Enzyme. 1984;31(3):129-36.  

Response of the rat's hepatic drug-metabolizing enzyme system to chemotherapy of
Trypanosoma b. brucei infections with Berenil and Suramin.

Emerole GO, Thabrew MI.

Berenil (4,4-diamidinodiazoaminobenzene-diacetamide acetate) or Suramin [sodium
salt of 8-(3-benzamido-4-methylbenzamido)-naphthalene-1,3,5-trisulfonic acid]
treatment of rats infected with Trypanosoma b. brucei enhanced hepatic
microsomal aniline hydroxylase and p-aminopyrine N-demethylase activities. While
Suramin inhibited significantly the activities of cytoplasmic glutamate
dehydrogenase and lactate dehydrogenase, Berenil had no effect. The kinetic
profiles of these enzymes consistently showed a Km value similar to that of
controls. Both cytosolic and microsomal glutathione-S transferase and microsomal
epoxide hydratase were unaffected by Suramin. However, a significant increase in
cytosolic glutathione-S transferase was observed with Berenil. Microsomal
phospholipids were not affected by any of the drugs.

PMID: 6734575 [PubMed - indexed for MEDLINE]