Cancer Lett. 1987 Dec;38(1-2):107-17.  

Effect of nicotinamide on hepatic microsomal drug metabolising system in
tumour-bearing rats and mice.

Kamat JP, Narurkar LM, Narurkar MV.

Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay, India.

Administration of nicotinamide to Wistar rats (100 mg/kg body wt.) bearing
Yoshida sarcoma (ascites) tumour as well as to Swiss and CBA mice (250 mg/kg
body wt.) bearing the transplantable fibrosarcoma and the spontaneously induced
mammary carcinoma, respectively, was shown to bring about a reversal of the
decreased activity of NADPH-cytochrome c reductase in host livers of the
tumour-bearing animals. Nicotinamide injection was also shown to bring about a
significant increase in the levels of host hepatic cytochromes P-450 and b5 and
in the activities of aminopyrine demethylase and UDP-glucuronosyl transferase
which were shown to be low in the tumour-bearing rats. Treatment with
nicotinamide was shown to be equally effective in reversing the inhibited
activities of hepatic drug metabolising enzymes observed in healthy adult rats
injected with serum from the tumour-bearing rats. Administration of nicotinamide
to adult male rats brought about an increased incorporation of [14C]leucine in
hepatic microsomal proteins which was insensitive to inhibition by actinomycin D
at a dose of 1 mg/kg body wt. but could be inhibited by the antibiotic at a
lower dose of 0.1 mg/kg body wt. as well as by cycloheximide.

PMID: 2961435 [PubMed - indexed for MEDLINE]