;PMID: 8137936 ;source_file_1793.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..39] = [t:0..39] ;1)sentence:[e:45..167] = [t:45..167] ;2)section:[e:171..192] = [t:171..192] ;3)section:[e:196..285] = [t:196..285] ;4)sentence:[e:289..499] = [t:289..499] ;5)sentence:[e:500..663] = [t:500..663] ;6)sentence:[e:664..782] = [t:664..782] ;7)sentence:[e:783..904] = [t:783..904] ;8)section:[e:908..952] = [t:908..952] ;section 0 Span:0..39 ;FEBS Lett. 1994 Mar 21;341(2-3):177-81. (SEC (FRAG (NNP:[0..4] FEBS) (NNP:[5..9] Lett) (.:[9..10] .) (CD:[11..15] 1994) (NNP:[16..19] Mar) (CC:[20..27] 21;341-LRB-) (NN:[27..30] 2-3) (-RRB-:[30..31] -RRB-) (CD:[31..35] :177) (::[35..36] -) (CD:[36..38] 81) (.:[38..39] .))) ;sentence 1 Span:45..167 ;Induction of aromatase in stromal vascular cells from human breast adipose ;tissue depends on cortisol and growth factors. ;[58..67]:cyp450:"aromatase" ;[139..147]:substance:"cortisol" ;[152..166]:substance:"growth factors" (SENT (S-HLN (NP-SBJ (NP (NN:[45..54] Induction)) (PP (IN:[55..57] of) (NP (NN:[58..67] aromatase))) (PP-LOC (IN:[68..70] in) (NP (NP (JJ:[71..78] stromal) (JJ:[79..87] vascular) (NNS:[88..93] cells)) (PP (IN:[94..98] from) (NP (JJ:[99..104] human) (NN:[105..111] breast) (NN:[112..119] adipose) (NN:[121..127] tissue)))))) (VP (VBZ:[128..135] depends) (PP-CLR (IN:[136..138] on) (NP (NP (NN:[139..147] cortisol)) (CC:[148..151] and) (NP (NN:[152..158] growth) (NNS:[159..166] factors))))) (.:[166..167] .))) ;section 2 Span:171..192 ;Schmidt M, Loffler G. (SEC (FRAG (NNP:[171..178] Schmidt) (NNP:[179..181] M,) (NNP:[182..189] Loffler) (NNP:[190..192] G.))) ;section 3 Span:196..285 ;Institute of Biochemistry, Genetics and Microbiology, University of ;Regensburg, Germany. (SEC (FRAG (NNP:[196..205] Institute) (IN:[206..208] of) (NNP:[209..221] Biochemistry) (,:[221..222] ,) (NNP:[223..231] Genetics) (CC:[232..235] and) (NNP:[236..248] Microbiology) (,:[248..249] ,) (NNP:[250..260] University) (IN:[261..263] of) (NNP:[264..274] Regensburg) (,:[274..275] ,) (NNP:[277..284] Germany) (.:[284..285] .))) ;sentence 4 Span:289..499 ;The regulation of aromatase (estrogen synthase) activity of cultured stromal ;vascular cells from human breast adipose tissue by cortisol, db-cAMP and ;growth factors was studied in a serum-free culture system. ;[307..316]:cyp450:"aromatase" ;[318..335]:cyp450:"estrogen synthase" ;[418..426]:substance:"cortisol" ;[428..435]:substance:"db-cAMP" ;[440..455]:substance:"growth factors" (SENT (S (NP-SBJ-1 (NP (DT:[289..292] The) (NN:[293..303] regulation)) (PP (IN:[304..306] of) (NP (NP (NML (NML (NN:[307..316] aromatase)) (NML (-LRB-:[317..318] -LRB-) (NN:[318..326] estrogen) (NN:[327..335] synthase) (-RRB-:[335..336] -RRB-))) (NN:[337..345] activity)) (PP (IN:[346..348] of) (NP (NP (VBN:[349..357] cultured) (JJ:[358..365] stromal) (JJ:[367..375] vascular) (NNS:[376..381] cells)) (PP (IN:[382..386] from) (NP (JJ:[387..392] human) (NN:[393..399] breast) (NN:[400..407] adipose) (NN:[408..414] tissue))))))) (PP (IN:[415..417] by) (NP (NP (NN:[418..426] cortisol)) (,:[426..427] ,) (NP (NN:[428..435] db-cAMP)) (CC:[436..439] and) (NP (NN:[440..446] growth) (NNS:[448..455] factors))))) (VP (VBD:[456..459] was) (VP (VBN:[460..467] studied) (NP-1 (-NONE-:[467..467] *)) (PP-LOC (IN:[468..470] in) (NP (DT:[471..472] a) (ADJP (NN:[473..478] serum) (HYPH:[478..479] -) (JJ:[479..483] free)) (NN:[484..491] culture) (NN:[492..498] system))))) (.:[498..499] .))) ;sentence 5 Span:500..663 ;While PDGF-BB alone inhibited the effect of db-cAMP on aromatase induction, ;it stimulated aromatase activity in the presence of cortisol with or without ;db-cAMP. ;[506..513]:substance:"PDGF-BB" ;[545..552]:substance:"db-cAMP" ;[556..565]:cyp450:"aromatase" ;[591..600]:cyp450:"aromatase" ;[630..638]:substance:"cortisol" ;[655..662]:substance:"db-cAMP" (SENT (S (SBAR (IN:[500..505] While) (S (NP-SBJ (NN:[506..513] PDGF-BB) (ADJP (RB:[514..519] alone))) (VP (VBD:[521..530] inhibited) (NP (NP (DT:[531..534] the) (NN:[535..541] effect)) (PP (IN:[542..544] of) (NP (NN:[545..552] db-cAMP))) (PP (IN:[553..555] on) (NP (NN:[556..565] aromatase) (NN:[566..575] induction))))))) (,:[575..576] ,) (NP-SBJ (PRP:[577..579] it)) (VP (VBD:[580..590] stimulated) (NP (NN:[591..600] aromatase) (NN:[602..610] activity)) (PP-LOC (IN:[611..613] in) (NP (NP (DT:[614..617] the) (NN:[618..626] presence)) (PP (IN:[627..629] of) (NP (NN:[630..638] cortisol))))) (PP (IN:[639..643] with) (CC:[644..646] or) (IN:[647..654] without) (NP (NN:[655..662] db-cAMP)))) (.:[662..663] .))) ;sentence 6 Span:664..782 ;In the presence of 1 microM insulin consistently higher aromatase activities ;were found as compared to 1 nM insulin. ;[684..685]:quantitative-value:"1" ;[686..692]:quantitative-units:"microM" ;[693..700]:substance:"insulin" ;[721..730]:cyp450:"aromatase" ;[769..770]:quantitative-value:"1" ;[771..773]:quantitative-units:"nM" ;[774..781]:substance:"insulin" (SENT (S (PP-LOC (IN:[664..666] In) (NP (NP (DT:[667..670] the) (NN:[671..679] presence)) (PP (IN:[680..682] of) (NP (NML (CD:[684..685] 1) (NN:[686..692] microM)) (NN:[693..700] insulin))))) (NP-SBJ-1 (ADJP (RB:[701..713] consistently) (JJR:[714..720] higher)) (NN:[721..730] aromatase) (NNS:[731..741] activities)) (VP (VBD:[742..746] were) (VP (VBN:[747..752] found) (NP-1 (-NONE-:[752..752] *)) (PP (IN:[753..755] as) (S-NOM (NP-SBJ (-NONE-:[755..755] *)) (VP (VBN:[756..764] compared) (PP-CLR (TO:[766..768] to) (NP (NML (CD:[769..770] 1) (NN:[771..773] nM)) (NN:[774..781] insulin)))))))) (.:[781..782] .))) ;sentence 7 Span:783..904 ;In contrast to PDGF-BB, bFGF led to an increase of aromatase activity only ;in the presence of both cortisol and db-cAMP. ;[798..805]:substance:"PDGF-BB" ;[807..811]:substance:"bFGF" ;[834..843]:cyp450:"aromatase" ;[883..891]:substance:"cortisol" ;[896..903]:substance:"db-cAMP" (SENT (S (PP (IN:[783..785] In) (NP (NP (NN:[786..794] contrast)) (PP (TO:[795..797] to) (NP (NN:[798..805] PDGF-BB))))) (,:[805..806] ,) (NP-SBJ (NN:[807..811] bFGF)) (VP (VBD:[812..815] led) (PP-CLR (TO:[816..818] to) (NP (NP (DT:[819..821] an) (NN:[822..830] increase)) (PP (IN:[831..833] of) (NP (NN:[834..843] aromatase) (NN:[845..853] activity))))) (PP-LOC (RB:[854..858] only) (IN:[859..861] in) (NP (NP (DT:[862..865] the) (NN:[866..874] presence)) (PP (IN:[875..877] of) (NP (CC:[878..882] both) (NN:[883..891] cortisol) (CC:[892..895] and) (NN:[896..903] db-cAMP)))))) (.:[903..904] .))) ;section 8 Span:908..952 ;PMID: 8137936 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[908..912] PMID) (::[912..913] :) (CD:[914..921] 8137936) (NN:[922..923] -LSB-) (NNP:[923..929] PubMed) (::[930..931] -) (NN:[932..939] indexed) (IN:[940..943] for) (NNP:[944..952] MEDLINE-RSB-)))