;PMID: 115774
;source_file_1012.mrg
;Release 0.9 of PennBioIE
;Funded by NSF ITR EIA-0205448

;0)section:[e:0..28] = [t:0..28]
;1)sentence:[e:34..100] = [t:34..100]
;2)section:[e:104..131] = [t:104..131]
;3)sentence:[e:135..288] = [t:135..288]
;4)sentence:[e:290..395] = [t:290..395]
;5)sentence:[e:396..546] = [t:396..546]
;6)sentence:[e:547..735] = [t:547..735]
;7)section:[e:739..782] = [t:739..782]

;section 0 Span:0..28
;Horm Res. 1979;11(4):179-85.
(SEC
  (FRAG (NNP:[0..4] Horm) (NNP:[5..8] Res) (.:[8..9] .)
        ('':[10..18] 1979;11-LRB-) (VBD:[18..20] 4-RRB-) (CD:[20..24] :179)
        (::[24..25] -) (CD:[25..27] 85) (.:[27..28] .)))

;sentence 1 Span:34..100
;Subcellular distribution of aromatase in human placenta and ovary.
;[62..71]:substance:"aromatase"
(SENT
  (NP-HLN
    (NP (JJ:[34..45] Subcellular) (NN:[46..58] distribution))
    (PP (IN:[59..61] of)
      (NP (NN:[62..71] aromatase)))
    (PP-LOC (IN:[72..74] in)
      (NP
        (NP
          (ADJP-1 (JJ:[75..80] human))
          (NN:[81..89] placenta))
        (CC:[90..93] and)
        (NP
          (ADJP-1 (-NONE-:[93..93] *P*))
          (NN:[94..99] ovary))))
    (.:[99..100] .)))

;section 2 Span:104..131
;Thompson EA Jr, Siiteri PK.
(SEC
  (FRAG (NNP:[104..112] Thompson) (NNP:[113..115] EA) (NNP:[116..118] Jr)
        (,:[118..119] ,) (NNP:[120..127] Siiteri) (NNP:[128..131] PK.)))

;sentence 3 Span:135..288
;The aromatization of androstenedione in human ovarian microsomes is inhibited
;by  an antibody to porcine hepatic microsomal NADPH-cytochrome c reductase.
;[156..171]:substance:"androstenedione"
;[220..228]:substance:"antibody"
;[259..287]:substance:"NADPH-cytochrome c reductase"
(SENT
  (S
    (NP-SBJ-1
      (NP (DT:[135..138] The) (NN:[139..152] aromatization))
      (PP (IN:[153..155] of)
        (NP (NN:[156..171] androstenedione)))
      (PP-LOC (IN:[172..174] in)
        (NP (JJ:[175..180] human) (JJ:[181..188] ovarian)
            (NNS:[189..199] microsomes))))
    (VP (VBZ:[200..202] is)
      (VP (VBN:[203..212] inhibited)
        (NP-1 (-NONE-:[212..212] *))
        (PP (IN:[213..215] by)
          (NP-LGS
            (NP (DT:[217..219] an) (NN:[220..228] antibody))
            (PP (TO:[229..231] to)
              (NP (JJ:[232..239] porcine) (JJ:[240..247] hepatic)
                  (JJ:[248..258] microsomal)
                
                (NML (NN:[259..264] NADPH) (HYPH:[264..265] -)
                     (NN:[265..275] cytochrome) (NN:[276..277] c))
                (NN:[278..287] reductase)))))))
    (.:[287..288] .)))

;sentence 4 Span:290..395
;Likewise, the antibody inhibits aromatization in mitochondria isolated from 
;human ovaries and placentae.
;[304..312]:substance:"antibody"
(SENT
  (S
    (ADVP (RB:[290..298] Likewise))
    (,:[298..299] ,)
    (NP-SBJ (DT:[300..303] the) (NN:[304..312] antibody))
    (VP (VBZ:[313..321] inhibits)
      (NP (NN:[322..335] aromatization))
      (PP-LOC (IN:[336..338] in)
        (NP
          (NP (NNS:[339..351] mitochondria))
          (VP (VBN:[352..360] isolated)
            (NP (-NONE-:[360..360] *))
            (PP (IN:[361..365] from)
              (NP
                (NP
                  (ADJP-1 (JJ:[367..372] human))
                  (NNS:[373..380] ovaries))
                (CC:[381..384] and)
                (NP
                  (ADJP-1 (-NONE-:[384..384] *P*))
                  (NNS:[385..394] placentae))))))))
    (.:[394..395] .)))

;sentence 5 Span:396..546
;A given quantity of the antibody produces the same  percent inhibition of
;aromatization in microsomes and mitochondria of both  ovaries and placentae.
;[420..428]:substance:"antibody"
(SENT
  (S
    (NP-SBJ
      (NP (DT:[396..397] A) (JJ:[398..403] given) (NN:[404..412] quantity))
      (PP (IN:[413..415] of)
        (NP (DT:[416..419] the) (NN:[420..428] antibody))))
    (VP (VBZ:[429..437] produces)
      (NP
        (NP (DT:[438..441] the) (JJ:[442..446] same) (NN:[448..455] percent)
            (NN:[456..466] inhibition))
        (PP (IN:[467..469] of)
          (NP (NN:[470..483] aromatization))))
      (PP-LOC (IN:[484..486] in)
        (NP
          (NP (NNS:[487..497] microsomes) (CC:[498..501] and)
              (NNS:[502..514] mitochondria))
          (PP (IN:[515..517] of)
            (NP (CC:[518..522] both) (NNS:[524..531] ovaries)
                (CC:[532..535] and) (NNS:[536..545] placentae))))))
    (.:[545..546] .)))

;sentence 6 Span:547..735
;These data, in addition to the low specific activity  observed for the
;mitochondrial aromatase, indicate that aromatization in  mitochondria
;probably results from microsomal contamination.
;[632..641]:substance:"aromatase"
(SENT
  (S
    (NP-SBJ (DT:[547..552] These) (NNS:[553..557] data))
    (,:[557..558] ,)
    (PP (IN:[559..561] in)
      (NP
        (NP (NN:[562..570] addition))
        (PP (TO:[571..573] to)
          (NP
            (NP (DT:[574..577] the) (JJ:[578..581] low) (JJ:[582..590] specific)
                (NN:[591..599] activity))
            (VP (VBN:[601..609] observed)
              (NP (-NONE-:[609..609] *))
              (PP (IN:[610..613] for)
                (NP (DT:[614..617] the) (JJ:[618..631] mitochondrial)
                    (NN:[632..641] aromatase))))))))
    (,:[641..642] ,)
    (VP (VBP:[643..651] indicate)
      (SBAR (IN:[652..656] that)
        (S
          (NP-SBJ
            (NP (NN:[657..670] aromatization))
            (PP (IN:[671..673] in)
              (NP (NNS:[675..687] mitochondria))))
          (ADVP (RB:[688..696] probably))
          (VP (VBZ:[697..704] results)
            (PP (IN:[705..709] from)
              (NP (JJ:[710..720] microsomal) (NN:[721..734] contamination)))))))
    (.:[734..735] .)))

;section 7 Span:739..782
;PMID: 115774 [PubMed - indexed for MEDLINE]
(SEC
  (FRAG (NNP:[739..743] PMID) (::[743..744] :) (CD:[745..751] 115774)
        (NN:[752..753] -LSB-) (NNP:[753..759] PubMed) (::[760..761] -)
        (NN:[762..769] indexed) (IN:[770..773] for)
        (NNP:[774..782] MEDLINE-RSB-)))