (-NONE-:[1115..1115] *)) (PP-CLR (IN:[1116..1120] with) (NP (DT:[1121..1124] the) (VBN:[1125..1134] descended) (NN:[1135..1141] testis))) (PRN (-LRB-:[1142..1143] -LRB-) (S (NP-SBJ (NN:[1143..1144] P)) (ADJP-PRD (JJR:[1145..1149] less) (PP (IN:[1150..1154] than) (NP (CD:[1155..1159] 0.01))))) (-RRB-:[1159..1160] -RRB-)) (ADVP-TMP-1 (-NONE-:[1160..1160] *T*))))))) (.:[1160..1161] .))) ;sentence 7 Span:1162..1394 ;These data suggest that cryptorchidism exerts a deleterious effect on the ;ability of the Leydig cells to synthesize T and may in part explain the ;abnormal morphology and resultant infertility seen in patients with ;cryptorchidism. ;[1280..1281]:substance:"T" (SENT (S (NP-SBJ (DT:[1162..1167] These) (NNS:[1168..1172] data)) (VP (VBP:[1174..1181] suggest) (SBAR (IN:[1182..1186] that) (S (NP-SBJ (NN:[1187..1201] cryptorchidism)) (VP (VP (VBZ:[1202..1208] exerts) (NP (DT:[1209..1210] a) (JJ:[1211..1222] deleterious) (NN:[1223..1229] effect)) (PP (IN:[1230..1232] on) (NP (NP (DT:[1233..1236] the) (NN:[1237..1244] ability) (S-1 (-NONE-:[1244..1244] *ICH*))) (PP (IN:[1245..1247] of) (NP (DT:[1248..1251] the) (NNP:[1253..1259] Leydig) (NNS:[1260..1265] cells))) (S-1 (NP-SBJ (-NONE-:[1265..1265] *)) (VP (TO:[1266..1268] to) (VP (VB:[1269..1279] synthesize) (NP (NN:[1280..1281] T)))))))) (CC:[1282..1285] and) (VP (MD:[1286..1289] may) (PP (IN:[1290..1292] in) (NP (NN:[1293..1297] part))) (VP (VB:[1298..1305] explain) (NP (NP (DT:[1306..1309] the) (NML (NML (JJ:[1310..1318] abnormal) (NN:[1319..1329] morphology)) (CC:[1330..1333] and) (NML (JJ:[1335..1344] resultant) (NN:[1345..1356] infertility)))) (VP (VBN:[1357..1361] seen) (NP (-NONE-:[1361..1361] *)) (PP-LOC (IN:[1362..1364] in) (NP (NP (NNS:[1365..1373] patients)) (PP (IN:[1374..1378] with) (NP (NN:[1379..1393] cryptorchidism))))))))))))) (.:[1393..1394] .))) ;section 8 Span:1398..1442 ;PMID: 2861116 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1398..1402] PMID) (::[1402..1403] :) (CD:[1404..1411] 2861116) (NN:[1412..1413] -LSB-) (NNP:[1413..1419] PubMed) (::[1420..1421] -) (NN:[1422..1429] indexed) (IN:[1430..1433] for) (NNP:[1434..1442] MEDLINE-RSB-)))