Arch Biochem Biophys. 1985 Apr;238(1):187-94.  

Cumene hydroperoxide effected hydroperoxidation by cytochrome P-450.

Chen C, Gurka DP.

9-Methylfluorene was found to be oxygenated to 9-hydroperoxy-9-methylfluorene
and 9-hydroxy-9-methylfluorene by cytochrome P-450 in the presence of cumene
hydroperoxide. Molecular oxygen is required and carbon monoxide is inhibitory.
The reaction is inhibited by SKF-525A and metyrapone. Metyrapone and cumene
hydroperoxide also retard the conversion of 9-hydroperoxy-9-methylfluorene to
9-hydroxy-9-methylfluorene. The reaction is different from
hydroperoxide-supported oxygenation, since the cumene hydroperoxide appears to
act as an effector of the enzyme rather than oxygen donor. It is suggested that
substrates with stable radicals can be dioxygenated in this manner.

PMID: 3985615 [PubMed - indexed for MEDLINE]