;PMID: 3365254 ;source_file_1019.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..53] = [t:0..53] ;1)sentence:[e:59..186] = [t:59..186] ;2)section:[e:190..239] = [t:190..239] ;3)section:[e:243..310] = [t:243..310] ;4)sentence:[e:314..650] = [t:314..650] ;5)sentence:[e:651..854] = [t:651..854] ;6)sentence:[e:855..1012] = [t:855..1012] ;7)sentence:[e:1013..1251] = [t:1013..1251] ;8)section:[e:1255..1299] = [t:1255..1298] ;Sentence Matching Errors ;ERROR_Section end mismatch[e:1255..1299][t:1255..1298] ;Token/POS Errors ;ERROR_Token in entity file but not tree[1298..1299] ] ;section 0 Span:0..53 ;Biochem Biophys Res Commun. 1988 Apr 29;152(2):843-8. (SEC (FRAG (NNP:[0..7] Biochem) (NNP:[8..15] Biophys) (NNP:[16..19] Res) (NNP:[20..26] Commun) (.:[26..27] .) (CD:[28..32] 1988) (NNP:[33..36] Apr) (CD:[37..44] 29;152-LRB-) (CD:[44..45] 2) (-RRB-:[45..46] -RRB-) (CD:[46..50] :843) (::[50..51] -) (CD:[51..53] 8.))) ;sentence 1 Span:59..186 ;A male-specific renal cytochrome P-450 isozyme(s) responsible for mutagenic ;activation of 3-methoxy-4-aminoazobenzene in mice. ;[81..108]:cyp450:"cytochrome P-450 isozyme(s)" ;[150..177]:substance:"3-methoxy-4-aminoazobenzene" (SENT (NP-HLN (NP (DT:[59..60] A) (ADJP (NN:[61..65] male) (HYPH:[65..66] -) (JJ:[66..74] specific)) (JJ:[75..80] renal) (NML (NN:[81..91] cytochrome) (NN:[92..97] P-450)) (NN:[98..108] isozyme-LRB-s-RRB-)) (ADJP (JJ:[109..120] responsible) (PP (IN:[121..124] for) (NP (NP (JJ:[125..134] mutagenic) (NN:[136..146] activation)) (PP (IN:[147..149] of) (NP (NN:[150..177] 3-methoxy-4-aminoazobenzene))) (PP-LOC (IN:[178..180] in) (NP (NNS:[181..185] mice)))))) (.:[185..186] .))) ;section 2 Span:190..239 ;Degawa M, Namiki M, Miura S, Ueno H, Hashimoto Y. (SEC (FRAG (NNP:[190..196] Degawa) (NNP:[197..199] M,) (NNP:[200..206] Namiki) (NNP:[207..209] M,) (NNP:[210..215] Miura) (NNP:[216..218] S,) (NNP:[219..223] Ueno) (NNP:[224..225] H) (,:[225..226] ,) (NNP:[227..236] Hashimoto) (NNP:[237..239] Y.))) ;section 3 Span:243..310 ;Department of Hygienic Chemistry, Tohoku University, Sendai, Japan. (SEC (FRAG (NNP:[243..253] Department) (IN:[254..256] of) (NNP:[257..265] Hygienic) (NNP:[266..275] Chemistry) (,:[275..276] ,) (NNP:[277..283] Tohoku) (NNP:[284..294] University) (,:[294..295] ,) (NNP:[296..302] Sendai) (,:[302..303] ,) (NNP:[304..309] Japan) (.:[309..310] .))) ;sentence 4 Span:314..650 ;Renal microsomes from male mice (BALB/c, DBA/2 and BALB/c x DBA/2 F1) showed ;about 10-fold greater activity for mediating mutagenic activation of ;3-methoxy-4-aminoazobenzene (3-MeO-AAB) toward Salmonella typhimurium TA98 ;than did the corresponding hepatic microsomes, as compared on the basis of ;nmol of microsomal cytochrome P-450. ;[398..405]:quantitative-value:"10-fold" ;[462..489]:substance:"3-methoxy-4-aminoazobenzene" ;[491..500]:substance:"3-MeO-AAB" ;[613..617]:quantitative-units:"nmol" ;[633..649]:cyp450:"cytochrome P-450" (SENT (S (NP-SBJ (NP (JJ:[314..319] Renal) (NNS:[320..330] microsomes)) (PP (IN:[331..335] from) (NP (JJ:[336..340] male) (NNS:[341..345] mice))) (PRN (-LRB-:[346..347] -LRB-) (NP (NP (NN:[347..353] BALB/c)) (,:[353..354] ,) (NP (NN:[355..360] DBA/2)) (CC:[361..364] and) (NP (NN:[365..371] BALB/c) (SYM:[372..373] x) (NN:[374..379] DBA/2) (NN:[380..382] F1))) (-RRB-:[382..383] -RRB-))) (VP (VBD:[384..390] showed) (NP (NP (ADJP (QP (IN:[392..397] about) (CD:[398..400] 10) (HYPH:[400..401] -) (RB:[401..405] fold)) (JJR:[406..413] greater)) (NN:[414..422] activity)) (PP (IN:[423..426] for) (S-NOM (NP-SBJ (-NONE-:[426..426] *)) (VP (VBG:[427..436] mediating) (NP (NP (JJ:[437..446] mutagenic) (NN:[447..457] activation)) (PP (IN:[458..460] of) (NP (NP (NN:[462..489] 3-methoxy-4-aminoazobenzene)) (NP (-LRB-:[490..491] -LRB-) (NN:[491..500] 3-MeO-AAB) (-RRB-:[500..501] -RRB-))))) (PP (IN:[502..508] toward) (NP (NNP:[509..519] Salmonella) (NNP:[520..531] typhimurium) (NN:[532..536] TA98)))))) (SBAR (IN:[537..541] than) (SINV (VBD:[543..546] did) (NP-SBJ (DT:[547..550] the) (JJ:[551..564] corresponding) (JJ:[565..572] hepatic) (NNS:[573..583] microsomes)) (VP (-NONE-:[583..583] *?*))))) (,:[583..584] ,) (SBAR-ADV (IN:[585..587] as) (S (NP-SBJ-1 (-NONE-:[587..587] *)) (VP (VBN:[588..596] compared) (NP-1 (-NONE-:[596..596] *)) (PP (IN:[597..599] on) (NP (NP (DT:[600..603] the) (NN:[604..609] basis)) (PP (IN:[610..612] of) (NP (NP (NN:[613..617] nmol)) (PP (IN:[618..620] of) (NP (JJ:[622..632] microsomal) (NN:[633..643] cytochrome) (NN:[644..649] P-450))))))))))) (.:[649..650] .))) ;sentence 5 Span:651..854 ;On the other hand, female renal microsomes and other extrahepatic microsomes ;(lung, small intestine and colon) in both sexes of mice showed little or no ;activity for converting 3-MeO-AAB to mutagen(s). ;[830..839]:substance:"3-MeO-AAB" ;[843..853]:substance:"mutagen(s)" (SENT (S (PP (IN:[651..653] On) (NP (DT:[654..657] the) (JJ:[658..663] other) (NN:[664..668] hand))) (,:[668..669] ,) (NP-SBJ (NP (NP (JJ:[670..676] female) (JJ:[677..682] renal) (NNS:[683..693] microsomes)) (CC:[694..697] and) (NP (JJ:[699..704] other) (JJ:[705..717] extrahepatic) (NNS:[718..728] microsomes) (PRN (-LRB-:[729..730] -LRB-) (NP (NP (NN:[730..734] lung)) (,:[734..735] ,) (NP (JJ:[736..741] small) (NN:[742..751] intestine)) (CC:[752..755] and) (NP (NN:[756..761] colon))) (-RRB-:[761..762] -RRB-)))) (PP-LOC (IN:[763..765] in) (NP (NP (DT:[766..770] both) (NNS:[771..776] sexes)) (PP (IN:[777..779] of) (NP (NNS:[781..785] mice)))))) (VP (VBD:[786..792] showed) (NP (NP (NP (JJ:[793..799] little) (NML-1 (-NONE-:[799..799] *P*))) (CC:[800..802] or) (NP (DT:[803..805] no) (NML-1 (NN:[806..814] activity)))) (PP (IN:[815..818] for) (S-NOM (NP-SBJ (-NONE-:[818..818] *)) (VP (VBG:[819..829] converting) (NP (NN:[830..839] 3-MeO-AAB)) (PP (TO:[840..842] to) (NP (NNS:[843..853] mutagen-LRB-s-RRB-)))))))) (.:[853..854] .))) ;sentence 6 Span:855..1012 ;The mutagenic activation of 3-MeO-AAB with the male renal enzyme(s) was ;definitely inhibited by cytochrome