;PMID: 172394 ;source_file_1010.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..42] = [t:0..42] ;1)sentence:[e:48..121] = [t:48..121] ;2)section:[e:125..169] = [t:125..168] ;3)sentence:[e:173..348] = [t:173..348] ;4)sentence:[e:349..410] = [t:349..410] ;5)sentence:[e:411..637] = [t:411..637] ;6)sentence:[e:638..768] = [t:638..768] ;7)sentence:[e:769..860] = [t:769..860] ;8)sentence:[e:862..978] = [t:862..978] ;9)sentence:[e:979..1179] = [t:979..1179] ;10)section:[e:1183..1226] = [t:1183..1225] ;Sentence Matching Errors ;ERROR_Section end mismatch[e:125..169][t:125..168] ;ERROR_Section end mismatch[e:1183..1226][t:1183..1225] ;Token/POS Errors ;ERROR_Token in entity file but not tree[168..169] . ;ERROR_Token in entity file but not tree[1225..1226] ] ;section 0 Span:0..42 ;Mol Cell Endocrinol. 1975 Nov;3(5):375-83. (SEC (FRAG (NNP:[0..3] Mol) (NNP:[4..8] Cell) (NNP:[9..19] Endocrinol) (.:[19..20] .) (CD:[21..25] 1975) (CC:[26..32] Nov;3-LRB-) (CD:[32..33] 5) (-RRB-:[33..34] -RRB-) (CD:[34..38] :375) (::[38..39] -) (CD:[39..41] 83) (.:[41..42] .))) ;sentence 1 Span:48..121 ;Studies on isolated rat adrenal cells metabolism of hydroxylated sterols. ;[113..120]:substance:"sterols" (SENT (NP-HLN (NP (NNS:[48..55] Studies)) (PP (IN:[56..58] on) (NP (NP (NML (VBN:[59..67] isolated) (NN:[68..71] rat) (JJ:[72..79] adrenal) (NNS:[80..85] cells)) (NN:[86..96] metabolism)) (PP (IN:[97..99] of) (NP (VBN:[100..112] hydroxylated) (NNS:[113..120] sterols))))) (.:[120..121] .))) ;section 2 Span:125..168 ;Falke HE, Degenhart HJ, Abeln GJ, Visser HK (SEC (FRAG (NNP:[125..130] Falke) (NNP:[131..133] HE) (,:[133..134] ,) (NNP:[135..144] Degenhart) (NNP:[145..147] HJ) (,:[147..148] ,) (NNP:[149..154] Abeln) (NNP:[155..157] GJ) (,:[157..158] ,) (NNP:[159..165] Visser) (NNP:[166..168] HK))) (ORPH .) ;sentence 3 Span:173..348 ;Corticosterone production by isolated rat adrenal cells in the absence of ;ACTH is stimulated by 20alpha-hydroxycholesterol, 22R-hydroxycholesterol and ; 25-hydroxycholesterol. ;[173..187]:substance:"Corticosterone" ;[247..251]:substance:"ACTH" ;[270..296]:substance:"20alpha-hydroxycholesterol" ;[298..320]:substance:"22R-hydroxycholesterol" ;[326..347]:substance:"25-hydroxycholesterol" (SENT (S (NP-SBJ-1 (NP (NN:[173..187] Corticosterone) (NN:[188..198] production)) (PP (IN:[199..201] by) (NP (VBN:[202..210] isolated) (NN:[211..214] rat) (JJ:[215..222] adrenal) (NNS:[223..228] cells))) (PP (IN:[229..231] in) (NP (NP (DT:[232..235] the) (NN:[236..243] absence)) (PP (IN:[244..246] of) (NP (NN:[247..251] ACTH)))))) (VP (VBZ:[253..255] is) (VP (VBN:[256..266] stimulated) (NP-1 (-NONE-:[266..266] *)) (PP (IN:[267..269] by) (NP-LGS (NN:[270..296] 20alpha-hydroxycholesterol) (,:[296..297] ,) (NN:[298..320] 22R-hydroxycholesterol) (CC:[321..324] and) (NN:[326..347] 25-hydroxycholesterol))))) (.:[347..348] .))) ;ERROR_Orphan Text from Tree File[168..173] . ;sentence 4 Span:349..410 ;This effect is also seen at sub-maximal ACTH concentrations. ;[389..393]:substance:"ACTH" (SENT (S (NP-SBJ-1 (DT:[349..353] This) (NN:[354..360] effect)) (VP (VBZ:[361..363] is) (ADVP (RB:[364..368] also)) (VP (VBN:[369..373] seen) (NP-1 (-NONE-:[373..373] *)) (PP (IN:[374..376] at) (NP (ADJP (AFX:[377..380] sub) (HYPH:[380..381] -) (JJ:[381..388] maximal)) (NN:[389..393] ACTH) (NNS:[395..409] concentrations))))) (.:[409..410] .))) ;sentence 5 Span:411..637 ;Aminoglutethimide (AGI) inhibits the stimulation caused by the three ;hydroxylated cholesterols. In the presence of ACTH, AGI also inhibits ;steroid production both under control conditions and in the presence of the ;sterols. ;[411..428]:substance:"Aminoglutethimide" ;[430..433]:substance:"AGI" ;[494..506]:substance:"cholesterols" ;[527..531]:substance:"ACTH" ;[533..536]:substance:"AGI" ;[552..559]:substance:"steroid" ;[629..636]:substance:"sterols" (SENT (S (NP-SBJ (NP (NN:[411..428] Aminoglutethimide)) (NP (-LRB-:[429..430] -LRB-) (NN:[430..433] AGI) (-RRB-:[433..434] -RRB-))) (VP (VBZ:[435..443] inhibits) (NP (NP (DT:[444..447] the) (NN:[448..459] stimulation)) (VP (VBN:[460..466] caused) (NP (-NONE-:[466..466] *)) (PP (IN:[467..469] by) (NP-LGS (DT:[470..473] the) (CD:[475..480] three) (VBN:[481..493] hydroxylated) (NNS:[494..506] cholesterols)))))) ('':[506..507] .)) (S (PP (IN:[508..510] In) (NP (NP (DT:[511..514] the) (NN:[515..523] presence)) (PP (IN:[524..526] of) (NP (NN:[527..531] ACTH))))) (,:[531..532] ,) (NP-SBJ (NN:[533..536] AGI)) (ADVP (RB:[537..541] also)) (VP (VBZ:[542..550] inhibits) (NP (NN:[552..559] steroid) (NN:[560..570] production)) (PP (CC:[571..575] both) (PP (IN:[576..581] under) (NP (NN:[582..589] control) (NNS:[590..600] conditions))) (CC:[601..604] and) (PP (IN:[605..607] in) (NP (NP (DT:[608..611] the) (NN:[612..620] presence)) (PP (IN:[621..623] of) (NP (DT:[624..627] the) (NNS:[629..636] sterols))))))) (.:[636..637] .))) ;ERROR_Sentence has multiple Children (Sentence Error)[411..637]::S:S: ;sentence 6 Span:638..768 ;The stimulation by 25-hydroxycholesterol is dose-dependent, both in the ;presence and absence of a sub-maximal ACTH concentration. ;[657..678]:substance:"25-hydroxycholesterol" ;[749..753]:substance:"ACTH" (SENT (S (NP-SBJ (NP (DT:[638..641] The) (NN:[642..653] stimulation)) (PP (IN:[654..656] by) (NP (NN:[657..678] 25-hydroxycholesterol)))) (VP (VBZ:[679..681] is) (ADJP-PRD (NN:[682..686] dose) (HYPH:[686..687] -) (JJ:[687..696] dependent)) (,:[696..697] ,) (PP (CC:[698..702] both) (IN:[703..705] in) (NP (NP (DT:[706..709] the) (NN:[711..719] presence) (CC:[720..723] and) (NN:[724..731] absence)) (PP (IN:[732..734] of) (NP (DT:[735..736] a) (ADJP (AFX:[737..740] sub) (HYPH:[740..741] -) (JJ:[741..748] maximal)) (NN:[749..753] ACTH) (NN:[754..767] concentration)))))) (.:[767..768] .))) ;sentence 7 Span:769..860 ;At maximal ACTH concentrations 25-hydroxycholesterol does not give ;additional stimulation. ;[780..784]:substance:"ACTH" ;[801..822]:substance:"25-hydroxycholesterol" (SENT (S (PP (IN:[769..771] At) (NP (JJ:[772..779] maximal) (NN:[780..784] ACTH) (NNS:[786..800] concentrations))) (NP-SBJ (NN:[801..822] 25-hydroxycholesterol)) (VP (VBZ:[823..827] does) (RB:[828..831] not) (VP (VB:[832..836] give) (NP (JJ:[837..847] additional) (NN:[848..859] stimulation)))) (.:[859..860] .))) ;sentence 8 Span:862..978 ;Cycloheximide has no effect on corticosterone production from ;25-hydroxycholesterol whether ACTH is present or not. ;[862..875]:substance:"Cycloheximide" ;[893..907]:substance:"corticosterone" ;[925..946]:substance:"25-hydroxycholesterol" ;[955..959]:substance:"ACTH" (SENT (S (NP-SBJ (NN:[862..875] Cycloheximide)) (VP (VBZ:[876..879] has) (NP (NP (DT:[880..882] no) (NN:[883..889] effect)) (PP (IN:[890..892] on) (NP (NP (NN:[893..907] corticosterone) (NN:[908..918] production)) (PP (IN:[919..923] from) (NP (NN:[925..946] 25-hydroxycholesterol)))))) (SBAR-ADV (IN:[947..954] whether) (S (NP-SBJ (NN:[955..959] ACTH)) (VP (VBZ:[960..962] is) (ADJP-PRD (JJ:[963..970] present)))) (CC:[971..973] or) (RB:[974..977] not))) (.:[977..978] .))) ;sentence 9 Span:979..1179 ;Our results indicate that 25-hydroxycholesterol is a good substrate for the ;study of the cholesterol side-chain cleaving system and the mechanism of ;action of ACTH at the levels of the intact cell. ;[1006..1027]:substance:"25-hydroxycholesterol" ;[1038..1047]:substance:"substrate" ;[1069..1080]:substance:"cholesterol" ;[1140..1144]:substance:"ACTH" (SENT (S (NP-SBJ (PRP$:[979..982] Our) (NNS:[983..990] results)) (VP (VBP:[991..999] indicate) (SBAR (IN:[1000..1004] that) (S (NP-SBJ (NN:[1006..1027] 25-hydroxycholesterol)) (VP (VBZ:[1028..1030] is) (NP-PRD (NP (DT:[1031..1032] a) (JJ:[1033..1037] good) (NN:[1038..1047] substrate)) (PP (IN:[1048..1051] for) (NP (NP (DT:[1052..1055] the) (NN:[1056..1061] study)) (PP (IN:[1062..1064] of) (NP (NP (DT:[1065..1068] the) (NN:[1069..1080] cholesterol) (ADJP (NML (NN:[1082..1086] side) (HYPH:[1086..1087] -) (NN:[1087..1092] chain)) (NN:[1093..1101] cleaving)) (NN:[1102..1108] system)) (CC:[1109..1112] and) (NP (NP (DT:[1113..1116] the) (NN:[1117..1126] mechanism)) (PP (IN:[1127..1129] of) (NP (NP (NN:[1130..1136] action)) (PP (IN:[1137..1139] of) (NP (NN:[1140..1144] ACTH)))))))) (PP (IN:[1145..1147] at) (NP (NP (DT:[1148..1151] the) (NNS:[1152..1158] levels)) (PP (IN:[1159..1161] of) (NP (DT:[1163..1166] the) (JJ:[1167..1173] intact) (NN:[1174..1178] cell)))))))))))) (.:[1178..1179] .))) ;section 10 Span:1183..1225 ;PMID: 172394 [PubMed - indexed for MEDLINE (SEC (FRAG (NNP:[1183..1187] PMID) (::[1187..1188] :) (CD:[1189..1195] 172394) (-LRB-:[1196..1197] -LSB-) (NNP:[1197..1203] PubMed) (::[1204..1205] -) (VBN:[1206..1213] indexed) (IN:[1214..1217] for) (NNP:[1218..1225] MEDLINE))) ;ERROR_Orphan Text from EOF Tree File[1225..EOF] ] (ORPH -RSB-)