;PMID: 4063404 ;source_file_1002.mrg ;Release 0.9 of PennBioIE ;Funded by NSF ITR EIA-0205448 ;0)section:[e:0..36] = [t:0..36] ;1)sentence:[e:42..200] = [t:42..200] ;2)section:[e:204..224] = [t:204..224] ;3)section:[e:228..266] = [t:228..266] ;4)sentence:[e:270..480] = [t:270..480] ;5)sentence:[e:481..617] = [t:481..617] ;6)sentence:[e:618..877] = [t:618..877] ;7)sentence:[e:879..1246] = [t:879..1246] ;8)sentence:[e:1247..1522] = [t:1247..1522] ;9)sentence:[e:1523..1685] = [t:1523..1685] ;10)sentence:[e:1686..1817] = [t:1686..1817] ;11)sentence:[e:1818..2085] = [t:1818..2085] ;12)section:[e:2089..2133] = [t:2089..2133] ;section 0 Span:0..36 ;Biokhimiia. 1985 Nov;50(11):1817-24. (SEC (FRAG (NNP:[0..10] Biokhimiia) (IN:[10..11] .) (CD:[12..16] 1985) (CC:[17..24] Nov;50-LRB-) (CD:[24..26] 11) (-RRB-:[26..27] -RRB-) (CD:[27..32] :1817) (::[32..33] -) (CD:[33..35] 24) (.:[35..36] .))) ;sentence 1 Span:42..200 ;[Induction of cytochrome P-450 forms in liver microsomes of rats in the early ; neonatal period after administration of phenobarbital and ;3-methylcholanthrene] ;[56..72]:cyp450:"cytochrome P-450" ;[161..174]:substance:"phenobarbital" ;[179..199]:substance:"3-methylcholanthrene" (SENT (NP-HLN (-LRB-:[42..43] -LSB-) (NP (NN:[43..52] Induction)) (PP (IN:[53..55] of) (NP (NML (NN:[56..66] cytochrome) (NN:[67..72] P-450)) (NNS:[73..78] forms))) (PP-LOC (IN:[79..81] in) (NP (NP (NN:[82..87] liver) (NNS:[88..98] microsomes)) (PP (IN:[99..101] of) (NP (NP (NNS:[102..106] rats)) (PP (IN:[107..109] in) (NP (DT:[110..113] the) (JJ:[114..119] early) (JJ:[121..129] neonatal) (NN:[130..136] period))))))) (PP-TMP (IN:[137..142] after) (NP (NP (NN:[143..157] administration)) (PP (IN:[158..160] of) (NP (NN:[161..174] phenobarbital) (CC:[175..178] and) (NN:[179..199] 3-methylcholanthrene))))) (-RRB-:[199..200] -RSB-))) ;section 2 Span:204..224 ;[Article in Russian] (SEC (FRAG (NNP:[204..212] -LSB-Article) (IN:[213..215] in) (NNP:[216..223] Russian) (.:[223..224] -RSB-))) ;section 3 Span:228..266 ;Guliaeva LF, Mishin VM, Liakhovich VV. (SEC (FRAG (NNP:[228..236] Guliaeva) (NNP:[237..239] LF) (,:[239..240] ,) (NNP:[241..247] Mishin) (NNP:[248..250] VM) (,:[250..251] ,) (NNP:[252..262] Liakhovich) (NNP:[263..265] VV) (.:[265..266] .))) ;sentence 4 Span:270..480 ;The activity of cytochrome P-450 dependent monooxygenase system from rat ;liver microsomes after induction by phenobarbital and 3-methylcholantrene in ;early neonatal period (3-16 days after birth) was studied. ;[286..326]:substance:"cytochrome P-450 dependent monooxygenase" ;[380..393]:substance:"phenobarbital" ;[398..417]:substance:"3-methylcholantrene" ;[445..449]:quantitative-value:"3-16" ;[450..454]:quantitative-units:"days" (SENT (S (NP-SBJ-1 (NP (DT:[270..273] The) (NN:[274..282] activity)) (PP (IN:[283..285] of) (NP (NP (ADJP (NML (NN:[286..296] cytochrome) (NN:[297..302] P-450)) (JJ:[303..312] dependent)) (NN:[313..326] monooxygenase) (NN:[327..333] system)) (PP (IN:[334..338] from) (NP (NN:[339..342] rat) (NN:[343..348] liver) (NNS:[350..360] microsomes))) (PP-TMP (IN:[361..366] after) (NP (NP (NN:[367..376] induction)) (PP (IN:[377..379] by) (NP (NN:[380..393] phenobarbital) (CC:[394..397] and) (NN:[398..417] 3-methylcholantrene))) (PP (IN:[418..420] in) (NP (JJ:[421..426] early) (JJ:[428..436] neonatal) (NN:[437..443] period) (PRN (-LRB-:[444..445] -LRB-) (NP-TMP (NP (QP (CD:[445..446] 3) (HYPH:[446..447] -) (CD:[447..449] 16)) (NNS:[450..454] days)) (PP (IN:[455..460] after) (NP (NN:[461..466] birth)))) (-RRB-:[466..467] -RRB-))))))))) (VP (VBD:[468..471] was) (VP (VBN:[472..479] studied) (NP-1 (-NONE-:[479..479] *)))) (.:[479..480] .))) ;sentence 5 Span:481..617 ;It was found that the total amount of cytochrome P-450 increases after ;injection of these inducers in neonatal rats of all age groups. ;[520..536]:cyp450:"cytochrome P-450" ;[572..580]:substance:"inducers" (SENT (S (NP-SBJ-2 (NP (PRP:[481..483] It)) (SBAR-1 (-NONE-:[483..483] *EXP*))) (VP (VBD:[484..487] was) (VP (VBN:[488..493] found) (NP-2 (-NONE-:[493..493] *)) (SBAR-1 (IN:[494..498] that) (S (NP-SBJ (NP-SBJ (DT:[499..502] the) (NN:[503..508] total) (NN:[510..516] amount)) (PP (IN:[517..519] of) (NP (NN:[520..530] cytochrome) (NN:[531..536] P-450)))) (VP (VBZ:[537..546] increases) (PP-TMP (IN:[547..552] after) (NP (NP (NN:[553..562] injection)) (PP (IN:[563..565] of) (NP (DT:[566..571] these) (NNS:[572..580] inducers))))) (PP-LOC (IN:[581..583] in) (NP (NP (JJ:[585..593] neonatal) (NNS:[594..598] rats)) (PP (IN:[599..601] of) (NP (DT:[602..605] all) (NN:[606..609] age) (NNS:[610..616] groups)))))))))) (.:[616..617] .))) ;sentence 6 Span:618..877 ;In parallel, in the case of 3-methylcholantrene induction the benz(a)pyrene ;hydroxylase and 7-ethoxyresorufin deethylase activities increase; ;phenobarbital induction causes a rise in the benzphetamine-N-demethylase and ;benz(a)pyrene hydroxylase activities. ;[646..665]:substance:"3-methylcholantrene" ;[681..706]:cyp450:"benz(a)pyrene hydroxylase" ;[711..739]:cyp450:"7-ethoxyresorufin deethylase" ;[762..775]:substance:"phenobarbital" ;[808..835]:cyp450:"benzphetamine-N-demethylase" ;[840..865]:cyp450:"benz(a)pyrene hydroxylase" (SENT (S (S (PP (IN:[618..620] In) (NP (NN:[621..629] parallel))) (,:[629..630] ,) (PP (IN:[631..633] in) (NP (NP (DT:[634..637] the) (NN:[638..642] case)) (PP (IN:[643..645] of) (NP (NN:[646..665] 3-methylcholantrene) (NN:[667..676] induction))))) (NP-SBJ (DT:[677..680] the) (NML (NML (NN:[681..694] benz-LRB-a-RRB-pyrene) (NN:[695..706] hydroxylase) (NML-1 (-NONE-:[706..706] *P*))) (CC:[707..710] and) (NML (NN:[711..728] 7-ethoxyresorufin) (NN:[729..739] deethylase) (NML-1 (NNS:[741..751] activities))))) (VP (VBP:[752..760] increase))) (::[760..761] ;) (S (NP-SBJ (NN:[762..775] phenobarbital) (NN:[776..785] induction)) (VP (VBZ:[786..792] causes) (NP (NP (DT:[793..794] a) (NN:[795..799] rise)) (PP (IN:[800..802] in) (NP (DT:[803..806] the) (NML (NML (NN:[808..835] benzphetamine-N-demethylase) (NML-2 (-NONE-:[835..835] *P*))) (CC:[836..839] and) (NML (NN:[840..853] benz-LRB-a-RRB-pyrene) (NN:[854..865] hydroxylase) (NML-2 (NNS:[866..876] activities))))))))) (.:[876..877] .))) ;sentence 7 Span:879..1246 ;Immunochemical analysis involving the use of antibodies specifically directed ; against cytochrome P-450 of adult rats revealed that the level of cytochrome ; P-450 in the case of 3-methylcholantrene induction increases from 5 to 50%, ;whereas that of cytochrome P-450 upon phenobarbital induction increases from ;5 to 40% in liver microsomes of 3- and 16-day-old rats. ;[924..934]:substance:"antibodies" ;[966..982]:cyp450:"cytochrome P-450" ;[1024..1041]:cyp450:"cytochrome P-450" ;[1057..1076]:substance:"3-methylcholantrene" ;[1102..1110]:quantitative-value:"5 to 50%" ;[1129..1145]:cyp450:"cytochrome P-450" ;[1151..1164]:substance:"phenobarbital" ;[1190..1199]:quantitative-value:"5 to 40%" ;[1223..1224]:quantitative-value:"3" ;[1230..1232]:quantitative-value:"16" ;[1233..1236]:quantitative-units:"day" (SENT (S (NP-SBJ (NP (JJ:[879..893] Immunochemical) (NN:[894..902] analysis)) (VP (VBG:[903..912] involving) (NP (NP (DT:[913..916] the) (NN:[917..920] use)) (PP (IN:[921..923] of) (NP (NP (NNS:[924..934] antibodies)) (VP (ADVP (RB:[935..947] specifically)) (VBN:[948..956] directed) (NP (-NONE-:[956..956] *)) (PP (IN:[958..965] against) (NP (NP (NN:[966..976] cytochrome) (NN:[977..982] P-450)) (PP (IN:[983..985] of) (NP (JJ:[986..991] adult) (NNS:[992..996] rats))))))))))) (VP (VBD:[997..1005] revealed) (SBAR (IN:[1006..1010] that) (S (NP-SBJ (NP (DT:[1011..1014] the) (NN:[1015..1020] level)) (PP (IN:[1021..1023] of) (NP (NN:[1024..1034] cytochrome) (NN:[1036..1041] P-450))) (PP (IN:[1042..1044] in) (NP (NP (DT:[1045..1048] the) (NN:[1049..1053] case)) (PP (IN:[1054..1056] of) (NP (NN:[1057..1076] 3-methylcholantrene) (NN:[1077..1086] induction)))))) (VP (VBZ:[1087..1096] increases) (NP-EXT (QP (IN:[1097..1101] from) (CD:[1102..1103] 5) (TO:[1104..1106] to) (CD:[1107..1109] 50)) (NN:[1109..1110] %)) (,:[1110..1111] ,) (SBAR-ADV (IN:[1113..1120] whereas) (S (NP-SBJ (NP (DT:[1121..1125] that)) (PP (IN:[1126..1128] of) (NP (NP (NN:[1129..1139] cytochrome) (NN:[1140..1145] P-450)) (PP-TMP (IN:[1146..1150] upon) (NP (NN:[1151..1164] phenobarbital) (NN:[1165..1174] induction)))))) (VP (VBZ:[1175..1184] increases) (NP-EXT (QP (IN:[1185..1189] from) (CD:[1190..1191] 5) (TO:[1193..1195] to) (CD:[1196..1198] 40)) (NN:[1198..1199] %)) (PP-LOC (IN:[1200..1202] in) (NP (NP (NN:[1203..1208] liver) (NNS:[1209..1219] microsomes)) (PP (IN:[1220..1222] of) (NP (NP (ADJP (NML (CD:[1223..1224] 3) (HYPH:[1224..1225] -) (NML-3 (-NONE-:[1225..1225] *P*))) (ADJP-1 (-NONE-:[1225..1225] *P*))) (NML-2 (-NONE-:[1225..1225] *P*))) (CC:[1226..1229] and) (NP (ADJP (NML (CD:[1230..1232] 16) (HYPH:[1232..1233] -) (NML-3 (NN:[1233..1236] day))) (ADJP-1 (HYPH:[1236..1237] -) (JJ:[1237..1240] old))) (NML-2 (NNS:[1241..1245] rats)))))))))))))) (.:[1245..1246] .))) ;sentence 8 Span:1247..1522 ;The mode of inhibition of various substrates metabolism by antibodies in ;neonatal rat microsomes suggests that the 3-methylcholantrene-induced ;cytochrome P-448, like in adult rats, participates in the hydroxylation of ;benz(a)pyrene and O-deethylation of 7-etoxyresorufin. ;[1282..1292]:substance:"substrates" ;[1307..1317]:substance:"antibodies" ;[1364..1383]:substance:"3-methylcholantrene" ;[1392..1408]:cyp450:"cytochrome P-448" ;[1468..1481]:substance:"benz(a)pyrene" ;[1505..1521]:substance:"7-etoxyresorufin" (SENT (S (NP-SBJ (NP (DT:[1247..1250] The) (NN:[1251..1255] mode)) (PP (IN:[1256..1258] of) (NP (NP (NN:[1259..1269] inhibition)) (PP (IN:[1270..1272] of) (NP (JJ:[1274..1281] various) (NNS:[1282..1292] substrates) (NN:[1293..1303] metabolism))) (PP (IN:[1304..1306] by) (NP (NNS:[1307..1317] antibodies))) (PP-LOC (IN:[1318..1320] in) (NP (JJ:[1321..1329] neonatal) (NN:[1330..1333] rat) (NNS:[1334..1344] microsomes)))))) (VP (VBZ:[1345..1353] suggests) (SBAR (IN:[1355..1359] that) (S (NP-SBJ (DT:[1360..1363] the) (ADJP (NN:[1364..1383] 3-methylcholantrene) (HYPH:[1383..1384] -) (VBN:[1384..1391] induced)) (NN:[1392..1402] cytochrome) (NN:[1403..1408] P-448)) (,:[1408..1409] ,) (S-ADV (NP-SBJ (-NONE-:[1409..1409] *)) (ADJP-PRD (IN:[1410..1414] like) (PP-LOC (IN:[1415..1417] in) (NP (JJ:[1418..1423] adult) (NNS:[1424..1428] rats))))) (,:[1428..1429] ,) (VP (VBZ:[1431..1443] participates) (PP (IN:[1444..1446] in) (NP (DT:[1447..1450] the) (NML (NML (NML (NN:[1451..1464] hydroxylation)) (PP (IN:[1465..1467] of) (NP (NN:[1468..1481] benz-LRB-a-RRB-pyrene)))) (CC:[1482..1485] and) (NML (NML (NN:[1486..1500] O-deethylation)) (PP (IN:[1501..1503] of) (NP (NN:[1505..1521] 7-etoxyresorufin))))))))))) (.:[1521..1522] .))) ;sentence 9 Span:1523..1685 ;The participation of phenobarbital-induced cytochrome P-450 in the ;metabolism of benzphetamine and aldrin in neonatal rats is much lower than ;in the adult ones. ;[1544..1557]:substance:"phenobarbital" ;[1566..1582]:cyp450:"cytochrome P-450" ;[1605..1618]:substance:"benzphetamine" ;[1623..1629]:substance:"aldrin" (SENT (S (NP-SBJ (NP (DT:[1523..1526] The) (NN:[1527..1540] participation)) (PP (IN:[1541..1543] of) (NP (ADJP (NN:[1544..1557] phenobarbital) (HYPH:[1557..1558] -) (VBN:[1558..1565] induced)) (NN:[1566..1576] cytochrome) (NN:[1577..1582] P-450))) (PP (IN:[1583..1585] in) (NP (NP (DT:[1587..1590] the) (NN:[1591..1601] metabolism)) (PP (IN:[1602..1604] of) (NP (NN:[1605..1618] benzphetamine) (CC:[1619..1622] and) (NN:[1623..1629] aldrin))) (PP-LOC (IN:[1630..1632] in) (NP (JJ:[1633..1641] neonatal) (NNS:[1642..1646] rats)))))) (VP (VBZ:[1647..1649] is) (ADJP-PRD (ADJP (RB:[1650..1654] much) (JJR:[1655..1660] lower)) (PP (IN:[1661..1665] than) (PP-LOC (IN:[1667..1669] in) (NP (DT:[1670..1673] the) (JJ:[1674..1679] adult) (NNS:[1680..1684] ones)))))) (.:[1684..1685] .))) ;sentence 