P-450 inhibitors, 7,8-benzoflavone and ;SKF 525A. ;[884..893]:substance:"3-MeO-AAB" ;[914..923]:cyp450:"enzyme(s)" ;[953..969]:cyp450:"cytochrome P-450" ;[970..980]:substance:"inhibitors" ;[982..998]:substance:"7,8-benzoflavone" ;[1003..1011]:substance:"SKF 525A" (SENT (S (NP-SBJ-1 (NP (DT:[855..858] The) (JJ:[860..869] mutagenic) (NN:[870..880] activation)) (PP (IN:[881..883] of) (NP (NN:[884..893] 3-MeO-AAB))) (PP (IN:[894..898] with) (NP (DT:[899..902] the) (JJ:[903..907] male) (JJ:[908..913] renal) (NN:[914..923] enzyme-LRB-s-RRB-)))) (VP (VBD:[924..927] was) (ADVP (RB:[928..938] definitely)) (VP (VBN:[940..949] inhibited) (NP-1 (-NONE-:[949..949] *)) (PP (IN:[950..952] by) (NP-LGS (NP (NML (NN:[953..963] cytochrome) (NN:[964..969] P-450)) (NNS:[970..980] inhibitors)) (IN:[980..981] ,) (NP (NP (NN:[982..998] 7,8-benzoflavone)) (CC:[999..1002] and) (NP (NN:[1003..1006] SKF) (NN:[1007..1011] 525A))))))) (.:[1011..1012] .))) ;sentence 7 Span:1013..1251 ;All these findings suggest that in mice, there is a male-specific renal ;3-MeO-AAB activation enzyme(s), a cytochrome P-450 isozyme(s), which is ;different, at least in proportion and/or in nature, from hepatic cytochrome ;P-450 isozymes. ;[1086..1095]:substance:"3-MeO-AAB" ;[1108..1117]:cyp450:"enzyme(s)" ;[1121..1148]:cyp450:"cytochrome P-450 isozyme(s)" ;[1225..1250]:cyp450:"cytochrome P-450 isozymes" (SENT (S (NP-SBJ (PDT:[1013..1016] All) (DT:[1018..1023] these) (NNS:[1024..1032] findings)) (VP (VBP:[1033..1040] suggest) (SBAR (IN:[1041..1045] that) (S (PP-LOC (IN:[1046..1048] in) (NP (NNS:[1049..1053] mice))) (,:[1053..1054] ,) (NP-SBJ (EX:[1055..1060] there)) (VP (VBZ:[1061..1063] is) (NP-PRD (NP (NP (DT:[1064..1065] a) (ADJP (NN:[1066..1070] male) (HYPH:[1070..1071] -) (JJ:[1071..1079] specific)) (JJ:[1080..1085] renal) (NML (NN:[1086..1095] 3-MeO-AAB) (NN:[1097..1107] activation)) (NN:[1108..1117] enzyme-LRB-s-RRB-)) (,:[1117..1118] ,) (NP (DT:[1119..1120] a) (NML (NN:[1121..1131] cytochrome) (NN:[1132..1137] P-450)) (NN:[1138..1148] isozyme-LRB-s-RRB-)) (,:[1148..1149] ,)) (SBAR (WHNP-1 (WDT:[1150..1155] which)) (S (NP-SBJ-1 (-NONE-:[1155..1155] *T*)) (VP (VBZ:[1156..1158] is) (ADJP-PRD (JJ:[1159..1168] different) (,:[1168..1169] ,) (PP (PP (ADVP (IN:[1170..1172] at) (JJS:[1174..1179] least)) (IN:[1180..1182] in) (NP (NN:[1183..1193] proportion))) (CC:[1194..1200] and/or) (PP (IN:[1201..1203] in) (NP (NN:[1204..1210] nature)))) (,:[1210..1211] ,) (PP (IN:[1212..1216] from) (NP (JJ:[1217..1224] hepatic) (NML (NN:[1225..1235] cytochrome) (NN:[1236..1241] P-450)) (NNS:[1242..1250] isozymes)))))))))))) (.:[1250..1251] .))) ;section 8 Span:1255..1298 ;PMID: 3365254 [PubMed - indexed for MEDLINE (SEC (FRAG (NNP:[1255..1259] PMID) (::[1259..1260] :) (CD:[1261..1268] 3365254) (-LRB-:[1269..1270] -LSB-) (NNP:[1270..1276] PubMed) (::[1277..1278] -) (VBN:[1279..1286] indexed) (IN:[1287..1290] for) (NNP:[1291..1298] MEDLINE))) ;ERROR_Orphan Text from EOF Tree File[1298..EOF] ] (ORPH -RSB-)