Agents Actions. 1981 Dec;11(6-7):736-40.  

Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole
(6-SAI).

Muller D, Hirschelmann R.

Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was
inhibited after a single dosage or seven administration of 6-SAI to old rats.
These effects were independent of the development of arthritis. Changes in
cytochrome P-450 concentration after 6-SAI treatment were insignificant and thus
not responsible for the decrease in drug metabolism. In vitro 6-SAI inhibited
ethylmorphine N-demethylation; the inhibition was of a mixed type. 6-SAI bound
to cytochrome P-450 and induced a type II spectrum. The magnitude of
hexobarbital-induced type I spectral changes was diminished by 6-SAI. It is
concluded that 6-SAI inhibits cytochrome P-450-dependent drug metabolism by
binding to cytochrome P-450.

PMID: 7340465 [PubMed - indexed for MEDLINE]