10 Span:1686..1817 ;The metabolism of benz(a)pyrene in phenobarbital-induced neonatal rat ;microsomes in all age groups is not inhibited by antibodies. ;[1704..1717]:substance:"benz(a)pyrene" ;[1721..1734]:substance:"phenobarbital" ;[1806..1816]:substance:"antibodies" (SENT (S (NP-SBJ-1 (NP (DT:[1686..1689] The) (NN:[1690..1700] metabolism)) (PP (IN:[1701..1703] of) (NP (NN:[1704..1717] benz-LRB-a-RRB-pyrene))) (PP-LOC (IN:[1718..1720] in) (NP (NP (ADJP (NN:[1721..1734] phenobarbital) (HYPH:[1734..1735] -) (VBN:[1735..1742] induced)) (JJ:[1744..1752] neonatal) (NN:[1753..1756] rat) (NNS:[1757..1767] microsomes)) (PP (IN:[1768..1770] in) (NP (DT:[1771..1774] all) (NN:[1775..1778] age) (NNS:[1779..1785] groups)))))) (VP (VBP:[1786..1788] is) (RB:[1789..1792] not) (VP (VBN:[1793..1802] inhibited) (NP-1 (-NONE-:[1802..1802] *)) (PP (IN:[1803..1805] by) (NP-LGS (NNS:[1806..1816] antibodies))))) (.:[1816..1817] .))) ;sentence 11 Span:1818..2085 ;The age-dependent differences in inhibition of metabolism and the increase ;in the benz(a)pyrene hydroxylase activity in phenobarbital-induced rats ;suggest that the spectrum of inducible forms of cytochrome P-450 in neonatal ;rats differ from that in adult animals. ;[1902..1927]:cyp450:"benz(a)pyrene hydroxylase" ;[1940..1953]:substance:"phenobarbital" ;[2016..2032]:cyp450:"cytochrome P-450" (SENT (S (NP-SBJ (NP (NP (DT:[1818..1821] The) (ADJP (NN:[1823..1826] age) (HYPH:[1826..1827] -) (JJ:[1827..1836] dependent)) (NNS:[1837..1848] differences)) (PP (IN:[1849..1851] in) (NP (NP (NN:[1852..1862] inhibition)) (PP (IN:[1863..1865] of) (NP (NN:[1866..1876] metabolism)))))) (CC:[1877..1880] and) (NP (NP (DT:[1881..1884] the) (NN:[1885..1893] increase)) (PP (IN:[1894..1896] in) (NP (DT:[1897..1900] the) (NML (NN:[1902..1915] benz-LRB-a-RRB-pyrene) (NN:[1916..1927] hydroxylase)) (NN:[1928..1936] activity))) (PP-LOC (IN:[1937..1939] in) (NP (ADJP (NN:[1940..1953] phenobarbital) (HYPH:[1953..1954] -) (VBN:[1954..1961] induced)) (NNS:[1962..1966] rats))))) (VP (VBP:[1967..1974] suggest) (SBAR (IN:[1975..1979] that) (S (NP-SBJ (NP (DT:[1981..1984] the) (NN:[1985..1993] spectrum)) (PP (IN:[1994..1996] of) (NP (NP (JJ:[1997..2006] inducible) (NNS:[2007..2012] forms)) (PP (IN:[2013..2015] of) (NP (NN:[2016..2026] cytochrome) (NN:[2027..2032] P-450))))) (PP-LOC (IN:[2033..2035] in) (NP (JJ:[2036..2044] neonatal) (NNS:[2045..2049] rats)))) (VP (VBP:[2050..2056] differ) (PP (IN:[2057..2061] from) (NP (NP (DT:[2063..2067] that)) (PP-LOC (IN:[2068..2070] in) (NP (JJ:[2071..2076] adult) (NNS:[2077..2084] animals))))))))) (.:[2084..2085] .))) ;section 12 Span:2089..2133 ;PMID: 4063404 [PubMed - indexed for MEDLINE] (SEC (FRAG (NNP:[2089..2093] PMID) (::[2093..2094] :) (CD:[2095..2102] 4063404) (NN:[2103..2104] -LSB-) (NNP:[2104..2110] PubMed) (::[2111..2112] -) (NN:[2113..2120] indexed) (IN:[2121..2124] for) (NNP:[2125..2133] MEDLINE-RSB-)))