Acta Biochim Pol. 1984;31(4):409-19.  

A study on the Prethcamide hydroxylation system in rat hepatic microsomes.

Szumilo T, Bryla P, Byra A.

Ethyl butamide and propyl butamide, the active constituents of the analeptic
drug named Prethcamide (Ciba-Geigy), undergo biotransformation to respective
single metabolites in the presence of rat hepatic microsomes and the
NADPH-generating system. Spectral analysis showed that the metabolites were
hydroxylated forms of the drug. The hydroxylation was stimulated by NADH and
increased ionic strength, and inhibited by the known cytochrome P-450
inhibitors, e.g. SKF-525A, metyrapone, CO and KCN. The drug formed type I
binding spectrum with cytochrome P-450.

PMID: 6543484 [PubMed - indexed for MEDLINE]