;PMID: 7297026 ;source_file_1798.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..43] = [t:0..43] ;1)sentence:[e:49..123] = [t:49..123] ;2)section:[e:127..152] = [t:127..152] ;3)sentence:[e:156..267] = [t:156..267] ;4)sentence:[e:268..492] = [t:268..492] ;5)sentence:[e:493..566] = [t:493..566] ;6)sentence:[e:567..871] = [t:567..871] ;7)sentence:[e:873..969] = [t:873..969] ;8)sentence:[e:970..1095] = [t:970..1095] ;9)sentence:[e:1096..1273] = [t:1096..1273] ;10)sentence:[e:1274..1379] = [t:1274..1379] ;11)section:[e:1383..1427] = [t:1383..1427] ;section 0 Span:0..43 ;Clin Pharmacol Ther. 1981 Nov;30(5):687-92. (SEC (FRAG (NNP:[0..4] Clin) (NNP:[5..14] Pharmacol) (NNP:[15..19] Ther) (.:[19..20] .) (CD:[21..25] 1981) (CD:[26..32] Nov;30) (-LRB-:[32..33] -LRB-) (CD:[33..34] 5) (-RRB-:[34..35] -RRB-) (CD:[35..39] :687) (::[39..40] -) (CD:[40..42] 92) (.:[42..43] .))) ;sentence 1 Span:49..123 ;Sensitivity of human placental monooxygenase activity to maternal smoking. ;[80..93]:substance:"monooxygenase" (SENT (NP-HLN (NP (NN:[49..60] Sensitivity)) (PP (IN:[61..63] of) (NP (JJ:[64..69] human) (JJ:[70..79] placental) (NN:[80..93] monooxygenase) (NN:[94..102] activity))) (PP (TO:[103..105] to) (NP (JJ:[106..114] maternal) (NN:[115..122] smoking))) (.:[122..123] .))) ;section 2 Span:127..152 ;Manchester DK, Jacoby EH. (SEC (FRAG (NNP:[127..137] Manchester) (NNP:[138..140] DK) (,:[140..141] ,) (NNP:[142..148] Jacoby) (NNP:[149..152] EH.))) ;sentence 3 Span:156..267 ;The in vitro oxidation of 7-ethoxyresorufin was studied in placental ;microsomes from 47 full-term pregnancies. ;[182..199]:substance:"7-ethoxyresorufin" (SENT (S (NP-SBJ-1 (NP (DT:[156..159] The) (ADJP (FW:[160..162] in) (FW:[163..168] vitro)) (NN:[169..178] oxidation)) (PP (IN:[179..181] of) (NP (NN:[182..199] 7-ethoxyresorufin)))) (VP (VBD:[200..203] was) (VP (VBN:[204..211] studied) (NP-1 (-NONE-:[211..211] *)) (PP-LOC (IN:[212..214] in) (NP (NP (JJ:[215..224] placental) (NNS:[225..235] microsomes)) (PP (IN:[237..241] from) (NP (CD:[242..244] 47) (NML (JJ:[245..249] full) (HYPH:[249..250] -) (NN:[250..254] term)) (NNS:[255..266] pregnancies))))))) (.:[266..267] .))) ;sentence 4 Span:268..492 ;Placental activities were compared in four groups formed on the basis of ;maternal smoking history as follows: nonsmokers (n = 12), passive smokers (n ;= 16), 1 to 20 cigarettes/day (n = 13), and 20+ cigarettes/day (n = 5). ;[427..434]:quantitative-value:"1 to 20" ;[435..449]:quantitative-units:"cigarettes/day" ;[464..467]:quantitative-value:"20+" ;[469..483]:quantitative-units:"cigarettes/day" (SENT (S (NP-SBJ-1 (JJ:[268..277] Placental) (NNS:[278..288] activities)) (VP (VBD:[289..293] were) (VP (VBN:[294..302] compared) (NP-1 (-NONE-:[302..302] *)) (PP (IN:[303..305] in) (NP (NP (CD:[306..310] four) (NNS:[311..317] groups)) (VP (VBN:[319..325] formed) (NP (-NONE-:[325..325] *)) (PP (IN:[326..328] on) (NP (NP (DT:[329..332] the) (NN:[333..338] basis)) (PP (IN:[339..341] of) (NP (JJ:[342..350] maternal) (NN:[351..358] smoking) (NN:[359..366] history))))) (PP (IN:[367..369] as) (S-NOM (NP-SBJ (-NONE-:[369..369] *)) (VP (VBZ:[370..377] follows) (::[377..378] :) (NP (NP (NNS:[379..389] nonsmokers) (PRN (-LRB-:[390..391] -LRB-) (S (NP-SBJ (NN:[391..392] n)) (VP (SYM:[393..394] =) (NP (CD:[395..397] 12)))) (-RRB-:[397..398] -RRB-))) (,:[398..399] ,) (NP (JJ:[401..408] passive) (NNS:[409..416] smokers) (PRN (-LRB-:[417..418] -LRB-) (S (NP-SBJ (NN:[418..419] n)) (VP (SYM:[420..421] =) (NP (CD:[422..424] 16)))) (-RRB-:[424..425] -RRB-))) (,:[425..426] ,) (NP (NP (QP (CD:[427..428] 1) (TO:[429..431] to) (CD:[432..434] 20)) (NNS:[435..445] cigarettes)) (PP (SYM:[445..446] /) (NP (NN:[446..449] day))) (PRN (-LRB-:[450..451] -LRB-) (S (NP-SBJ (NN:[451..452] n)) (VP (SYM:[453..454] =) (NP (CD:[455..457] 13)))) (-RRB-:[457..458] -RRB-))) (,:[458..459] ,) (CC:[460..463] and) (NP (NP (QP (CD:[464..466] 20) (SYM:[466..467] +)) (NNS:[469..479] cigarettes)) (PP (SYM:[479..480] /) (NP (NN:[480..483] day))) (PRN (-LRB-:[484..485] -LRB-) (S (NP-SBJ (NN:[485..486] n)) (VP (SYM:[487..488] =) (NP (CD:[489..490] 5)))) (-RRB-:[490..491] -RRB-)))))))))))) (.:[491..492] .))) ;sentence 5 Span:493..566 ;Passive smoking was defined as living with someone who smoke cigarettes. ;[555..565]:substance:"cigarettes" (SENT (S (NP-SBJ-2 (JJ:[493..500] Passive) (NN:[501..508] smoking)) (VP (VBD:[509..512] was) (VP (VBN:[513..520] defined) (NP-2 (-NONE-:[520..520] *)) (PP-CLR (IN:[521..523] as) (S-NOM (NP-SBJ (-NONE-:[523..523] *)) (VP (VBG:[524..530] living) (PP (IN:[531..535] with) (NP (NP (PRP:[536..543] someone)) (SBAR (WHNP-1 (WP:[544..547] who)) (S (NP-SBJ-1 (-NONE-:[547..547] *T*)) (VP (VBP:[549..554] smoke) (NP (NNS:[555..565] cigarettes)))))))))))) (.:[565..566] .))) ;sentence 6 Span:567..871 ;Umbilical cord plasma thiocyanate concentrations were measured to confirm ;histories and were higher when mothers smoked (80 +/- 10 micro M, 1 to 20 ;cigarettes/day, 116 +/- 8 micro M, 20+ cigarettes/day) than when mothers did ;not smoke (34 +/- 3 micro M, nonsmokers; 35 +/- 3 micro M, passive smokers). ;[589..600]:substance:"thiocyanate" ;[689..698]:quantitative-value:"80 +/- 10" ;[699..706]:quantitative-units:"micro M" ;[708..716]:quantitative-value:"1 to 20" ;[717..731]:quantitative-units:"cigarettes/day" ;[733..742]:quantitative-value:"116 +/- 8" ;[743..750]:quantitative-units:"micro M" ;[752..755]:quantitative-value:"20+" ;[756..770]:quantitative-units:"cigarettes/day" ;[806..814]:quantitative-value:"34 +/- 3" ;[815..822]:quantitative-units:"micro M" ;[836..844]:quantitative-value:"35 +/- 3" ;[845..852]:quantitative-units:"micro M" (SENT (S (NP-SBJ-2 (NML (NML (JJ:[567..576] Umbilical) (NN:[577..581] cord)) (NN:[582..588] plasma)) (NN:[589..600] thiocyanate) (NNS:[601..615] concentrations)) (VP (VP (VBD:[616..620] were) (VP (VBN:[621..629] measured) (NP-2 (-NONE-:[629..629] *)) (S-PRP (NP-SBJ (-NONE-:[629..629] *)) (VP (TO:[631..633] to) (VP (VB:[634..641] confirm) (NP (NNS:[642..651] histories))))))) (CC:[652..655] and) (VP (VBD:[656..660] were) (ADJP-PRD (ADJP (JJR:[661..667] higher)) (PP-4 (-NONE-:[667..667] *ICH*))) (SBAR-ADV (WHADVP-3 (WRB:[668..672] when)) (S (NP-SBJ (NNS:[673..680] mothers)) (VP (VBD:[681..687] smoked) (ADVP-3 (-NONE-:[687..687] *T*)) (PRN (-LRB-:[688..689] -LRB-) (FRAG (NP (QP (CD:[689..691] 80) (SYM:[692..695] +/-) (CD:[696..698] 10)) (NN:[699..704] micro) (NN:[705..706] M)) (,:[706..707] ,) (NP (NP (QP (CD:[708..709] 1) (TO:[711..713] to) (CD:[714..716] 20)) (NNS:[717..727] cigarettes)) (PP (SYM:[727..728] /) (NP (NN:[728..731] day))))) (,:[731..732] ,) (FRAG (NP (QP (CD:[733..736] 116) (SYM:[737..740] +/-) (CD:[741..742] 8)) (NN:[743..748] micro) (NN:[749..750] M)) (,:[750..751] ,) (NP (NP (QP (CD:[752..754] 20) (SYM:[754..755] +)) (NNS:[756..766] cigarettes)) (PP (SYM:[766..767] /) (NP (NN:[767..770] day))))) (-RRB-:[770..771] -RRB-))))) (PP-4 (IN:[772..776] than) (SBAR (WHADVP-1 (WRB:[777..781] when)) (S (NP-SBJ (NNS:[782..789] mothers)) (VP (VBD:[791..794] did) (RB:[795..798] not) (VP (VB:[799..804] smoke) (ADVP-1 (-NONE-:[804..804] *T*)) (PRN (-LRB-:[805..806] -LRB-) (FRAG (NP (QP (CD:[806..808] 34) (SYM:[809..812] +/-) (CD:[813..814] 3)) (NN:[815..820] micro) (NN:[821..822] M)) (,:[822..823] ,) (NP (NNS:[824..834] nonsmokers))) (::[834..835] ;) (FRAG (NP (QP (CD:[836..838] 35) (SYM:[839..842] +/-) (CD:[843..844] 3)) (NN:[845..850] micro) (NN:[851..852] M)) (,:[852..853] ,) (NP (JJ:[854..861] passive) (NNS:[862..869] smokers))) (-RRB-:[869..870] -RRB-))))))))) (.:[870..871] .))) ;sentence 7 Span:873..969 ;7-Ethoxyresorufin O-deethylase activity was increased 10- to 30-fold in ;placentas from smokers. ;[873..903]:cyp450:"7-Ethoxyresorufin O-deethylase" ;[927..941]:quantitative-value:"10- to 30-fold" (SENT (S (NP-SBJ-1 (NML (NN:[873..890] 7-Ethoxyresorufin) (NN:[891..903] O-deethylase)) (NN:[904..912] activity)) (VP (VBD:[913..916] was) (VP (VBN:[917..926] increased) (NP-1 (-NONE-:[926..926] *)) (ADVP-EXT (QP (CD:[927..929] 10) (HYPH:[929..930] -) (TO:[931..933] to) (CD:[934..936] 30)) (HYPH:[936..937] -) (RB:[937..941] fold)) (PP-LOC (IN:[942..944] in) (NP (NP (NNS:[946..955] placentas)) (PP (IN:[956..960] from) (NP (NNS:[961..968] smokers))))))) (.:[968..969] .))) ;sentence 8 Span:970..1095 ;Activity toward 7-ethoxyresorufin in placentas from smokers was markedly ;inhibited in vitro by addition of 7,8-benzoflavone. ;[986..1003]:substance:"7-ethoxyresorufin" ;[1078..1094]:substance:"7,8-benzoflavone" (SENT (S (NP-SBJ-1 (NP (NN:[970..978] Activity)) (PP (IN:[979..985] toward) (NP (NN:[986..1003] 7-ethoxyresorufin))) (PP-LOC (IN:[1004..1006] in) (NP (NP (NNS:[1007..1016] placentas)) (PP (IN:[1017..1021] from) (NP (NNS:[1023..1030] smokers)))))) (VP (VBD:[1031..1034] was) (ADVP (RB:[1035..1043] markedly)) (VP (VBN:[1044..1053] inhibited) (NP-1 (-NONE-:[1053..1053] *)) (ADVP (FW:[1054..1056] in) (FW:[1057..1062] vitro)) (PP (IN:[1063..1065] by) (NP-LGS (NP (NN:[1066..1074] addition)) (PP (IN:[1075..1077] of) (NP (NN:[1078..1094] 7,8-benzoflavone))))))) (.:[1094..1095] .))) ;sentence 9 Span:1096..1273 ;Among nonsmokers, percent inhibition of O-deethylase activity by ;7,8-benzoflavone was greater (P less than 0.05) in placentas from women ;passively exposed to cigarette smoke. ;[1137..1149]:substance:"O-deethylase" ;[1162..1178]:substance:"7,8-benzoflavone" ;[1257..1272]:substance:"cigarette smoke" (SENT (S (PP (IN:[1096..1101] Among) (NP (NNS:[1103..1113] nonsmokers))) (,:[1113..1114] ,) (NP-SBJ (NP (NN:[1115..1122] percent) (NN:[1123..1133] inhibition)) (PP (IN:[1134..1136] of) (NP (NN:[1137..1149] O-deethylase) (NN:[1150..1158] activity))) (PP (IN:[1159..1161] by) (NP (NN:[1162..1178] 7,8-benzoflavone)))) (VP (VBD:[1179..1182] was) (ADJP-PRD (JJR:[1184..1191] greater) (PRN (-LRB-:[1192..1193] -LRB-) (S (NP-SBJ (NN:[1193..1194] P)) (ADJP-PRD (ADJP (JJR:[1195..1199] less)) (PP (IN:[1200..1204] than) (NP (CD:[1205..1209] 0.05))))) (-RRB-:[1209..1210] -RRB-))) (PP-LOC (IN:[1211..1213] in) (NP (NP (NNS:[1214..1223] placentas)) (PP (IN:[1224..1228] from) (NP (NP (NNS:[1229..1234] women)) (VP (ADVP (RB:[1235..1244] passively)) (VBN:[1245..1252] exposed) (NP (-NONE-:[1252..1252] *)) (PP (TO:[1253..1255] to) (NP (NN:[1257..1266] cigarette) (NN:[1267..1272] smoke))))))))) (.:[1272..1273] .))) ;sentence 10 Span:1274..1379 ;Human placental monooxygenase activity is sensitive to both active and ;passive cigarette smoke exposure. ;[1290..1303]:substance:"monooxygenase" ;[1354..1369]:substance:"cigarette smoke" (SENT (S (NP-SBJ (JJ:[1274..1279] Human) (JJ:[1280..1289] placental) (NN:[1290..1303] monooxygenase) (NN:[1304..1312] activity)) (VP (VBZ:[1313..1315] is) (ADJP-PRD (JJ:[1316..1325] sensitive) (PP (TO:[1326..1328] to) (NP (CC:[1329..1333] both) (NML (NML (JJ:[1335..1341] active) (NML-1 (-NONE-:[1341..1341] *P*))) (CC:[1342..1345] and) (NML (JJ:[1346..1353] passive) (NML-1 (NML (NN:[1354..1363] cigarette) (NN:[1364..1369] smoke)) (NN:[1370..1378] exposure)))))))) (.:[1378..1379] .))) ;section 11 Span:1383..1427 ;PMID: 7297026 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[1383..1387] PMID) (::[1387..1388] :) (CD:[1389..1396] 7297026) (NN:[1397..1398] -LSB-) (NNP:[1398..1404] PubMed) (::[1405..1406] -) (NN:[1407..1414] indexed) (IN:[1415..1418] for) (NNP:[1419..1427] MEDLINE-RSB-)))